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Translational Neurodegeneration
Published in: Translational Neurodegeneration 1/2015

Open Access 01-12-2015 | Review

The associations between Parkinson’s disease and cancer: the plot thickens

Authors: Danielle D. Feng, Waijiao Cai, Xiqun Chen

Published in: Translational Neurodegeneration | Issue 1/2015

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Abstract

Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation. Here, we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.
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Metadata
Title
The associations between Parkinson’s disease and cancer: the plot thickens
Authors
Danielle D. Feng
Waijiao Cai
Xiqun Chen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2015
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/s40035-015-0043-z

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