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01-12-2021 | Stroke | Protocol

Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials

Authors: Qing Zhao, Xue Wang, Tao Wang, Adam A. Dmytriw, Xiao Zhang, Kun Yang, Jichang Luo, Xuesong Bai, Nan Jiang, Bin Yang, Yan Ma, Liqun Jiao, Yunyan Xie

Published in: Systematic Reviews | Issue 1/2021

Abstract

Background

Stroke is the second leading cause of death worldwide, and 53.4% of stroke survivors suffer from post-stroke cognitive impairment. Post-stroke cognitive impairment can increase hospitalization rate and cost of care and decrease the quality of life of stroke patients. To date, multiple cognitive rehabilitation interventions have been tested in stroke populations with post-stroke cognitive impairment. However, the most efficacious intervention has not been established. This systematic review aims to compare the efficacy of cognitive rehabilitation interventions for patients with post-stroke cognitive impairment.

Methods

We will search MEDLINE, EMBASE, CENTRAL, PsycINFO, CINAHL, PubMed, and clinical trial registries to identify eligible randomized clinical trials with no restrictions in the date of publication and language. Studies conducted with patients aged 18 or over, with the presence of cognitive impairment after being diagnosed with stroke will be included. Studies will be restricted to randomized controlled trials comparing a cognitive rehabilitation intervention with another intervention. The primary outcome is any clinical changes in the general or specific cognitive domain (e.g., executive function, attention, memory, or perception). The secondary outcomes that will be collected include adverse effects (e.g., stroke, disability, or mortality) and quality of life. Two independent reviewers will assess articles to identify trials eligible for inclusion. Data extraction and risk of bias assessment of the included studies will also be done independently. Any discrepancies will be solved by discussion, or a third reviewer will be consulted if necessary. A meta-analysis will be carried out if appropriate.

Discussion

This systematic review for patients with post-stroke cognitive impairment will assess the efficacy of cognitive rehabilitation interventions. And our results will help clinical decision-making and support the development of clinical practice guidelines.

Trial registration

Systematic review registration: PROSPERO CRD42020173988

Available only for authorised users

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Title: Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials
Authors: Qing Zhao
Xue Wang
Tao Wang
Adam A. Dmytriw
Xiao Zhang
Kun Yang
Jichang Luo
Xuesong Bai
Nan Jiang
Bin Yang
Yan Ma
Liqun Jiao
Yunyan Xie
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Stroke
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-021-01607-7

At a glance: The STEP trials

Springer Medicine

Cognitive rehabilitation interventions after stroke: protocol for a systematic review and meta-analysis of randomized controlled trials

Abstract

Background

Methods

Discussion

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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