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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2010

01-03-2010 | Breast Oncology

Obesity and Angiolymphatic Invasion in Primary Breast Cancer

Authors: Erin F. Gillespie, Melony E. Sorbero, PhD, MS, MPH, David A. Hanauer, MD, MS, Michael S. Sabel, MD, Emily J. Herrmann, Laura J. Weiser, Christina H. Jagielski, MPH, Jennifer J. Griggs, MD, MPH

Published in: Annals of Surgical Oncology | Issue 3/2010

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Abstract

Background

Obesity is associated with poorer breast cancer-specific survival. The purpose of this study was to investigate the relationships between obesity and the presence of angiolymphatic invasion as well as other features of invasive breast cancer, including stage at presentation, estrogen receptor (ER) status, triple-negative phenotype, and tumor grade.

Methods

Detailed clinical and pathologic data were abstracted from the medical records of all 1,312 patients with stage I–III primary breast cancer who had breast surgery at the University of Michigan Comprehensive Cancer Center between January 1, 2000 and December 31, 2006. Bivariate and multivariate analyses were conducted to investigate the relationships between body mass index and tumor biologic features, controlling for menopausal status, diabetes and hypertension, hormone replacement therapy before diagnosis, race, and ethnicity.

Results

In multivariate analyses, severe obesity was independently associated with the presence of angiolymphatic invasion [odds ratio (OR) 1.80, 95% confidence interval (CI) 1.08–2.99, joint test of significance, P = 0.03]. Severe obesity was associated with lower likelihood of triple-negative breast cancer (OR 0.39, 95% CI 0.16–0.96). Among premenopausal women with diabetes, ER-negative (OR 5.22, 95% CI 1.12–24.29) and triple-negative (OR 14.8, 95% CI 1.92–113.91) disease was significantly more common.

Discussion

In this large sample of invasive breast cancers, obesity was independently associated with the presence of angiolymphatic invasion. Higher rates of angiolymphatic invasion among obese women may account in part for poorer outcomes among obese women with breast cancer.
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Metadata
Title
Obesity and Angiolymphatic Invasion in Primary Breast Cancer
Authors
Erin F. Gillespie
Melony E. Sorbero, PhD, MS, MPH
David A. Hanauer, MD, MS
Michael S. Sabel, MD
Emily J. Herrmann
Laura J. Weiser
Christina H. Jagielski, MPH
Jennifer J. Griggs, MD, MPH
Publication date
01-03-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 3/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0797-6

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