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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2006

01-02-2006

Outcomes of Mass Screening for Gastric Carcinoma

Authors: Chikara Kunisaki, MD, Junko Ishino, MD, Susumu Nakajima, MD, Hisahiko Motohashi, MD, Hirotoshi Akiyama, MD, Masato Nomura, MD, Goro Matsuda, MD, Yuichi Otsuka, MD, Hidetaka Andrew Ono, MD, Hiroshi Shimada, MD

Published in: Annals of Surgical Oncology | Issue 2/2006

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Abstract

Background

Therapeutic results of gastric cancer have been improved by early detection of gastric cancer with the mass screening system in Japan. The objective of our study was to assess the efficacy of mass screening for gastric cancer by using a barium meal.

Methods

A series of 1050 patients (364 in the screened group and 686 in the nonscreened group) were included in this study from April 1992 to March 2000. Patient characteristics, therapeutic results, and prognostic factors were compared in the two groups.

Results

The screened patients tended to be younger and male, with tumors in the middle third of the stomach that were of a macroscopically superficial type, with a smaller diameter, and at an earlier stage. They had fewer metastatic lymph nodes and underwent more frequent curative resection. Among the screened patients with curatively resected disease, tumors tended to be of a smaller diameter, and there were fewer metastatic lymph nodes in both early and advanced cases. Disease-specific survival was significantly better in the screened cases among all registered and curatively resected patients. Mass screening achieved significantly better surgical results in early or advanced gastric cancer patients who received curative resection. Multivariate analysis revealed that mass screening was an independent prognostic factor (hazard ratio, .3949; P < .0001), together with depth of invasion, lymph node metastasis, age, and tumor diameter.

Conclusions

Mass screening by using barium meal examination for gastric cancer detects cancer at an early stage and produces good therapeutic results.
Literature
1.
Tominaga S, Aoki K, Fujimoto I, Kurihara M. Cancer mortality and morbidity statistics. Japan and the world—1994. Gann Monogr Cancer Res 1994;41:175–7
2.
Kong SH, Park do J, Lee HJ, et al. Clinicopathologic features of asymptomatic gastric adenocarcinoma patients in Korea. Jpn J Clin Oncol 2004;34:1–7CrossRefPubMed
3.
Fukao A, Tsubono Y, Tsuji I, Hisamichi S, Sugahara N, Takano A. The evaluation of screening for gastric cancer in Miyagi prefecture, Japan. A population-based case-control study. Int J Cancer 1995;60:45–8PubMed
4.
Matsukuma A, Furusawa M, Tomoda H, Seo Y. A clinicopathological study of asymptomatic gastric cancer. Br J Cancer 1996;74:1647–50PubMed
5.
Mori Y, Arita T, Shimoda K, Yasuda K, Yoshida T, Kitano S. Effect of periodic endoscopy for gastric cancer on early detection and improvement of survival. Gastric Cancer 2001;4:132–6PubMed
6.
Arai J, Yamada H, Maruyama M. Initial radiographic findings of early gastric cancer detected in health check programs and human “dry dock” (multiphasic screening) collective health checks and treated by endoscopic mucosal resection. Gastric Cancer 2002;5:35–42CrossRefPubMed
7.
Kondo H, Gotoda T, Ono H, et al. Percutaneous traction-assisted EMR by using an insulation-tipped electrosurgical knife for early-stage gastric cancer. Gastrointest Endosc 2004;59:284–8CrossRefPubMed
8.
Kitano S, Shiraishi N. Current status of laparoscopic gastrectomy for cancer in Japan. Surg Endosc 2004;18:182–5. CrossRefPubMed
9.
Kitano S, Shiraishi N, Kakisako K, Yasuda K, Inomata M, Adachi Y. Laparoscopy-assisted Billroth-I gastrectomy (LADG) for cancer: our 10 years’ experience. Surg Laparosc Endosc Percutan Tech 2002;12:204–7CrossRefPubMed
10.
Ohshima A, Hirata N, Ubukata T, Umeda K, Fujimoto I. Evaluation of a mass screening program for stomach cancer with a case-control study design. Int J Cancer 1986;38:829–33
11.
McCulloch P, Brown P, Martin B, Williams E. The effects of an awareness-raising program for patients and primary care physicians on the early detection of gastro-oesophageal cancer. Surgery 2003;133:154–61CrossRefPubMed
12.
Sobin LH, Wittekind CH. TNM: Classification of Malignant Tumours. 6th ed. New York: Wiley-Liss, 2002
13.
Hagiwara A, Sawai K, Sakakura C, et al. Complete omentectomy and extensive lymphadenectomy with gastrectomy improves the survival of gastric cancer patients with metastases in the adjacent peritoneum. Hepatogastroenterology 1998;45:1922–9PubMed
14.
Liorens P. Gastric cancer mass survey in Chile. Semin Surg Oncol 1991;7:339–43
15.
Pisani P, Oliver WE, Parkin DM, Alvarez N, Vivas J. Case-control study of gastric cancer screening in Venezuela. Br J Cancer 1994;69:1102–5PubMed
16.
Kunisaki C, Shimada H, Nomura M, et al. Surgical outcome of serosa-negative advanced gastric cancer. Anticancer Res 2004;24:3169–76PubMed
17.
Kunisaki C, Shimada H, Takahashi M, et al. Implication of extended lymph node dissection stratified for advanced gastric cancer. Anticancer Res 2003;23:4181–6PubMed
18.
Mizoue T, Yoshimura T, Tokui N, et al. Japan Collaborative Cohort Study Group. Prospective study of screening for stomach cancer in Japan. Int J Cancer 2003;106:103–7CrossRefPubMed
19.
Kubota H, Kotoh T, Masunaga R, et al. Impact of screening survey of gastric cancer on clinicopathological features and survival: retrospective study at a single institution. Surgery 2000;128:41–7PubMed
Metadata
Title
Outcomes of Mass Screening for Gastric Carcinoma
Authors
Chikara Kunisaki, MD
Junko Ishino, MD
Susumu Nakajima, MD
Hisahiko Motohashi, MD
Hirotoshi Akiyama, MD
Masato Nomura, MD
Goro Matsuda, MD
Yuichi Otsuka, MD
Hidetaka Andrew Ono, MD
Hiroshi Shimada, MD
Publication date
01-02-2006
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 2/2006
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/ASO.2006.04.028

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