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Open Access 01-12-2014 | Research

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

Authors: Michail Koutrolos, Kerstin Berer, Naoto Kawakami, Hartmut Wekerle, Gurumoorthy Krishnamoorthy

Published in: Acta Neuropathologica Communications | Issue 1/2014

Abstract

Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effects in the peripheral immune organs, their role within the central nervous system (CNS) during experimental autoimmune encephalomyelitis is unclear. Here, by combining a selectively timed regulatory T cells depletion with 2-photon microscopy, we report that regulatory T cells exercise their dynamic control over effector T cells in the CNS. Acute depletion of regulatory T cells exacerbated experimental autoimmune encephalomyelitis severity which was accompanied by increased pro-inflammatory cytokine production and proliferation of effector T cells. Intravital microscopy revealed that, in the absence of regulatory T cells, the velocity of effector T cells was decreased with simultaneous increase in the proportion of stationary phase cells in the CNS. Based on these data, we conclude that regulatory T cells mediate recovery from experimental autoimmune encephalomyelitis by controlling cytokine production, proliferation and motility of effector T cells in the CNS.

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Title: Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS
Authors: Michail Koutrolos
Kerstin Berer
Naoto Kawakami
Hartmut Wekerle
Gurumoorthy Krishnamoorthy
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Acta Neuropathologica Communications / Issue 1/2014
Electronic ISSN: 2051-5960
DOI: https://doi.org/10.1186/s40478-014-0163-1

At a glance: The STEP trials

Springer Medicine

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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