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Systematic Reviews
Published in: Systematic Reviews 1/2021

Open Access 01-12-2021 | Cystic Fibrosis | Protocol

The impact of physical activity and exercise interventions for physical health in people with cystic fibrosis: protocol for a systematic review

Authors: Owen W. Tomlinson, Sarah Denford, Alan R. Barker, Jane E. Schneiderman, Emma S. Campisi, Helen Douglas, Sarah Rand, Melitta A. McNarry, Kelly A. Mackintosh, Craig A. Williams

Published in: Systematic Reviews | Issue 1/2021

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Abstract

Background

Cystic fibrosis (CF) is a genetically inherited, life-limiting condition, affecting ~90,000 people globally. Physical activity (PA) and exercise form an integral component of CF management, and have been highlighted by the CF community as an area of interest for future research. Previous reviews have solely focused on PA or structured exercise regimens independent of one another, and thus a comprehensive assessment of the physical health benefits of all PA, including exercise, interventions, is subsequently warranted. Therefore, the purpose of this review is to evaluate the effects of both PA and exercise upon outcomes of physical health and healthcare utilisation in people with CF.

Methods

A systematic review has been registered and reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P guidelines. This will include randomised control trials on the effects of PA and exercise, relative to usual treatment, upon people with CF. Primary outcomes will include variables associated with fitness, PA, lung health, inflammation, body composition, glycaemic control and patient-reported outcomes. Secondary outcomes will include adverse events and healthcare utilisation. Searches will be undertaken in Ovid MEDLINE, OVID EMBASE, PsychINFO, ERIC, SPORTDiscus, ASSIA, CCTR, CINHAL and Web of Science databases, and will be searched from date of inception onwards. Two reviewers will independently screen citations and abstracts, and full-texts, for inclusion and data extraction, respectively. Methodological quality will be assessed using the Cochrane Risk of Bias-2 tool. If feasible, random-effects meta-analyses will be conducted where appropriate. Additional analyses will explore potential sources of heterogeneity, such as age, sex, and disease severity.

Discussion

This systematic review will build on previous research, by comprehensively assessing the impact of both PA and exercise upon physical health and healthcare utilisation in people with CF. Results of this review will be utilised to inform discussions that will ultimately result in a consensus document on the impact of physical activity and exercise for people with CF.

Systematic review registration

PROSPERO CRD42020184411
Appendix
Available only for authorised users
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Metadata
Title
The impact of physical activity and exercise interventions for physical health in people with cystic fibrosis: protocol for a systematic review
Authors
Owen W. Tomlinson
Sarah Denford
Alan R. Barker
Jane E. Schneiderman
Emma S. Campisi
Helen Douglas
Sarah Rand
Melitta A. McNarry
Kelly A. Mackintosh
Craig A. Williams
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-021-01614-8

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