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Open Access 01-12-2016 | Mini review

Can the preterm lung recover from perinatal stress?

Authors: Matthias C. Hütten, Tim G. A. M. Wolfs, Boris W. Kramer

Published in: Molecular and Cellular Pediatrics | Issue 1/2016

Abstract

After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfere with fetal and neonatal lung development. Prenatal insults like chorioamnionitis and prenatal interventions like maternal glucocorticosteroids interact but might also determine the preterm baby’s lung response to postnatal interventions (“second hit”) like supplementation of oxygen and drug therapy. We review current experimental and clinical findings on the influence of different perinatal factors on preterm lung development and discuss how well-established interventions in neonatal care might be adapted to attenuate postnatal lung injury.

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Title: Can the preterm lung recover from perinatal stress?
Authors: Matthias C. Hütten
Tim G. A. M. Wolfs
Boris W. Kramer
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2016
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-016-0043-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Can the preterm lung recover from perinatal stress?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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