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Open Access 01-02-2008 | Thoracic Oncology

Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)

Authors: Eiji Ogawa, MD, Kazumasa Takenaka, MD, PhD, Hiromichi Katakura, MD, PhD, Masashi Adachi, MD, Yosuke Otake, MD, PhD, Yoshinobu Toda, PhD, Hirokazu Kotani, MD, PhD, Toshiaki Manabe, MD, PhD, Hiromi Wada, MD, PhD, Fumihiro Tanaka, MD, PhD

Published in: Annals of Surgical Oncology | Issue 2/2008

Abstract

Purpose

Aurora-A, also known as STK15/BTAK, is a member of the protein serine/threonine kinase family, and experimental studies have revealed that Aurora-A plays critical roles in cell mitosis and in carcinogenesis. However, no clinical studies on Aurora-A expression in non-small-cell lung cancer (NSCLC) have been reported. Thus, the present study was conducted to assess the clinical significance of Aurora-A status.

Experimental Design

A total of 189 consecutive patients with resected pathologic (p-)stage I-IIIA, NSCLC were retrospectively reviewed, and immunohistochemical staining was used to detect Aurora-A expression.

Results

Aurora-A expression was negative in 31 patients (16.4%); among Aurora-A positive patients, 124 patients showed pure diffuse cytoplasmic Aurora-A expression and the other 34 patients showed perimembrane Aurora-A expression. Perimembrane Aurora-A tumors showed the highest proliferative index (PI) (mean PIs for negative, diffuse cytoplasmic, and perimembrane tumors: 49.2, 41.7, and 63.5, respectively; P < .001). Five-year survival rates of Aurora-A negative, diffuse cytoplasmic, and perimembrane patients were 67.8%, 66.7%, and 47.6%, respectively, showing the poorest postoperative survival in perimembrane patients (P = .033). Subset analyses revealed that perimembrane Aurora-A expression was a significant factor to predict a poor prognosis in squamous cell carcinoma patients, not in adenocarcinoma patients. A multivariate analysis confirmed that perimembrane Aurora-A expression was an independent and significant factor to predict a poor prognosis.

Conclusions

Perimembrane Aurora-A status was a significant factor to predict a poor prognosis in correlation with enhanced proliferative activity in NSCLC.

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Title: Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)
Authors: Eiji Ogawa, MD
Kazumasa Takenaka, MD, PhD
Hiromichi Katakura, MD, PhD
Masashi Adachi, MD
Yosuke Otake, MD, PhD
Yoshinobu Toda, PhD
Hirokazu Kotani, MD, PhD
Toshiaki Manabe, MD, PhD
Hiromi Wada, MD, PhD
Fumihiro Tanaka, MD, PhD
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 2/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-007-9653-8

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Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)

Abstract

Purpose

Experimental Design

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Experimental Design

Results

Conclusions

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