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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2007

01-09-2007 | Endocrine Tumors

Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer

Authors: Funda Kosova, Bahadır Çetin, Melih Akıncı, Sabahattin Aslan, Zeki Arı, Aylin Sepici, Nilgün Altan, Abdullah Çetin

Published in: Annals of Surgical Oncology | Issue 9/2007

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Abstract

Aims and Background

The oxidation of protein plays an essential role in the pathogenesis of an important number of degenerative and cancer diseases, which is now widely recognized. The aim is to examine advanced oxidation protein products (AOPPs), lipid peroxidation products malondialdehyde (MDA), and ferrous oxidation in xylenol orange (FOX) in blood samples of papillary thyroid cancer patients compared with healthy controls to determine the oxidation status and the change after thyroidectomy.

Methods

Thirty-five female thyroid cancer patients who underwent total thyroidectomy and 39 female control subjects were included into this study. Prethyroidectomy and postthyroidectomy, AOPP, FOX, and MDA levels were studied.

Results

Prethyroidectomy AOPP, FOX, and MDA levels were significantly higher compared to control (P < .05). In postthyroidectomy AOPP, FOX, and MDA levels were significantly decreased compared with prethyroidectomy levels (P < .05). However, postthyroidectomy levels on the 20th day were still significantly higher, compared to control subjects (P < .05).

Conclusion

In conclusion, all of AOPP, FOX, and MDA levels that are markers of protein oxidation and lipid hyperoxidation may induce thyroid cancer development and begin to decrease after thyroidectomy.
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Metadata
Title
Advanced Oxidation Protein Products, Ferrous Oxidation in Xylenol Orange, and Malondialdehyde Levels in Thyroid Cancer
Authors
Funda Kosova
Bahadır Çetin
Melih Akıncı
Sabahattin Aslan
Zeki Arı
Aylin Sepici
Nilgün Altan
Abdullah Çetin
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 9/2007
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9425-5

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