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Published in: European Journal of Medical Research 1/2021

Open Access 01-12-2021 | Adenovirus | Research

Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study

Authors: Bingke Bai, Zhe Xu, Yan Hu, Mengmeng Qu, Juan Cheng, Shengdong Luo, Zengtao Yao, Hongyan Gao, Yenv Ma, Rong Gao, Jun Hou, Shaojie Xin, Panyong Mao

Published in: European Journal of Medical Research | Issue 1/2021

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Abstract

Background

Hematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment.

Methods

In this retrospective case–control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza A (H1N1) in 2009, human adenovirus type 7 in 2018, and COVID-19 in 2020].

Results

One of the COVID-19 characteristics was a continuous decline in the hemoglobin level. The neutrophil count was related to the aggravation of COVID-19 and SARS. Thrombocytopenia occurred in patients with SARS and severe COVID-19 even at the recovery stage. Lymphocytes were related to the entire course of adenovirus infection, recovery of COVID-19, and disease development of SARS.

Conclusions

Dynamic changes in hematological counts could provide a reference for the pathogenesis and prognosis of pneumonia caused by respiratory viruses in clinics.
Literature
2.
go back to reference Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620–9.CrossRef Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620–9.CrossRef
3.
go back to reference Chen N, Zhou M, Dong X, Qu JM, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13.CrossRef Chen N, Zhou M, Dong X, Qu JM, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13.CrossRef
4.
go back to reference Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;324:782–93.CrossRef Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;324:782–93.CrossRef
5.
go back to reference Vaira LA, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M, et al. Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck. 2020;42:1560–9.CrossRef Vaira LA, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M, et al. Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck. 2020;42:1560–9.CrossRef
6.
go back to reference Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases. Head Neck. 2020;42:1252–8.CrossRef Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases. Head Neck. 2020;42:1252–8.CrossRef
7.
go back to reference De Vito A, Geremia N, Fiore V, Princic E, Babudieri S, Madeddu G. Clinical features, laboratory findings and predictors of death in hospitalized patients with COVID-19 in Sardinia, Italy. Eur Rev Med Pharmacol Sci. 2020;24:7861–8.PubMed De Vito A, Geremia N, Fiore V, Princic E, Babudieri S, Madeddu G. Clinical features, laboratory findings and predictors of death in hospitalized patients with COVID-19 in Sardinia, Italy. Eur Rev Med Pharmacol Sci. 2020;24:7861–8.PubMed
8.
go back to reference Guarneri C, Rullo EV, Pavone P, Berretta M, Ceccarelli M, Natale A, et al. Silent COVID-19: what your skin can reveal. Lancet Infect Dis. 2021;21:24–5.CrossRef Guarneri C, Rullo EV, Pavone P, Berretta M, Ceccarelli M, Natale A, et al. Silent COVID-19: what your skin can reveal. Lancet Infect Dis. 2021;21:24–5.CrossRef
9.
go back to reference Zinellu A, Arru F, De Vito A, Sassu A, Valdes G, Scano V, et al. The de ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients. Eur J Clin Invest. 2021;51:e13427.CrossRef Zinellu A, Arru F, De Vito A, Sassu A, Valdes G, Scano V, et al. The de ritis ratio as prognostic biomarker of in-hospital mortality in COVID-19 patients. Eur J Clin Invest. 2021;51:e13427.CrossRef
10.
go back to reference Bohmwald K, Galvez NMS, Rios M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386.CrossRef Bohmwald K, Galvez NMS, Rios M, Kalergis AM. Neurologic alterations due to respiratory virus infections. Front Cell Neurosci. 2018;12:386.CrossRef
11.
go back to reference Jartti T, Jartti L, Ruuskanen O, Soderlund-Venermo M. New respiratory viral infections. Curr Opin Pulm Med. 2012;18:271–8.CrossRef Jartti T, Jartti L, Ruuskanen O, Soderlund-Venermo M. New respiratory viral infections. Curr Opin Pulm Med. 2012;18:271–8.CrossRef
12.
go back to reference Vonesch N, Binazzi A, Bonafede M, Melis P, Ruggieri A, Iavicoli S, et al. Emerging zoonotic viral infections of occupational health importance. Pathog Dis. 2019;77:ftz018.CrossRef Vonesch N, Binazzi A, Bonafede M, Melis P, Ruggieri A, Iavicoli S, et al. Emerging zoonotic viral infections of occupational health importance. Pathog Dis. 2019;77:ftz018.CrossRef
13.
go back to reference Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007;445:319–23.CrossRef Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007;445:319–23.CrossRef
