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Published in: European Journal of Medical Research 1/2020

Open Access 01-12-2020 | SARS-CoV-2 | Research

Clinical, epidemiological, and laboratory characteristics of mild-to-moderate COVID-19 patients in Saudi Arabia: an observational cohort study

Authors: Abbas Al Mutair, Saad Alhumaid, Waad N. Alhuqbani, Abdul Rehman Z. Zaidi, Safug Alkoraisi, Maha F. Al-Subaie, Alanoud M. AlHindi, Ahmed K. Abogosh, Aljwhara K. Alrasheed, Aya A. Alsharafi, Mohammed N. Alhuqbani, Njoud A. Alhowar, Samer Salih, Mogbil A. Alhedaithy, Jaffar A. Al-Tawfiq, Haifa Al-Shammari, Rayid Abdulqawi, Alaa F. Ismail, Noura Hamdan, Fares Saad, Fahad A. Olhaye, Tarig A. Eltahir, Ali A. Rabaan, Awad Al-Omari

Published in: European Journal of Medical Research | Issue 1/2020

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Abstract

Background

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged from China in December 2019 and has presented as a substantial and serious threat to global health. We aimed to describe the clinical, epidemiological, and laboratory findings of patients in Saudi Arabia infected with SARS-CoV-2 to direct us in helping prevent and treat coronavirus disease 2019 (COVID-19) across Saudi Arabia and around the world.

Materials and methods

Clinical, epidemiological, laboratory, and radiological characteristics, treatment, and outcomes of pediatric and adult patients in five hospitals in Riyadh, Saudi Arabia, were surveyed in this study.

Results

401 patients (mean age 38.16 ± 13.43 years) were identified to be SARS-CoV-2 positive and 80% of cases were male. 160 patients had moderate severity and 241 were mild in severity. The most common signs and symptoms at presentation were cough, fever, fatigue, and shortness of breath. Neutrophil and lymphocyte counts, aspartate aminotransferase, C-reactive protein, and ferritin were higher in the COVID-19 moderate severity patient group. Mild severity patients spent a shorter duration hospitalized and had slightly higher percentages of abnormal CT scans and X-ray imaging.

