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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2010

01-07-2010 | Hepatobiliary Tumors

Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection

Authors: Seong Yeon Cho, MD, Sang-Jae Park, MD, PhD, Seong Hoon Kim, MD, Sung-Sik Han, MD, Young-Kyu Kim, MD, Kwang-Woong Lee, MD, Soon-Ae Lee, MD, Eun Kyung Hong, MD, Woo Jin Lee, MD, Sang Myung Woo, MD

Published in: Annals of Surgical Oncology | Issue 7/2010

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Abstract

Background

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, but the studies for the outcome after resection of ICC are rare. The aim of this study was to elucidate outcomes and prognostic factors of ICC in patients undergoing hepatic resection.

Methods

A retrospective study was conducted with a total of 63 patients who underwent surgical resection with curative intent for ICC. We performed the survival analysis with preoperative and postoperative clinicopathologic factors according to the clinical outcome.

Results

The cumulative 1-, 3-, and 5-year survival rates were 68.2, 50.5, and 31.8%, respectively. Univariate analysis revealed that patient’s old age, high preoperative carbohydrate antigen 19-9 (CA19-9) level, major vessel invasion, T classification, lymph node metastasis, lymphatic invasion, perineural invasion, intrahepatic metastasis, and narrow resection margin were statistically significant. By multivariate analysis, patient’s old age, high preoperative CA19-9 level, lymphatic invasion, and narrow resection margin were independent dismal prognostic factors. The preoperative CA19-9 level shows a significant correlation with some histopathologic factors including major vessel invasion, bile duct invasion, and perineural invasion.

Conclusions

Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome. An adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC.
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Metadata
Title
Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection
Authors
Seong Yeon Cho, MD
Sang-Jae Park, MD, PhD
Seong Hoon Kim, MD
Sung-Sik Han, MD
Young-Kyu Kim, MD
Kwang-Woong Lee, MD
Soon-Ae Lee, MD
Eun Kyung Hong, MD
Woo Jin Lee, MD
Sang Myung Woo, MD
Publication date
01-07-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 7/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-0938-y

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