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International Journal of Implant Dentistry

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Open Access 01-12-2021 | Research

Effects of low-dose aspirin on the osseointegration process in rats

Authors: Ana Carolina Lupepsa, Paula Vargas-Sanchez, Marcella Goetz Moro, Leomar Emanuel Almeida Mecca, Marcela Claudino, Priscilla Barbosa Ferreira Soares, Amanda Regina Fischborn, Jéssica Daniela Andreis, Gilson Cesar Nobre Franco

Published in: International Journal of Implant Dentistry | Issue 1/2021

Abstract

Background

Several drugs are capable of promoting changes in bone metabolism. The aim of this study was to evaluate the effect of long-term low-dose aspirin (LDA) therapy on implant osseointegration.

Methods

Male Wistar rats were divided into 4 groups (n = 8/group) according to oral gavage solution received prior (42 days) to the implant surgery on the tibia. The control group was treated with saline solution for 7 (CG-7) and 28 (CG-28) days. The use of low-dose aspirin was performed in AG groups (6.75 mg/kg of aspirin) for 7 (AG-7) and 28 (AG-28) days. After experimental periods, histomorphometric evaluation of bone-to-implant contact (BIC) and the bone area between threads (BABT) was performed.

Results

Reduced BIC values were detected in AG-7 (62.8% ± 17.1) group compared to AG-28 (91.9% ± 5.4), CG-7 (82.7% ± 15.2), and CG-28 (89.9% ± 9.7). BABT evaluation revealed lower values in AG-7 (70.9% ± 15.2) compared to AG-28 (95.4% ± 3.7) and CG-28 (87.1% ± 10.2) groups.

Conclusions

The treatment with low doses of aspirin promoted a discrete inhibitory effect in the early stages (7 days) of repair after implant placement, specifically in the bone deposition. However, these effects were not detected in the late stages (28 days), considering BIC and BABT parameters.

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Title: Effects of low-dose aspirin on the osseointegration process in rats
Authors: Ana Carolina Lupepsa
Paula Vargas-Sanchez
Marcella Goetz Moro
Leomar Emanuel Almeida Mecca
Marcela Claudino
Priscilla Barbosa Ferreira Soares
Amanda Regina Fischborn
Jéssica Daniela Andreis
Gilson Cesar Nobre Franco
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Implant Dentistry / Issue 1/2021
Electronic ISSN: 2198-4034
DOI: https://doi.org/10.1186/s40729-020-00283-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Effects of low-dose aspirin on the osseointegration process in rats

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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