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Molecular and Cellular Pediatrics

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Open Access 01-12-2015 | Minireview

GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn’s disease

Author: Jan Däbritz

Published in: Molecular and Cellular Pediatrics | Issue 1/2015

Abstract

Background

Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-stimulating factor (GM-CSF) exerts beneficial effects on intestinal inflammation and promotes signal transducer and activator of transcription 3 (STAT3)-mediated expansion of myeloid-derived suppressor cells (MDSCs). However, the full action mechanism of GM-CSF, and especially whether monocytes mediate its therapeutic effects in vivo, had not been previously elucidated.

Conclusions

This review article summarizes recent developments in the immunology of mucosal diseases and describes new aspects of the role of myeloid regulatory cells in IBD and the function of GM-CSF in maintaining the intestinal immune homeostasis in Crohn’s disease (CD). This review article highlights the exploration of stimulating in addition to suppressive therapies for patients with IBD and underpins that myeloid regulatory cells might become a promising novel cell-based therapeutic option.

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Title: GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn’s disease
Author: Jan Däbritz
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2015
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-015-0024-4

At a glance: The STEP trials

Springer Medicine

GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn’s disease

Abstract

Background

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Conclusions

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