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Annals of Surgical Oncology

Published in:

01-02-2007

A Population-Based Study on the Management and Outcome in Patients with Locally Recurrent Rectal Cancer

Authors: G. Palmer, MD, A. Martling, MD, PhD, B. Cedermark, MD, PhD, T. Holm, MD, PhD

Published in: Annals of Surgical Oncology | Issue 2/2007

Abstract

Background

Although outcome in patients with rectal cancer has improved with preoperative radiotherapy and total mesorectal excision, local recurrence still remains a problem. The condition is difficult to cure and little is known on whether the prognosis for patients with locally recurrent tumours has changed over time. Few population-based studies have been performed.

Method

Two thousand three hundred and eighteen patients in Stockholm, Sweden had a potentially curative resection for rectal cancer between 1995 and 2003. Until 2005, 141 (6%) developed a local recurrence. Management and outcome for these patients were studied and compared to a previously analysed cohort of 156 patients with local recurrence, treated 1980–1991.

Results

Of the 141 patients, 57 (40%) had surgery with a curative intent, 48 (34%) radio- and/or chemotherapy and 36 (26%) symptomatic palliation only. The total 5-year survival was 9%. Twenty-five patients had a potentially curative resection, with a 5-year survival of 57%. The corresponding figures for the 156 patients in the earlier cohort were 4 and 42%.

Conclusion

Although outcome for patients with local recurrence of rectal cancer is dismal, the prognosis has improved slightly over time. A radical resection is a prerequisite for cure and the proportion having a potentially curative resection has increased. Multidisciplinary management, including optimised preoperative staging and patient selection for surgery, radical surgical approach and more effective adjuvant treatments are necessary to further improve the prognosis.

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Title: A Population-Based Study on the Management and Outcome in Patients with Locally Recurrent Rectal Cancer
Authors: G. Palmer, MD
A. Martling, MD, PhD
B. Cedermark, MD, PhD
T. Holm, MD, PhD
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 2/2007
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-006-9256-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A Population-Based Study on the Management and Outcome in Patients with Locally Recurrent Rectal Cancer

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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