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01-05-2008 | Gastrointestinal Oncology

Clinical Significance of BMP7 in Human Colorectal Cancer

Authors: Kazuo Motoyama, MD, Fumiaki Tanaka, MD, PhD, Yoshimasa Kosaka, MD, Koshi Mimori, MD, PhD, Hiroyuki Uetake, MD, PhD, Hiroshi Inoue, MD, PhD, Kenichi Sugihara, MD, PhD, Masaki Mori, MD, PhD, FACS

Published in: Annals of Surgical Oncology | Issue 5/2008

Abstract

Background

Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor (TGF)-β superfamily. Recent studies demonstrated that the expression patterns of BMPs are altered in several tumors. The purpose of the current study was to examine the expression of BMP7 in malignant and normal colorectal tissues, and to analyze whether BMP7 expression levels correlate with clinicopathological variables and prognosis in colorectal cancer.

Methods

Paired colorectal tissue samples from cancer and corresponding nonmalignant tissues were obtained from 65 patients who underwent surgical resection for colorectal cancer. The expression status of BMP7 mRNA was investigated by quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR) and protein expression was analyzed by an immunohistochemical study.

Results

Quantitative real-time RT-PCR showed that BMP7 mRNA expression in cancerous tissue was significantly higher than that in normal tissue (p < 0.0001). An immunohistochemical study revealed that BMP7 was predominantly expressed in cancer cells. Elevated BMP7 expression was significantly correlated with depth of tumor invasion, liver metastasis, liver recurrence, advanced Dukes’ classification, and cancer-related death (p < 0.05, 0.001, 0.01, 0.05 and 0.01, respectively). Furthermore, patients with the highest levels of BMP7 expression showed the poorest prognosis (p < 0.01). A multivariate analysis showed that BMP7 expression status was an independent prognostic factor of overall survival (relative risk, 2.29; 95% confidence interval, 1.08–5.30; p < 0.05).

Conclusions

Expression of BMP7 in colorectal tumors correlates with parameters of pathological aggressiveness such as liver metastasis and poor prognosis. Thus, BMP7 could be a useful clinical marker for colorectal cancer patients.

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Title: Clinical Significance of BMP7 in Human Colorectal Cancer
Authors: Kazuo Motoyama, MD
Fumiaki Tanaka, MD, PhD
Yoshimasa Kosaka, MD
Koshi Mimori, MD, PhD
Hiroyuki Uetake, MD, PhD
Hiroshi Inoue, MD, PhD
Kenichi Sugihara, MD, PhD
Masaki Mori, MD, PhD, FACS
Publication date: 01-05-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 5/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-007-9746-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical Significance of BMP7 in Human Colorectal Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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