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Clinical Phytoscience
Published in: Clinical Phytoscience 1/2019

Open Access 01-12-2019 | Antidepressant Drugs | Original contribution

Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum

Authors: Md Rashidur Rahman, Mostakim Sharif, Mohammad Ali, Sheikh Shahriar Rajib

Published in: Clinical Phytoscience | Issue 1/2019

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Abstract

Background

The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity.

Results

The result showed robust and dose-dependent antidepressant-like activity. There are statistically significant (p* < 0.05) reductions in the duration of immobility time both in forced swimming and tail suspension test. In open field test, measurement of locomotion, defecation and rearing are evaluated. There is statistically significant (p* < 0.05) increase in locomotion, rearing and defecation of mice compared to control group.

Conclusions

These results clearly demonstrates that methanolic extract of the seeds of Sesamum indicum has potential antidepressant activity and further studies should be conducted to identify, isolate and evaluate its potential active compound responsible for such effect.
Literature
1.
Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study. Lancet. 2010;382:1575–86.CrossRef
2.
Pedersen CB, Mors O, Bertelsen A, Waltoft BL, Agerbo E, McGrath JJ, et al. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry. 2014;71:573–81.CrossRef
3.
Kessler RC, Birnbaum H, Bromet E, Hwang I, Sampson N, Shahly V. Age differences in major depression: results from the National Comorbidity Survey Replication (NCS-R). Psychol Med. 2010;40:225–37.CrossRef
4.
Eaton WW, Shao H, Nestadt G, Lee BH, Bienvenu OJ, Zandi P. Population-based study of first onset and chronicity in major depressive disorder. Arch Gen Psychiatry. 2008;65:513–20.CrossRef
5.
Monroe SM, Harkness KL. Recurrence in major depression: a conceptual analysis. Psychol Rev. 2011;118:655–74.CrossRef
6.
Yiend J, Paykel E, Merritt R, Lester K, Doll H, Burns T. Long term outcome of primary care depression. J Affec Disord. 2009;118:79–6.CrossRef
7.
Ustun TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJ. Global burden of depressive disorders in the year 2000. British J of Psychiatry. 2004;184:386–92.CrossRef
8.
Zhang ZJ. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci. 2004;75:1659–99.CrossRef
9.
Kumar P, Yadav V, Chaurasia V, Rao VC. Pharmacological investigation of anticonvulsant activity of Sesamum indicum Linn. 50% ethanol leaves extract. Research J Pharm and Tech. 2011;4:1822–4.
10.
Vishwanath HS, Anilakumar KR, Harsha SN, Khanum F, Bawa AS. In vitro antioxidant activity of Sesamum indicum seeds. Asian J Pharm Clin Res. 2012;5:56–60.
11.
Xu H, Wen YP, Zhao W, He Q. In Vitro antitumour activity of Sesamum indicum Linn flower extracts. Tropical J of Pharmaceutical Res. 2010; 455–62.
12.
Jamarkattel-Pandit N, Pandit NR, Kim MY, Park SH, Kim KS, Choi H, Kim H, Bu Y. Neuroprotective effect of defatted sesame seeds extract against in vitro and in vivo ischemic neuronal damage. Planta Med. 2010;76:20–6.CrossRef
13.
Seukep JA, Fankam AG, Djeussi DE, Voukeng IK, Tankeo SB, Noumdem JA, et al. Antibacterial activities of the methanol extracts of seven Cameroonian dietary plants against bacteria expressing MDR phenotypes. Springerplus. 2013;2:363.CrossRef
14.
Bhuvaneswari P, Krishnakumari S. Antihyperglycemic potential of Sesamum indicum (Linn) seeds in Streptozotocin induced diabetic rats. Int J of Pharm Pharm Sci. 2012;4:527–31.
15.
Gilani AU, Aftab K. Presence of acetylcholine-like substance(s) in Sesamum indicum. Arch Pharm Res. 1992;15:95–8.CrossRef
16.
Kiran K, Asad M. Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J of Experimental Biol. 2008;46:777–82.
17.
Yuan H, Chung S, Ma Q, Ye L, Piao G. Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue. Exp Ther Med. 2016:338–44.
18.
Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacol. 1985;85:367–70.CrossRef
19.
Porsolt RD, Bertin A, Jalfre M. Behavioural despair in mice: a primary screening test for antidepressants. Acrh Inter Pharmacodyn Ther. 1977;229:327–36.
20.
Carlini EA, Contar JD, Silva-Filho AR, Da Silveira-Filho NG, Frochtengarten ML, Bueno OF. Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J Ethnopharmacol. 1986;17:37–64.CrossRef
Metadata
Title
Evaluation of the antidepressant-like activity of the methanolic extract of the seeds of Sesamum indicum
Authors
Md Rashidur Rahman
Mostakim Sharif
Mohammad Ali
Sheikh Shahriar Rajib
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Phytoscience / Issue 1/2019
Electronic ISSN: 2199-1197
DOI
https://doi.org/10.1186/s40816-018-0098-3

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