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01-03-2006 | Original Article

Profile of Plasma Angiogenic Factors Before and After Hepatectomy for Colorectal Cancer Liver Metastases

Authors: Sam S. Yoon, MD, Sung H. Kim, MD, PhD, Mithat Gonen, PhD, Nancy M. Heffernan, RN, BSN, Kara Y. Detwiller, BS, William R. Jarnagin, MD, Michael D’Angelica, MD, Leslie H. Blumgart, MD, Kenneth K. Tanabe, MD, Ronald P. DeMatteo, MD

Published in: Annals of Surgical Oncology | Issue 3/2006

Abstract

Background

Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy.

Methods

We analyzed blood samples from 26 patients with colorectal cancer liver metastases before and after liver resection and used samples from 20 healthy controls as a reference. Plasma levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and hepatocyte growth factor (HGF) were measured, and levels were correlated with recurrence.

Results

The median preoperative levels of all four factors were significantly higher and more variable in colorectal cancer liver metastasis patients than in controls. HGF and bFGF levels increased significantly 3 days and 1 month after hepatectomy, respectively, and returned to near preoperative levels at 3 months. Postoperative VEGF and EGF levels remained relatively stably increased over 3 months. After a median follow-up of 19 months, 10 patients (42%) experienced recurrence. Higher preoperative VEGF and HGF levels correlated with subsequent recurrence (P = .018 and .021, respectively), and a preoperative adjusted total value of all four factors accurately identified patients at low, moderate, and high risk of recurrence (P = .034). Patients who experienced disease recurrence also had relatively higher bFGF levels 3 months after operation (P = .035).

Conclusions

Plasma angiogenic factors are increased in patients with colorectal cancer liver metastases and remain increased at least 3 months after partial hepatectomy. Measurement of certain factors before and after hepatic resection can predict recurrence. Targeted biological agents may counteract the tumor-promoting effects of these circulating factors on subclinical disease.

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Title: Profile of Plasma Angiogenic Factors Before and After Hepatectomy for Colorectal Cancer Liver Metastases
Authors: Sam S. Yoon, MD
Sung H. Kim, MD, PhD
Mithat Gonen, PhD
Nancy M. Heffernan, RN, BSN
Kara Y. Detwiller, BS
William R. Jarnagin, MD
Michael D’Angelica, MD
Leslie H. Blumgart, MD
Kenneth K. Tanabe, MD
Ronald P. DeMatteo, MD
Publication date: 01-03-2006
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2006
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2006.03.060

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Profile of Plasma Angiogenic Factors Before and After Hepatectomy for Colorectal Cancer Liver Metastases

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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