01-12-2020 | Mycobacterium Tuberculosis | Correction
Correction to: Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB
Published in: European Journal of Medical Research | Issue 1/2020
Login to get accessExcerpt
The original publication of this article [1] contained few erroneous paragraphs and errors in Table 1 and Table 2. The first four paragraphs are in the ‘Results’ section while the last four paragraphs are in the ‘Discussion’ section. The errors in Table 1 involve the number of isolates tested for pyrazinamide and pyrazinamide susceptible isolates, ethambutol-susceptible isolates with a mutation and number of resistant isolates with a mutation for streptomycin. The error in Table 2 involves wrong codon number for a mutation in isolate KM17-01 in Cluster XII for gidB gene. The updated informations have been indicated in bold and also refer corrected Tables 1 and 2.
Table 1
Phenotypic resistance by MGIT 960 system to anti-TB drugs among 93 multidrug-resistant M. tuberculosis isolates and number of susceptible and resistant isolates with mutations in target genes for each drug
Anti-tuberculosis drug
|
No. of isolates tested
|
No. of susceptible isolates
|
No. of susceptible isolates with mutationa
|
No. of resistant isolates
|
No. (%) of resistant isolates with mutationa
|
---|---|---|---|---|---|
Rifampicin
|
93
|
0
|
0
|
93
|
93 (100)
|
Isoniazid
|
93
|
0
|
0
|
93
|
92 (98.9)
|
Pyrazinamide
|
46
|
10
|
0
|
36
|
30 (83.3)
|
Ethambutol
|
93
|
52
|
39b
|
41
|
38 (92.7)
|
Streptomycin
|
93
|
34
|
0
|
59
|
51 (86.4)
|
Table 2
Detailed clinical, demographic and molecular characteristics of 42 M. tuberculosis isolates in 16 (Cluster I to Cluster XVI) clusters
Cluster no.
|
Clinica specimen
|
Isolate no.
