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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2010

Open Access 01-01-2010 | Melanomas

Survival and the Sentinel Lymph Node in Melanoma

Author: Mark Faries, MD

Published in: Annals of Surgical Oncology | Issue 1/2010

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Excerpt

Lymphatic mapping with sentinel lymphadenectomy (SLND) has become the standard approach to intermediate thickness melanoma at most melanoma centers worldwide. The procedure has yielded numerous, unquestioned benefits for patients with melanoma, including providing vital prognostic information and improving disease-free survival with reduction of morbid regional nodal recurrences. However, some uncertainty regarding the impact of the procedure on overall survival persists.1,2 …
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Morton DL, Thompson JF, Cochran AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006;355:1307–17.CrossRefPubMed
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Morton D, Hoon D, Cochran A, et al. Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastases. Ann Surg. 2003;238:538–49.PubMed
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van Akkooi AC, Nowecki ZI, Voit C, et al. Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes. Ann Surg. 2008;248:949–55.CrossRefPubMed
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Kretschmer L, Hilgers R. Research supports the view that sentinel node biopsy is the standard of care in high-risk primary melanoma. J Clin Oncol. 2006;24:2965–6 (author reply 2966–7).CrossRefPubMed
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Jakub JW, Huebner M, Shivers S, et al. The number of lymph nodes involved with metastatic disease does not affect outcome in melanoma patients as long as all disease is confined to the sentinel lymph node. Ann Surg Oncol. 2009;16:2245–51.CrossRefPubMed
Metadata
Title
Survival and the Sentinel Lymph Node in Melanoma
Author
Mark Faries, MD
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 1/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0782-0

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