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Systematic Reviews
Published in: Systematic Reviews 1/2021

Open Access 01-12-2021 | Glucocorticoid | Research

A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis

Authors: Adeleh Sahebnasagh, Paria Soltani Nejad, Amin Salehi-Abargouei, Mohammad Hossein Dehghani, Fatemeh Saghafi

Published in: Systematic Reviews | Issue 1/2021

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Abstract

Background

Cardiopulmonary arrest (CPA) is an urgency, which is associated with high mortality. This systematic review evaluated the relationship between baseline cortisol level and the outcome of resuscitated CPA patients.

Methods

We searched the following databases: PubMed, Scopus, ISI Web of Science, and Google Scholar. Relevant observational and controlled trials were explored from inception by April 2020. The quality of the articles was assessed using the Newcastle-Ottawa Scale (NOS).

Results

Finally, five cohort studies (n = 201 participants in total) were eligible for including in the meta-analysis. The results of this meta-analysis showed that although the baseline serum cortisol levels were higher in survivors of cardiac arrest compared with non-survivors, the differences between groups do not reach a significance level (Hedges’ g = 0.371, 95% CI, −0.727, 1.469, P value = 0.508). Between-study heterogeneity was statistically significant (Cochrane Q test: P value < 0.001, I2 = 89.323).

Conclusions

The result of the present meta-analysis was suggestive of a higher baseline serum cortisol levels in survivors of CPA. Future randomized controlled studies with a large sample size will determine the exact relationship between adrenal reservation and the eventual outcome of patients with CPA.

Systematic review registration

PROSPERO CRD42018085468
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Metadata
Title
A characterization of cortisol level and adrenal reservation in human cardiopulmonary arrest: systematic review and meta-analysis
Authors
Adeleh Sahebnasagh
Paria Soltani Nejad
Amin Salehi-Abargouei
Mohammad Hossein Dehghani
Fatemeh Saghafi
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Glucocorticoid
Published in
Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-021-01820-4

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