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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2021

Open Access 01-12-2021 | Polytrauma | Research

The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome

Authors: Julian Haupt, Niels Krysiak, Marina Unger, Viktoria Bogner-Flatz, Peter Biberthaler, Marc Hanschen, Martijn van Griensven, Alexander T. Haug

Published in: European Journal of Medical Research | Issue 1/2021

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Abstract

Background

Multiple organ dysfunction syndrome (MODS) and the consecutive multiple organ failure (MOF) are severe and dreaded complications with a high mortality in multiple trauma patients. The aim of this study was to investigate the potential of the adipokines leptin, resistin, interleukin-17A and interleukin-33 as possible biomarkers in the early posttraumatic inflammatory response and for identifying severely traumatized patients at risk of developing MODS.

Methods

In total, 14 multiple trauma patients with an injury severity score (ISS) ≥ 16 as well as a control group of 14 non-multiple trauma patients were included in this study and blood samples were taken at the time points 0, 6, 24, 48 and 72 h after admission. For the trauma patients, the SIRS and Denver MOF score were determined daily. The quantitative measurement of the plasma concentrations of the adipokines was performed using ELISA.

Results

In the statistical analysis, the multiple trauma patients showed statistically significant higher plasma concentrations of leptin, resistin, IL-17A and IL-33 compared to the control group. In addition, there was a statistically significant positive correlation between the concentrations of resistin, IL-17A and IL-33 and the corresponding SIRS scores and between the concentrations of resistin, IL-17A and IL-33 and the corresponding Denver MOF scores. Finally, ROC curve analysis revealed that the adipokines leptin and IL-17A are suitable diagnostic markers for the discrimination between multiple trauma patients with and without MOF.

Conclusions

Leptin and IL-17A could be suitable diagnostic markers to identify severely injured patients with a developing SIRS and MOF earlier, to adjust surgical therapy planning and intensive care.
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Metadata
Title
The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome
Authors
Julian Haupt
Niels Krysiak
Marina Unger
Viktoria Bogner-Flatz
Peter Biberthaler
Marc Hanschen
Martijn van Griensven
Alexander T. Haug
Publication date
01-12-2021
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-021-00511-z

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