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Published in: Annals of Surgical Oncology 7/2008

01-07-2008 | Healthcare Policy and Outcomes

Survival After Resection of Ampullary Carcinoma: A National Population-Based Study

Authors: Jessica B. O’Connell, MD, Melinda A. Maggard, MD, Jesse Manunga Jr., MD, James S. Tomlinson, MD, Howard A. Reber, MD, Clifford Y. Ko, MD, O. Joe Hines, MD

Published in: Annals of Surgical Oncology | Issue 7/2008

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Abstract

Background

Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer. However, most reports have been conducted at single institutions with small sample sizes, and results may not reflect the practices and outcomes in the community. Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.

Methods

Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988–2003) were collected. Primary outcome was survival (5-year), and secondary outcome was stage at presentation. Comparisons were made with outcomes reported in the literature (resection rate, perioperative mortality, and 5-year survival).

Results

Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection. Thirty-seven percent presented with stage I tumors. Perioperative mortality (30 day) was 7.6% after resection, and 5-year survival was 36.8%. Few patients died if they survived at least 5 years. The cancer registry data showed less early stage disease, higher perioperative mortality, and lower 5-year survival compared with published reports.

Conclusions

This is the largest population-based analysis of ampullary carcinoma. Resection rates and survival at the national level are lower, in general, compared with cancer center reports, which may have implications for regionalizing these procedures. Many patients surviving at least 5 years seem to be cured by surgical resection.
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Metadata
Title
Survival After Resection of Ampullary Carcinoma: A National Population-Based Study
Authors
Jessica B. O’Connell, MD
Melinda A. Maggard, MD
Jesse Manunga Jr., MD
James S. Tomlinson, MD
Howard A. Reber, MD
Clifford Y. Ko, MD
O. Joe Hines, MD
Publication date
01-07-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 7/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-008-9886-1

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