Conclusions

This study provides an understanding of the features of non-ICU COVID-19 patients in Saudi Arabia. Further national collaborative studies are needed to streamline screening and treatment procedures for COVID-19.
Literature
1.
go back to reference Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002;21(16):2409–19.CrossRef Heinze G, Schemper M. A solution to the problem of separation in logistic regression. Stat Med. 2002;21(16):2409–19.CrossRef
2.
go back to reference Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–15.CrossRef Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809–15.CrossRef
3.
go back to reference Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136(4):489–500.CrossRef Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136(4):489–500.CrossRef
4.
go back to reference Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517–20.CrossRef Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 2020;395(10235):1517–20.CrossRef
5.
go back to reference Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, et al. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. J Am Soc Nephrol. 2020;31(7):1380.CrossRef Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, et al. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. J Am Soc Nephrol. 2020;31(7):1380.CrossRef
6.
go back to reference Albalawi M, Zaidi SZA, AlShehry N, AlAskar A, Zaidi ARZ, Abdallah RNM, et al. Safety and efficacy of convalescent plasma to treat severe COVID-19: protocol for the saudi collaborative multi-center phase II study. JMIR Res Protocols. 2020;9(10):e23543.CrossRef Albalawi M, Zaidi SZA, AlShehry N, AlAskar A, Zaidi ARZ, Abdallah RNM, et al. Safety and efficacy of convalescent plasma to treat severe COVID-19: protocol for the saudi collaborative multi-center phase II study. JMIR Res Protocols. 2020;9(10):e23543.CrossRef
7.
go back to reference Quah P, Li A, Phua J. Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature. Crit Care. 2020;24(1):285.CrossRef Quah P, Li A, Phua J. Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature. Crit Care. 2020;24(1):285.CrossRef
8.
go back to reference Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England J Med. 2020;382(18):1708–20.CrossRef Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England J Med. 2020;382(18):1708–20.CrossRef
9.
go back to reference Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, et al. Characteristics and outcomes of 21 Critically Ill patients with COVID-19 in Washington State. JAMA. 2020;323(16):1612–4.CrossRef Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, et al. Characteristics and outcomes of 21 Critically Ill patients with COVID-19 in Washington State. JAMA. 2020;323(16):1612–4.CrossRef
10.
go back to reference Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang. China J Infect. 2020;80(4):388–93.CrossRef Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang. China J Infect. 2020;80(4):388–93.CrossRef
12.
go back to reference Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) Outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–42.CrossRef Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) Outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–42.CrossRef
13.
go back to reference Xu J, Yang X, Yang L, Zou X, Wang Y, Wu Y, et al. Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China. Crit Care. 2020;24(1):394.CrossRef Xu J, Yang X, Yang L, Zou X, Wang Y, Wu Y, et al. Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China. Crit Care. 2020;24(1):394.CrossRef
14.
go back to reference Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan China. The Lancet. 2020;395(10223):497–506.CrossRef Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan China. The Lancet. 2020;395(10223):497–506.CrossRef
15.
go back to reference Al-Omari A, Alhuqbani WN, Zaidi ARZ, Al-Subaie MF, AlHindi AM, Abogosh AK, et al. Clinical characteristics of non-intensive care unit COVID-19 patients in Saudi Arabia: a descriptive cross-sectional study. J Infect Public Health. 2020;13:1639–44.CrossRef Al-Omari A, Alhuqbani WN, Zaidi ARZ, Al-Subaie MF, AlHindi AM, Abogosh AK, et al. Clinical characteristics of non-intensive care unit COVID-19 patients in Saudi Arabia: a descriptive cross-sectional study. J Infect Public Health. 2020;13:1639–44.CrossRef
16.
go back to reference Kempker JA, Martin GS. A global accounting of sepsis. The Lancet. 2020;395(10219):168–70.CrossRef Kempker JA, Martin GS. A global accounting of sepsis. The Lancet. 2020;395(10219):168–70.CrossRef
17.
go back to reference Liu D, Wang Q, Zhang H, Cui L, Shen F, Chen Y, et al. Viral sepsis is a complication in patients with Novel Corona Virus Disease (COVID-19). Med Drug Discovery. 2020;8:100057.CrossRef Liu D, Wang Q, Zhang H, Cui L, Shen F, Chen Y, et al. Viral sepsis is a complication in patients with Novel Corona Virus Disease (COVID-19). Med Drug Discovery. 2020;8:100057.CrossRef
18.
go back to reference Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet. 2020;395(10219):200–11.CrossRef Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet. 2020;395(10219):200–11.CrossRef
19.
go back to reference Wang G, Wu C, Zhang Q, Wu F, Yu B, Lv J, et al., editors. C-Reactive Protein Level May Predict the Risk of COVID-19 Aggravation. Open Forum Infectious Diseases; 2020: Oxford University Press US. Wang G, Wu C, Zhang Q, Wu F, Yu B, Lv J, et al., editors. C-Reactive Protein Level May Predict the Risk of COVID-19 Aggravation. Open Forum Infectious Diseases; 2020: Oxford University Press US.
20.
go back to reference Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in Critically Ill Patients in the Seattle Region—Case Series. N Engl J Med. 2020;382(21):2012–22.CrossRef Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in Critically Ill Patients in the Seattle Region—Case Series. N Engl J Med. 2020;382(21):2012–22.CrossRef
21.
go back to reference Wu C, Chen X, Cai Y, Xia JA, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan. China JAMA Internal Med. 2020;180(7):934–43.CrossRef Wu C, Chen X, Cai Y, Xia JA, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan. China JAMA Internal Med. 2020;180(7):934–43.CrossRef
22.
go back to reference Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan. China Jama. 2020;323(11):1061–9.CrossRef Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan. China Jama. 2020;323(11):1061–9.CrossRef
23.
go back to reference Fu EL, Janse RJ, de Jong Y, van der Endt VHW, Milders J, van der Willik EM, et al. Acute kidney injury and kidney replacement therapy in COVID-19: a systematic review and meta-analysis. Clin Kidney J. 2020;13(4):550–63.CrossRef Fu EL, Janse RJ, de Jong Y, van der Endt VHW, Milders J, van der Willik EM, et al. Acute kidney injury and kidney replacement therapy in COVID-19: a systematic review and meta-analysis. Clin Kidney J. 2020;13(4):550–63.CrossRef
24.
go back to reference Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052–9.CrossRef Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052–9.CrossRef
28.
go back to reference Alhazzani W, Al-Suwaidan F, Al Aseri Z, Al Mutair A, Alghamdi G, Rabaan A, et al. The saudi critical care society clinical practice guidelines on the management of COVID-19 patients in the intensive care unit. Saudi Criti Care J. 2020;4(2):27–44.CrossRef Alhazzani W, Al-Suwaidan F, Al Aseri Z, Al Mutair A, Alghamdi G, Rabaan A, et al. The saudi critical care society clinical practice guidelines on the management of COVID-19 patients in the intensive care unit. Saudi Criti Care J. 2020;4(2):27–44.CrossRef
Metadata
Title
Clinical, epidemiological, and laboratory characteristics of mild-to-moderate COVID-19 patients in Saudi Arabia: an observational cohort study
Authors
Abbas Al Mutair
Saad Alhumaid
Waad N. Alhuqbani
Abdul Rehman Z. Zaidi
Safug Alkoraisi
Maha F. Al-Subaie
Alanoud M. AlHindi
Ahmed K. Abogosh
Aljwhara K. Alrasheed
Aya A. Alsharafi
Mohammed N. Alhuqbani
Njoud A. Alhowar
Samer Salih
Mogbil A. Alhedaithy
Jaffar A. Al-Tawfiq
Haifa Al-Shammari
Rayid Abdulqawi
Alaa F. Ismail
Noura Hamdan
Fares Saad
Fahad A. Olhaye
Tarig A. Eltahir
Ali A. Rabaan
Awad Al-Omari
Publication date
01-12-2020
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2020
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-020-00462-x

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