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Open Access 01-12-2021 | Probiotics | Research

Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

Authors: Najmeh Seifi, Ali Jafarzadeh Esfahani, Alireza Sedaghat, Reza Rezvani, Majid Khadem-Rezaiyan, Mohsen Nematy, Mohammad Safarian

Published in: Systematic Reviews | Issue 1/2021

Abstract

Purpose

The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally fed critically ill adult patients.

Methods

MEDLINE, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally fed critically ill adult patients were included.

Results

Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU).

Conclusion

It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro, or synbiotics have no significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.

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Title: Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review
Authors: Najmeh Seifi
Ali Jafarzadeh Esfahani
Alireza Sedaghat
Reza Rezvani
Majid Khadem-Rezaiyan
Mohsen Nematy
Mohammad Safarian
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Probiotics
Care
Diarrhea
Respiratory Microbiota
Diarrhea
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-021-01633-5

At a glance: The STEP trials

Springer Medicine

Effect of gut microbiota modulation on feeding tolerance of enterally fed critically ill adult patients: a systematic review

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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