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01-05-2005

Is Hepatic Resection for Large or Multinodular Hepatocellular Carcinoma Justified? Results From a Multi-Institutional Database

Authors: Kelvin K. Ng, PhD, Jean-Nicolas Vauthey, MD, Timothy M. Pawlik, MD, Gregory Y. Lauwers, MD, Jean-Marc Regimbeau, MD, Jacques Belghiti, MD, Iwao Ikai, MD, Yoshio Yamaoka, MD, Steven A. Curley, MD, David M. Nagorney, MD, Irene O. Ng, MD, Sheung Tat Fan, MD, Ronnie T. Poon, MS

Published in: Annals of Surgical Oncology | Issue 5/2005

Abstract

Background

The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database.

Methods

The perioperative and long-term outcomes of 404 patients with small HCC (<5 cm in diameter; group 1) were compared with those of 380 patients with large or multinodular HCC (group 2). The prognostic factors in the latter group were analyzed.

Results

The postoperative complication rate (27% vs. 23%; P = .16) and hospital mortality rate (2.4% vs. 2.7%; P = .82) were similar between groups. The overall survival rates were significantly higher in group 1 than group 2 (1 year, 88% vs. 74%; 3 years, 76% vs. 50%; 5 years, 58% vs. 39%; P < .001). Among patients in group 2, five independent prognostic factors were identified to be associated with a worse overall survival: namely, symptomatic disease, presence of cirrhosis, multinodular tumor, microvascular tumor invasion, and positive histological margin.

Conclusions

Hepatic resection can be safely performed in patients with large or multinodular HCC, with an overall 5-year survival rate of 39%. Symptomatic disease, the presence of cirrhosis, a multinodular tumor, microvascular invasion, and a positive histological margin are independently associated with a less favorable survival outcome.

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Title: Is Hepatic Resection for Large or Multinodular Hepatocellular Carcinoma Justified? Results From a Multi-Institutional Database
Authors: Kelvin K. Ng, PhD
Jean-Nicolas Vauthey, MD
Timothy M. Pawlik, MD
Gregory Y. Lauwers, MD
Jean-Marc Regimbeau, MD
Jacques Belghiti, MD
Iwao Ikai, MD
Yoshio Yamaoka, MD
Steven A. Curley, MD
David M. Nagorney, MD
Irene O. Ng, MD
Sheung Tat Fan, MD
Ronnie T. Poon, MS
Publication date: 01-05-2005
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 5/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/ASO.2005.06.004

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is Hepatic Resection for Large or Multinodular Hepatocellular Carcinoma Justified? Results From a Multi-Institutional Database

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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