|
Year of isolation
|
Patient’s nationality
|
Spoligotyping data
|
Genetic alteration detected in
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SIT
|
Mtb family
|
rpoB
|
katG
|
inhA
|
pncA
|
embB
|
rpsL
|
rrs
|
gidB
|
rpsA
|
|||||
I
|
Sputum
|
KM06-153
|
2006
|
Indian
|
255
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
ATG306GTG
|
AAG43AGG
|
WT
|
N. D.
|
N. D.
|
CSF
|
KM09-22
|
2009
|
Indian
|
255
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
ATG306GTG
|
AAG43AGG
|
WT
|
N. D.
|
N. D.
|
|
Sputum
|
KM13-37
|
2013
|
Indian
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
ATG306GTG
|
AAG43AGG
|
WT
|
N. D.
|
N. D.
|
|
FNA
|
KM16-06
|
2016
|
Nepalese
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
ATG306GTG
|
AAG43AGG
|
WT
|
N. D.
|
N. D.
|
|
FNA
|
KM17-03
|
2017
|
Indian
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
ATG306GTG
|
AAG43AGG
|
WT
|
N. D.
|
N. D.
|
|
II
|
Sputum
|
KM14-58
|
2014
|
Nepalese
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
GTG139GCG
|
ATG306GTG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
Sputum
|
KM14-69
|
2014
|
Indian
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
GTG139GCG
|
ATG306GTG
|
AAG43AGG
|
WT
|
GCA205GCG
|
WT
|
|
III
|
Sputum
|
KM08-501
|
2008
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
GGT139GTT
|
ATG306GTG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
Sputum
|
KM08-502
|
2008
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
GGT139GTT
|
ATG306GTG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
Sputum
|
KM09-207
|
2009
|
Indian
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
GGT139GTT
|
ATG306GTG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
IV
|
Sputum
|
KM12-05
|
2012
|
Ethiopian
|
21
|
CAS1-Kili
|
TCG456TTG
|
ACG315ACC
|
WT
|
Ins193A (FS) + TCC65TCT
|
ATG306GTG
|
AAG88AGG
|
WT
|
N. D.
|
N. D.
|
Sputum
|
KM12-17
|
2012
|
Ethiopian
|
1144
|
T1
|
TCG456TTG
|
ACG315ACC
|
WT
|
Ins193A (FS) + TCC65TCT
|
ATG306GTG
|
AAG88AGG
|
WT
|
N. D.
|
N. D.
|
|
Sputum
|
KM15-08
|
2015
|
Ethiopian
|
21
|
CAS1-Kili
|
TCG456TTG
|
ACG315ACC
|
WT
|
Ins193A (FS) + TCC65TCT
|
ATG306GTG
|
AAG88AGG
|
WT
|
N. D.
|
N. D.
|
|
V
|
Sputum
|
KM07-333
|
2007
|
Indonesian
|
Orphan
|
N. A.
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
Sputum
|
KM10-23
|
2010
|
Indian
|
355
|
EAI3-IND
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
|
VI
|
Sputum
|
KM07-293
|
2007
|
Filipino
|
194
|
LAM2
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
CAG497CGG
|
WT
|
WT
|
N. D.
|
N. D.
|
Sputum
|
KM12-01
|
2012
|
Filipino
|
25
|
CAS1-Delhi
|
TCG456TTG
|
ACG315ACC
|
WT
|
WT
|
CAG497CGG
|
WT
|
WT
|
N. D.
|
N. D.
|
|
VII
|
Sputum
|
KM09-202
|
2009
|
Ethiopian
|
47
|
H1
|
GTC176TTC
|
ACG315ACC
|
WT
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
Sputum
|
KM15-17
|
2015
|
Indian
|
47
|
H1
|
GTC176TTC
|
ACG315ACC
|
WT
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
|
VIII
|
Sputum
|
KM14-67
|
2014
|
Ethiopian
|
149
|
T3-ETH
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
ATG306ATC
|
WT
|
WT
|
GGT69GAT
|
WT
|
Sputum
|
KM15-21
|
2015
|
Ethiopian
|
149
|
T3-ETH
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
ATG306ATC
|
WT
|
WT
|
GGT69GAT
|
WT
|
|
IX
|
Sputum
|
KM07-283
|
2007
|
Indian
|
26
|
CAS1-Delhi
|
TCG456TTG
|
ACG315ACC
|
WT
|
TCC65TCT
|
ATG306ATA
|
WT
|
WT
|
N. D.
|
N. D.
|
Sputum
|
KM14-68
|
2014
|
Indian
|
Orphan
|
N. A.
|
TCG456TTG
|
ACG315ACC
|
WT
|
TCC65TCT
|
ATG306ATA
|
WT
|
WT
|
N. D.
|
N. D.
|
|
Sputum
|
KM17-20
|
2017
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
CAG497CGG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
WT
|
|
X
|
Sputum
|
KM17-22
|
2017
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
CAG497CGG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
Sputum
|
KM17-73
|
2017
|
Indian
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
CAG497CGG
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
Pus
|
KM11-503
|
2011
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
Sputum
|
KM14-56
|
2014
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
XI
|
Sputum
|
KM15-13
|
2015
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
Sputum
|
KM15-26
|
2015
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
Sputum
|
KM17-02
|
2015
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
Sputum
|
KM17-69
|
2017
|
Kuwaiti
|
1
|
Beijing
|
TCG456TTG
|
ACG315ACC
|
WT
|
− 11 A/G
|
GGC406GAC
|
AAG43AGG
|
WT
|
GAA92GAC + GCA205GCG
|
CGA212CGC
|
|
XII
|
Sputum
|
KM16-32
|
2016
|
Egyptian
|
19
|
EAI2-Manila
|
CAC451TAC
|
ACG315ACC
|
− 15 C/T
|
GAA37AAA
|
CTG355CTA + GAG378GCG
|
WT
|
WT
|
GTG110GTT + GCA205GCG
|
WT
|
Sputum
|
KM17-01
|
2017
|
Filipino
|
19
|
EAI2-Manila
|
CAC451TAC
|
ACG315ACC
|
− 15 C/T
|
GAA37AAA
|
CTG355CTA + GAG378GCG
|
WT
|
WT
|
CTC59TTC + GTG110GTT + GCA205GCG
|
WT
|
|
XIII
|
Pus
|
KM07-297
|
2007
|
Indian
|
Orphan
|
N. A.
|
CAC451GAC
|
WT
|
− 15 C/T
|
TCC65TCG + Ins 453T (FS)
|
ATG306CTG
|
WT
|
WT
|
N. D.
|
N. D.
|
FNA
|
KM11-502
|
2015
|
Indian
|
3361
|
T1
|
CAC451GAC
|
WT
|
− 15 C/T
|
TCC65TCG + Ins 453T (FS)
|
ATG306CTG
|
WT
|
WT
|
N. D.
|
N. D.
|
|
XIV
|
Sputum
|
KM06-48
|
2006
|
Egyptian
|
53
|
T1
|
TCG456TTG
|
WT
|
− 15 C/T
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
Tissue
|
KM06-277
|
2006
|
Filipino
|
19
|
EAI2-Manila
|
TCG456TTG
|
WT
|
− 15 C/T
|
WT
|
WT
|
WT
|
WT
|
N. D.
|
N. D.
|
|
XV
|
Sputum
|
KM16-33
|
2016
|
Indian
|
8
|
EAI3/EAI5
|
CAC451TAC
|
ACG315ACC
|
WT
|
CTG35CCG
|
ATG306GTG + GAG378GCG
|
AAG43AGG
|
WT
|
GTG110GTT + GCA205GCG
|
WT
|
Sputum
|
KM17-06
|
2017
|
Filipino
|
8
|
EAI3/EAI5
|
CAC451TAC
|
ACG315ACC
|
WT
|
CTG35CCG
|
ATG306GTG + GAG378GCG
|
AAG43AGG
|
WT
|
GTG110GTT + GCA205GCG
|
WT
|
|
XVI
|
Sputum
|
KM07-231
|
2007
|
Indian
|
Orphana
|
CAS1-Delhi
|
ATG440ATA + GAC441TAC
|
ACG315ACC
|
WT
|
TCC65TCT
|
GGC406TGC
|
WT
|
WT
|
GCA205GCG + Del 350G (FS)
|
WT
|
Sputum
|
KM07-252
|
2007
|
Syrian
|
Orphana
|
CAS1-Delhi
|
ATG440ATA + GAC441TAC
|
ACG315ACC
|
WT
|
TCC65TCT
|
GGC406TGC
|
WT
|
WT
|
GCA205GCG + Del 350G (FS)
|
WT
|