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01-02-2008 | Gastrointestinal Oncology

The Expression of Type IV Collagen α6 Chain Is Related to the Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Authors: Yoshifumi Baba, Ken-ichi Iyama, MD, PhD, Koei Ikeda, Shinji Ishikawa, Naoko Hayashi, Nobutomo Miyanari, Yoshikazu Sado, Yoshifumi Ninomiya, Hideo Baba

Published in: Annals of Surgical Oncology | Issue 2/2008

Abstract

Background

The destruction of the basement membrane (BM) is the first step in cancer cell invasion and metastasis. Type IV collagen is a major component of the BM, and is composed of six genetically distinct α(IV) chains: α1(IV) to α6(IV). The loss of α5/α6(IV) chains from the epithelial BM at the early stage of cancer cell invasion has been reported in several cancers. However, the expression of α5/α6(IV) chains in esophageal squamous cell carcinoma (ESCC) remains unclear.

Methods

The expression of α(IV) chains in 116 resected ESCC specimens was immunohistochemically examined. The role of α6(IV) chain was assessed in ESCC cell lines by short interfering RNA (siRNA).

Results

In intraepithelial carcinoma, the α5/α6(IV) chains were stained in a continuous linear pattern in the BM. In some cases of ESCC with the invasion beyond the lamina propria, the α5/α6(IV) chains were lost in the BM zone surrounding the cancer cell nests, but in other cases they remained. In the former, the disease-free survival and overall survival were significantly better than in those with the latter. The down-regulation of α6(IV) chain expression by siRNA revealed a slight increase of cancer cell invasiveness.

Conclusions

The evaluation of α5/α6(IV) chains may be a useful marker for determining tumor cell properties, as a prognostic factor, in patients with ESCC.

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Title: The Expression of Type IV Collagen α6 Chain Is Related to the Prognosis in Patients with Esophageal Squamous Cell Carcinoma
Authors: Yoshifumi Baba
Ken-ichi Iyama, MD, PhD
Koei Ikeda
Shinji Ishikawa
Naoko Hayashi
Nobutomo Miyanari
Yoshikazu Sado
Yoshifumi Ninomiya
Hideo Baba
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 2/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-007-9592-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The Expression of Type IV Collagen α6 Chain Is Related to the Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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