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Clinical Phytoscience

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Open Access 01-12-2022 | Rifampicin | Original contribution

Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity

Authors: Temidayo Ogunmoyole, Onaopemiposi Olufunke Falusi, Funmilayo Oderinde

Published in: Clinical Phytoscience | Issue 1/2022

Abstract

Background

Curative potential of Sida acuta Burm. f. (Malvaceae) leaves on hepatotoxicity and nephrotoxicity induced by carbon tetrachloride (CCl₄) and rifampicin was studied. This was aimed at providing a potent therapeutic alternative to conventional drugs in the management of liver and kidney diseases.

Methodology

Carbon tetrachloride (3 ml/kg bw) and rifampicn (250 mg/kg bw) were administered to induce liver and kidney damage in selected groups of albino rats. Graded doses of Sida acuta leaves extract as well as silymarin (200 mg/kg bw) were then post-administered to experimental animals placed into eight groups of five animals each. Biomarkers of oxidative stress such as lipid profile, alanine aminotransferase (ALT), aspartate aminotransferase (ALT), alkaline phosphatase (ALP), superoxide dismutase (SOD), catalase (CAT), urea, uric acid, bilirubin and malonidialdehyde (MDA) were determined. Histopathological observations of both renal and hepatic tissues of experimental animals were also performed.

Results

Animals exposed to CCl₄ and rifampicin without treatment exhibited significant derangement in lipid profile, elevated levels of ALT, ALT, ALP, urea, uric acid, bilirubin and MDA in the serum and tissues homogenates. Superoxide dismutase and catalase activities were significantly inhibited while level of GSH was depleted. Following treatment with S. acuta extract, all deranged parameters including histological alterations were restored in a dose-dependent manner comparable to animals treated with silymarin.

Conclusion

Biochemical and histopathological data obtained from the present study confirmed that Sida acuta is a potential antioxidant plant that can be exploited in the management of liver and kidney dysfunctions.

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Title: Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity
Authors: Temidayo Ogunmoyole
Onaopemiposi Olufunke Falusi
Funmilayo Oderinde
Publication date: 01-12-2022
Publisher: Springer Berlin Heidelberg
Keyword: Rifampicin
Published in: Clinical Phytoscience / Issue 1/2022
Electronic ISSN: 2199-1197
DOI: https://doi.org/10.1186/s40816-021-00336-7

At a glance: The STEP trials

Springer Medicine

Sida acuta leaf extract attenuates oxidants-induced animal model of nephrotoxicity and hepatotoxicity

Abstract

Background

Methodology

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methodology

Results

Conclusion

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