16.
go back to reference Chmielewicz B, Benzler J, Pauli G, Krause G, Bergmann F, Schweiger B. Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey. J Med Virol. 2005;77:232–7.CrossRef Chmielewicz B, Benzler J, Pauli G, Krause G, Bergmann F, Schweiger B. Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey. J Med Virol. 2005;77:232–7.CrossRef
17.
go back to reference Coleman KK, Wong CC, Jayakumar J, Nguyen TT, Wong AWL, Yadana S, et al. Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted? J Infect Dis. 2020;221:566–77.PubMed Coleman KK, Wong CC, Jayakumar J, Nguyen TT, Wong AWL, Yadana S, et al. Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted? J Infect Dis. 2020;221:566–77.PubMed
18.
go back to reference Xu L, Liu J, Liu C, Duan Y, Zhu Y, Xu B, et al. Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008–2013. BMC Infect Dis. 2018;18:634.CrossRef Xu L, Liu J, Liu C, Duan Y, Zhu Y, Xu B, et al. Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008–2013. BMC Infect Dis. 2018;18:634.CrossRef
19.
go back to reference Yang M, Li CK, Li K, Hon KLE, Ng MHL, Chan PKS, et al. Hematological findings in SARS patients and possible mechanisms (review). Int J Mol Med. 2004;14:311–5.PubMed Yang M, Li CK, Li K, Hon KLE, Ng MHL, Chan PKS, et al. Hematological findings in SARS patients and possible mechanisms (review). Int J Mol Med. 2004;14:311–5.PubMed
20.
go back to reference Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;58:1106–15.CrossRef Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;58:1106–15.CrossRef
21.
go back to reference Fois AG, Paliogiannis P, Scano V, Gau S, Babudieri S, Perra R, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules. 2020;25:5725.CrossRef Fois AG, Paliogiannis P, Scano V, Gau S, Babudieri S, Perra R, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules. 2020;25:5725.CrossRef
22.
go back to reference Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021;28:1–12. Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med. 2021;28:1–12.
23.
go back to reference Lai CY, Lee CJ, Lu CY, Lee PI, Shao PL, Wu ET, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010–2011. PLoS ONE. 2013;8:e53614.CrossRef Lai CY, Lee CJ, Lu CY, Lee PI, Shao PL, Wu ET, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010–2011. PLoS ONE. 2013;8:e53614.CrossRef
24.
go back to reference Paliogiannis P, Zinellu A, Scano V, Mulas G, De Riu G, Pascale RM, et al. Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report. J Infect Dev Ctries. 2020;14:685–90.CrossRef Paliogiannis P, Zinellu A, Scano V, Mulas G, De Riu G, Pascale RM, et al. Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report. J Infect Dev Ctries. 2020;14:685–90.CrossRef
25.
go back to reference Yin Z, Kang Z, Yang D, Ding S, Luo H, Xiao E. A comparison of clinical and chest CT findings in patients with influenza A (H1N1) virus infection and coronavirus disease (COVID-19). AJR Am J Roentgenol. 2020;215:1065–71.CrossRef Yin Z, Kang Z, Yang D, Ding S, Luo H, Xiao E. A comparison of clinical and chest CT findings in patients with influenza A (H1N1) virus infection and coronavirus disease (COVID-19). AJR Am J Roentgenol. 2020;215:1065–71.CrossRef
26.
go back to reference Jiang J, Wan R, Pan P, Hu C, Zhou R, Yin Y, et al. Comparison of clinical, laboratory and radiological characteristics between COVID-19 and adenovirus pneumonia: a retrospective study. Infect Drug Resist. 2020;13:3401–8.CrossRef Jiang J, Wan R, Pan P, Hu C, Zhou R, Yin Y, et al. Comparison of clinical, laboratory and radiological characteristics between COVID-19 and adenovirus pneumonia: a retrospective study. Infect Drug Resist. 2020;13:3401–8.CrossRef
27.
go back to reference Mahase E. Covid-19: outbreak could last until Spring 2021 and see 7.9 million hospitalised in the UK. BMJ. 2020;368:m1071.CrossRef Mahase E. Covid-19: outbreak could last until Spring 2021 and see 7.9 million hospitalised in the UK. BMJ. 2020;368:m1071.CrossRef
28.
go back to reference Wu X, Cai Y, Huang X, Yu X, Zhao L, Wang F, et al. Co-infection with SARS-CoV-2 and influenza A virus in patient with pneumonia. China Emerg Infect Dis. 2020;26:1324–6.CrossRef Wu X, Cai Y, Huang X, Yu X, Zhao L, Wang F, et al. Co-infection with SARS-CoV-2 and influenza A virus in patient with pneumonia. China Emerg Infect Dis. 2020;26:1324–6.CrossRef
29.
go back to reference Méndez R, Menéndez R, Amara-Elori I, Feced L, Piro A, Ramirez P, et al. Lymphopenic community acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Infect. 2019;78:423–31.CrossRef Méndez R, Menéndez R, Amara-Elori I, Feced L, Piro A, Ramirez P, et al. Lymphopenic community acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality. J Infect. 2019;78:423–31.CrossRef
