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01-12-2022 | Stroke | Review

Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis

Authors: Ei Zune The, Ne Naing Lin, Ching Jocelyn Chan, Jason Cher Wei Loon, Benjamin Yong-Qiang Tan, Chee Seong Raymond Seet, Hock Luen Teoh, Joy Vijayan, Leong Litt Leonard Yeo

Published in: Neurological Research and Practice | Issue 1/2022

Abstract

Background

Extracranial artery dissection involving either internal carotid artery or vertebral artery is a major cause of stroke in adults under 50 years of age. There is no conclusive evidence whether antiplatelets or anticoagulants are better suited in the treatment of extracranial artery dissection.

Objectives

To determine whether antiplatelets or anticoagulants have advantage over the other in the treatment of extracranial artery dissection for secondary prevention of recurrent ischemic events or death.

Methods

Present meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement. Database search was done in Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception to May 2021 using pre-defined search strategy. Additional studies were identified from reference lists from included studies, reviews and previous meta-analyses. Outcome measures were ischaemic stroke, ischaemic stroke or transient ischaemic attack (TIA), and death.

Results

Two RCTs and 64 observational studies were included in the meta-analysis. While the outcome measures of stroke, stroke or TIA and death were numerically higher with antiplatelet use, there were no statistically significant differences between antiplatelets and anticoagulants.

Conclusion

We found no significant difference between antiplatelet and anticoagulation treatment after extracranial artery dissection. The choice of treatment should be tailored to individual cases.

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Title: Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis
Authors: Ei Zune The
Ne Naing Lin
Ching Jocelyn Chan
Jason Cher Wei Loon
Benjamin Yong-Qiang Tan
Chee Seong Raymond Seet
Hock Luen Teoh
Joy Vijayan
Leong Litt Leonard Yeo
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Stroke
Anticoagulant
Vertebral Artery Dissection
Vertebral Artery Dissection
Published in: Neurological Research and Practice / Issue 1/2022
Electronic ISSN: 2524-3489
DOI: https://doi.org/10.1186/s42466-022-00188-7

ACC 2024 Congress

Springer Medicine

Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis

Abstract

Background

Objectives

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusion

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