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European Journal of Medical Research

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Open Access 01-12-2016 | Research

Clinical application of computed tomography-guided ¹²⁵I seed interstitial implantation for head and neck cancer patients with unmanageable cervical lymph node metastases

Authors: Hai Huang, Shaonian Xu, Fusheng Li, Zhenguang Du, Liang Wang

Published in: European Journal of Medical Research | Issue 1/2016

Abstract

Background

To assess clinical application of computed tomography (CT)-guided ¹²⁵I seed implantation for patients who cannot endure or unwillingly receive repeated surgery, chemotherapy, or radiotherapy for unmanageable cervical lymph node metastases in head and neck cancer (HNC).

Methods

Thirty-one consecutive patients received CT-guided ¹²⁵I seed implantation between February 2010 and December 2013. To evaluate the clinical efficiency, karnofsky performance score (KPS), numeric rating scale (NRS), and tumor volume at 3-, and 6-month post-implantation were compared with pre-implantation, along with local control rate (LCR), overall survival rate (OSR), and complications at 3, 6 months, 1, and 2 years.

Results

The tumor volume was obviously decreased at 3-, and 6-month post-implantation (21.23 ± 8.83 versus 9.19 ± 7.52 cm²; 21.23 ± 8.83 versus 6.42 ± 9.79 cm²; P < 0.05) compared with pre-implantation. The NRS was statistically reduced (3.06 ± 1.06 versus 7.77 ± 0.92; 2.39 ± 1.15 versus 7.77 ± 0.92; P < 0.05), while KPS was significantly improved (83.18 ± 5.97 versus 73.60 ± 7.90; 82.86 ± 5.43 versus 73.60 ± 7.90; P < 0.05) postoperatively at 3 and 6 months, respectively. The LCR at 3, 6 months, 1, and 2 years was 96.30, 83.87, 64.51, and 45.16 %, respectively. The OSR was 100, 100, 67.74, and 45.16 %, respectively. Three cases experienced grade I and two had grade II acute radiation toxicity.

Conclusions

CT-guided seed implantation may be feasible and safe for HNC patients whose neck nodes are not manageable by routine strategies with fewer complications, higher LCR, and significant pain relief.

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Title: Clinical application of computed tomography-guided 125I seed interstitial implantation for head and neck cancer patients with unmanageable cervical lymph node metastases
Authors: Hai Huang
Shaonian Xu
Fusheng Li
Zhenguang Du
Liang Wang
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2016
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-016-0213-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Clinical application of computed tomography-guided ¹²⁵I seed interstitial implantation for head and neck cancer patients with unmanageable cervical lymph node metastases

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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