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Published in:

01-09-2006

Sentinel Node Biopsy Using Dye and Isotope Double Tracers in Early Gastric Cancer

Authors: Jun Ho Lee, MD, Keun Won Ryu, MD, Chan Gyoo Kim, MD, Seok-Ki Kim, MD, Jong-Seok Lee, MD, Myeong-Cherl Kook, MD, Il Ju Choi, MD, Young Woo Kim, MD, Hee Jin Chang, MD, Jae-Moon Bae, MD

Published in: Annals of Surgical Oncology | Issue 9/2006

Abstract

Background

The results of sentinel node (SN) biopsy have been improved by the use of dye and isotope double tracers in melanoma and breast cancer. However, the usefulness of this double tracer technique has not been determined in gastric cancer. The aim of this study was to investigate the possibility of improving SN biopsy results by using double tracers in gastric cancer.

Methods

Sixty-four gastric adenocarcinoma patients preoperatively diagnosed as cT1N0, were enrolled in the study. ^99mTc tin colloid was injected by preoperative endoscopy, and lymphoscintigraphy was performed prior to operation. After laparotomy, isosulfan blue was intraoperatively injected using an endoscope. Blue-stained or radioactive nodes were identified and defined as SNs. Gastrectomy with D2 lymphadenectomy was performed in all patients. All dissected lymph nodes were evaluated for metastasis by hematoxylin and eosin staining and immunohistochemistry.

Results

SN detection rates using dye, isotope, or both tracers were 95.3%, 84.4%, and 96.9%, respectively, and their corresponding sensitivities were 52.9%, 52.9%, and 70.6%. In the pT1 subset, the sensitivity of the double tracer was 87.5%; and in a subset of tumors with diameter <4.5 cm, this was also 87.5%.

Conclusions

These findings confirm that SN biopsy results are improved by using double tracers in gastric cancer and suggest that SN biopsy is suitable in cases of small-sized early gastric cancer.

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Title: Sentinel Node Biopsy Using Dye and Isotope Double Tracers in Early Gastric Cancer
Authors: Jun Ho Lee, MD
Keun Won Ryu, MD
Chan Gyoo Kim, MD
Seok-Ki Kim, MD
Jong-Seok Lee, MD
Myeong-Cherl Kook, MD
Il Ju Choi, MD
Young Woo Kim, MD
Hee Jin Chang, MD
Jae-Moon Bae, MD
Publication date: 01-09-2006
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 9/2006
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-006-9038-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sentinel Node Biopsy Using Dye and Isotope Double Tracers in Early Gastric Cancer

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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