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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2011

Open Access 01-04-2011 | Gastrointestinal Oncology

Comparison of the 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer: Results of a Chinese Single-Institution Study of 1,503 Patients

Authors: Wei Wang, Xiao-wei Sun, Chao-feng Li, Lin Lv, Yuan-fang Li, Ying-bo Chen, Da-zhi Xu, MD, Rajiv Kesari, Chun-yu Huang, Wei Li, You-qing Zhan, MD, Zhi-wei Zhou, MD

Published in: Annals of Surgical Oncology | Issue 4/2011

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Abstract

Aim

To evaluate the prognostic efficacy of the 7th edition tumor–node–metastasis (TNM) classification compared with the 6th edition in gastric cancer patients.

Methods

A total of 1,503 gastric cancer patients undergoing surgical resection were staged using the 6th and 7th edition staging systems. Homogeneity, discriminatory ability, and monotonicity of gradients of the two systems were compared using linear trend χ2, likelihood ratio χ2 statistics, and Akaike information criterion (AIC) calculations.

Results

Significant differences in 5-year survival rates were observed for the T, N, and M subgroups using the 7th edition system, except for stage N2 and N3 patients in the 6th edition system. There were no significant differences in survival between IB and IIA in the 7th edition system. Patients with stage IV disease due to T4/N3 in the 6th edition system who were downstaged to stage III in the 7th edition system had significantly better survival than those who remained at stage IV. The 7th edition system had higher linear trend and likelihood ratio χ2 scores, and smaller AIC values compared with those for the 6th edition, which represented the optimum prognostic stratification.

Conclusions

Our study suggests that the 7th edition system performs better than the 6th edition in several aspects.
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Metadata
Title
Comparison of the 6th and 7th Editions of the UICC TNM Staging System for Gastric Cancer: Results of a Chinese Single-Institution Study of 1,503 Patients
Authors
Wei Wang
Xiao-wei Sun
Chao-feng Li
Lin Lv
Yuan-fang Li
Ying-bo Chen
Da-zhi Xu, MD
Rajiv Kesari
Chun-yu Huang
Wei Li
You-qing Zhan, MD
Zhi-wei Zhou, MD
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 4/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1424-2

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