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01-01-2006 | Original Article

Prognostic Effect of Re-Excision in Adult Soft Tissue Sarcoma of the Extremity

Authors: Marco Fiore, MD, Paolo G. Casali, MD, Rosalba Miceli, PhD, Luigi Mariani, MD, Rossella Bertulli, MD, Laura Lozza, MD, Paola Collini, MD, Patrizia Olmi, MD, Chiara Mussi, MD, Alessandro Gronchi, MD

Published in: Annals of Surgical Oncology | Issue 1/2006

Abstract

Background

We explored the outcome of patients with primary adult soft tissue sarcoma (STS) of the extremities undergoing re-excision after previous unplanned surgery.

Methods

A total of 597 consecutive adult patients with primary extremity STS were treated with conservative surgery at our institution over a 20-year time span. A total of 318 patients were referred after unplanned excisions, and the remaining 279 underwent primary resection at our center. The two groups significantly differed in tumor size and depth. The assessed end points were sarcoma-specific mortality, local recurrence, and distant metastasis. Univariable and multivariable analyses, adjusted for other prognostic factors, were performed in the competing risks framework.

Results

The adjusted 10-year cumulative incidences in re-excised and primarily operated patients were, respectively, 18.7% and 16.4% (P = .535) for local relapse, 17.6% and 20.2% (P = .541) for metastasis, and 20.4% and 22.4% (P = .645) for mortality. Among patients who underwent re-excision, evidence of microscopic residual disease on pathologic examination had a significant prognostic effect on multivariable analysis for distant metastases (P = .002). A trend for survival was detected as well.

Conclusions

At a referral center with a liberal policy of re-excisions in adult primary STS of the extremities, the outcome of patients who underwent re-excision was similar to that of patients who had primary resections. Evidence of microscopic residual disease at re-excision was a marker of clinical aggressiveness.

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Title: Prognostic Effect of Re-Excision in Adult Soft Tissue Sarcoma of the Extremity
Authors: Marco Fiore, MD
Paolo G. Casali, MD
Rosalba Miceli, PhD
Luigi Mariani, MD
Rossella Bertulli, MD
Laura Lozza, MD
Paola Collini, MD
Patrizia Olmi, MD
Chiara Mussi, MD
Alessandro Gronchi, MD
Publication date: 01-01-2006
Publisher: Springer New York
Published in: Annals of Surgical Oncology / Issue 1/2006
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2006.03.030

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic Effect of Re-Excision in Adult Soft Tissue Sarcoma of the Extremity

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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