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Maxillofacial Plastic and Reconstructive Surgery
Published in: Maxillofacial Plastic and Reconstructive Surgery 1/2019

Open Access 01-12-2019 | Botulinum Toxin | Research

Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats

Authors: Janghoon Ahn, Seong-Gon Kim, Min-Keun Kim, Insan Jang, Hyun Seok

Published in: Maxillofacial Plastic and Reconstructive Surgery | Issue 1/2019

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Abstract

Background

The purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat.

Methods

Ten Sprague Dawley rats were used in this study. When the rats were 13 days old, 0.5 units of BTX was injected into the anterior belly of the digastric muscle for the experimental group (n = 5). For the control, the same volume of normal saline was injected (n = 5). The rats were sacrificed at 60 days old, and the skulls were harvested for micro-computed tomography (μCT) analysis.

Results

In anthropometric analysis, the zygomatic arch and mandibular bi-condylar width were significantly lower in the experimental group than those in the control group (P = 0.025 and 0.027, respectively). The maxillary point width was significantly higher in the experimental group than that in the control group (P = 0.020).

Conclusion

BTX injection into the anterior belly of the digastric muscle had effects on the maxillofacial bony width in growing rats.
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Metadata
Title
Botulinum toxin A injection into the anterior belly of the digastric muscle increased the posterior width of the maxillary arch in developing rats
Authors
Janghoon Ahn
Seong-Gon Kim
Min-Keun Kim
Insan Jang
Hyun Seok
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Keyword
Botulinum Toxin
Published in
Maxillofacial Plastic and Reconstructive Surgery / Issue 1/2019
Electronic ISSN: 2288-8586
DOI
https://doi.org/10.1186/s40902-019-0203-7

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