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Addiction Science & Clinical Practice
Published in: Addiction Science & Clinical Practice 1/2015

Open Access 01-12-2015 | Research

Factors associated with willingness to take extended release naltrexone among injection drug users

Authors: Keith Ahamad, MJ Milloy, Paul Nguyen, Sasha Uhlmann, Cheyenne Johnson, Todd P Korthuis, Thomas Kerr, Evan Wood

Published in: Addiction Science & Clinical Practice | Issue 1/2015

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Abstract

Background

Although opioid-agonist therapy with methadone or buprenorphine/naloxone is currently the mainstay of medical treatment for opioid use disorder, these medications often are not well accepted or tolerated by patients. Recently, extended release naltrexone (XR-NTX), an opioid antagonist, has been advanced as an alternative treatment. The willingness of opioid-addicted patients to take XR-NTX has not been well described.

Methods

Opioid-using persons enrolled in a community-recruited cohort in Vancouver, Canada, were asked whether or not they would be willing to take XR-NTX. Logistic regression was used to independently identify factors associated with willingness to take the medication.

Results

Among the 657 participants surveyed between June 1, 2013, and November 30, 2013, 342 (52.1%) were willing to take XR-NTX. One factor positively associated with willingness was daily heroin injection (adjusted odds ratio [AOR] = 1.53; 95% confidence interval [CI] = 1.02–2.31), whereas Caucasian ethnicity was negatively associated (AOR = 0.59; 95% CI = 0.43–0.82). Satisfaction with agonist therapy (13.4%) and unwillingness to stop opioids being used for pain (26.9%) were the most common reasons for being unwilling to take XR-NTX.

Conclusions

A high level of willingness to take XR-NTX was observed in this setting. Interestingly, daily injection heroin use was positively associated with willingness, whereas Caucasian participants were less willing to take XR-NTX. Although explanations for unwillingness were described in this study, further research is needed to investigate real-world acceptability of XR-NTX as an additional option for the treatment of opioid use disorder.
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Metadata
Title
Factors associated with willingness to take extended release naltrexone among injection drug users
Authors
Keith Ahamad
MJ Milloy
Paul Nguyen
Sasha Uhlmann
Cheyenne Johnson
Todd P Korthuis
Thomas Kerr
Evan Wood
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Addiction Science & Clinical Practice / Issue 1/2015
Electronic ISSN: 1940-0640
DOI
https://doi.org/10.1186/s13722-015-0034-5

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