30.
go back to reference Zhou F, Li H, Gu L, Liu M, Xue CX, Cao B, et al. Risk factors for nosocomial infection among hospitalised severe influenza A (H1N1)pdm09 patients. Respir Med. 2018;134:86–91.CrossRef Zhou F, Li H, Gu L, Liu M, Xue CX, Cao B, et al. Risk factors for nosocomial infection among hospitalised severe influenza A (H1N1)pdm09 patients. Respir Med. 2018;134:86–91.CrossRef
31.
go back to reference Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, et al. Infectious progeny of 2009 A (H1N1) influenza virus replicated in and released from human neutrophils. Sci Rep. 2015;5:17809.CrossRef Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, et al. Infectious progeny of 2009 A (H1N1) influenza virus replicated in and released from human neutrophils. Sci Rep. 2015;5:17809.CrossRef
32.
go back to reference Malachowa N, Freedman B, Sturdevant DE, Kobayashi SD, Nair V, Feldman F, et al. Differential ability of pandemic and seasonal H1N1 influenza A viruses to alter the function of human neutrophils. mSphere. 2018;3:e00567-e617.CrossRef Malachowa N, Freedman B, Sturdevant DE, Kobayashi SD, Nair V, Feldman F, et al. Differential ability of pandemic and seasonal H1N1 influenza A viruses to alter the function of human neutrophils. mSphere. 2018;3:e00567-e617.CrossRef
33.
go back to reference Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol. 2008;82:2772–83.CrossRef Fujisawa H. Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol. 2008;82:2772–83.CrossRef
34.
go back to reference Guo L, Rondina MT. The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases. Front Immunol. 2019;10:2204.CrossRef Guo L, Rondina MT. The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases. Front Immunol. 2019;10:2204.CrossRef
35.
go back to reference Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145–8.CrossRef Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta. 2020;506:145–8.CrossRef
36.
go back to reference Subramaniam S, Scharrer I. Procoagulant activity during viral infections. Front Biosci. 2018;23:1060–81.CrossRef Subramaniam S, Scharrer I. Procoagulant activity during viral infections. Front Biosci. 2018;23:1060–81.CrossRef
37.
go back to reference Yang M, Ng MHL, Li CK. Thrombocytopenia in patients with severe acute respiratory syndrome (review). Hematology. 2005;10:101–5.CrossRef Yang M, Ng MHL, Li CK. Thrombocytopenia in patients with severe acute respiratory syndrome (review). Hematology. 2005;10:101–5.CrossRef
38.
go back to reference Yang J, Yang M, Xu F, Li K, Lee SKM, Ng PC, et al. Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model. Pediatr Res. 2003;54:344–52.CrossRef Yang J, Yang M, Xu F, Li K, Lee SKM, Ng PC, et al. Effects of oxygen-induced lung damage on megakaryocytopoiesis and platelet homeostasis in a rat model. Pediatr Res. 2003;54:344–52.CrossRef
39.
go back to reference Chen SY, Su CP, Ma MH, Chiang WC, Hsu CY, Ko CI, et al. Predictive model of diagnosing probable cases of severe acute respiratory syndrome in febrile patients with exposure risk. Ann Emerg Med. 2004;43:1–5.CrossRef Chen SY, Su CP, Ma MH, Chiang WC, Hsu CY, Ko CI, et al. Predictive model of diagnosing probable cases of severe acute respiratory syndrome in febrile patients with exposure risk. Ann Emerg Med. 2004;43:1–5.CrossRef
40.
go back to reference Lamichhane PP, Boonnak K, Changsom D, Noisumdaeng P, Sangsiriwut K, Pattanakistakul SN, et al. H5N1 NS genomic segment distinctly governs the influenza virus infectivity and cytokine induction in monocytic cells. Asian Pac J Allergy Immunol. 2018;36:58–68.PubMed Lamichhane PP, Boonnak K, Changsom D, Noisumdaeng P, Sangsiriwut K, Pattanakistakul SN, et al. H5N1 NS genomic segment distinctly governs the influenza virus infectivity and cytokine induction in monocytic cells. Asian Pac J Allergy Immunol. 2018;36:58–68.PubMed
41.
go back to reference Cline TD, Beck D, Bianchini E. Influenza virus replication in macrophages: balancing protection and pathogenesis. J Gen Virol. 2017;98:2401–12.CrossRef Cline TD, Beck D, Bianchini E. Influenza virus replication in macrophages: balancing protection and pathogenesis. J Gen Virol. 2017;98:2401–12.CrossRef
Metadata
Title
Patient hematology during hospitalization for viral pneumonia caused by SARS-CoV-2 and non-SARS-CoV-2 agents: a retrospective study
Authors
Bingke Bai
Zhe Xu
Yan Hu
Mengmeng Qu
Juan Cheng
Shengdong Luo
Zengtao Yao
Hongyan Gao
Yenv Ma
Rong Gao
Jun Hou
Shaojie Xin
Panyong Mao
Publication date
01-12-2021
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-021-00515-9

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