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Neurological Research and Practice

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Open Access 01-12-2022 | Torticollis Spasticus | Research article

Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study

Authors: Clemens Jacksch, Kirsten E. Zeuner, Ann-Kristin Helmers, Karsten Witt, Günther Deuschl, Steffen Paschen

Published in: Neurological Research and Practice | Issue 1/2022

Abstract

Background

Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the longitudinal ten years treatment efficacy of DBS in the globus pallidus internus (GPI).

Methods

A retrospective single-center data analysis was performed on patients with idiopathic CD, who were treated with GPI DBS for at least 10 years. TWSTR severity score and individual sub-items were compared between pre and post DBS surgery (n = 15) over time.

Results

There was a significant and persistent positive effect regarding the severity of TWSTRS between the conditions immediately before and 1, 5, and 10 years after establishment of GPI DBS (mean difference: 6.6–7 ± 1.6). Patients with increasing CD complexity showed a poorer response to established treatment forms, such as injection of botulinum toxin and were thus DBS candidates. Especially a predominant torticollis was significantly improved by DBS.

Conclusion

GPI DBS is an effective procedure especially in severely affected patients with a positive 10-year outcome. It should be considered in more complex CD-forms or predominant torticollis.

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Title: Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study
Authors: Clemens Jacksch
Kirsten E. Zeuner
Ann-Kristin Helmers
Karsten Witt
Günther Deuschl
Steffen Paschen
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Torticollis Spasticus
Tremor
Deep Brain Stimulation
Botulinum Toxin
Published in: Neurological Research and Practice / Issue 1/2022
Electronic ISSN: 2524-3489
DOI: https://doi.org/10.1186/s42466-022-00214-8

At a glance: The STEP trials

Springer Medicine

Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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