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Published in: Systematic Reviews 1/2021

Open Access 01-12-2021 | Gabapentin | Protocol

Gabapentin for phantom limb pain after amputation in pediatric oncology: a systematic review protocol

Authors: Shuang Jiang, Meng-meng Zhou, Rong Xia, Jing-hui Bai, Li-hui Yan

Published in: Systematic Reviews | Issue 1/2021

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Abstract

Background

Phantom limb pain (PLP) is a prevalent problem for children after amputation because of the chemotherapy treatment. Gabapentin is a potential option to manage PLP after amputation in pediatric oncology. However, no systematic review specifically investigated this topic. Thus, this study aims to appraise the efficacy and safety of gabapentin for post-amputation PLP in pediatric oncology.

Methods

Electronic databases (Cochrane Library, MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, Scopus, WANGFANG, and Chinese Biomedical Literature Database) will be systematically searched from the beginning to the present without limitations to publication status and language. Primary outcome is pain intensity. Secondary outcomes are analgesic drug consumption, sleep quality, depression, anxiety, health-related quality of life, and adverse events. The treatment effect of all dichotomous outcome data will be estimated as risk ratio and 95% confidence intervals (CIs) and that of continuous outcome data will be calculated as mean difference or standardized mean difference and 95% CIs. Methodological quality of randomized controlled trials (RCTs) will be assessed using Cochrane risk of bias tool and that of case-controlled studies (CCSs) will be appraised using Newcastle-Ottawa Tool. Statistical analysis will be conducted using RevMan 5.3 software.

Discussion

This study will summarize up-to-date high-quality RCTs and CCSs to assess the efficacy and safety of gabapentin for PLP after amputation in pediatric oncology. The findings of this study will help to determine whether or not gabapentin is effective and safe for children with PLP after amputation.

Systematic review registration

Appendix
Available only for authorised users
Literature
1.
2.
Probstner D, Thuler LC, Ishikawa NM, Alvarenga RM. Phantom limb phenomena in cancer amputees. Pain Pract. 2010;10(3):249–56.PubMedCrossRef
3.
Schley MT, Wilms P, Toepfner S, Schaller HP, Schmelz M, Konrad CJ, et al. Painful and nonpainful phantom and stump sensations in acute traumatic amputees. J Trauma. 2008;65(4):858–64.PubMed
4.
Ehde DM, Czerniecki JM, Smith DG, Campbell KM, Edwards WT, Jensen MP, et al. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000;81:1039–44.PubMedCrossRef
5.
Wilkins KL, McGrath PJ, Finley GA, Katz J. Phantom limb sensations and phantom limb pain in child and adolescent amputees. Pain. 1998;78:7–12.PubMedCrossRef
6.
Wilkins KL, McGrath PJ, Finley GA, Katz J. Prospective diary study of nonpainful and painful phantom sensations in a preselected sample of child and adolescent amputees reporting phantom limbs. Clin J Pain. 2004;20(5):293–301.PubMedCrossRef
7.
Smith J, Thompson JM. Phantom limb pain and chemotherapy in pediatric amputees. Mayo Clin Proc. 1995;70:357–64.PubMedCrossRef
8.
Thomas CR, Brazeal BA, Rosenberg L, Robert RS, Blakeney PE, Meyer WJ. Phantom limb pain in pediatric burn survivors. Burns. 2003;29:139–42.PubMedCrossRef
9.
Ephraim PL, Wegener ST, MacKenzie EJ, Dillingham TR, Pezzin LE. Phantom pain, residual limb pain, and back pain in amputees: results of a national survey. Arch Phys Med Rehabil. 2005;86(10):1910–9.PubMedCrossRef
10.
Poor Zamany Nejatkermany M, Modirian E, Soroush M, Masoumi M, Hosseini M. Phantom limb sensation (PLS) and phantom limb pain (PLP) among young landmine amputees. Iran J Child Neurol. 2016;10:42–7.PubMedPubMedCentral
11.
Richardson C, Glenn S, Nurmikko T, Horgan M. Incidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular disease. Clin J Pain. 2006;22(4):353–8.PubMedCrossRef
12.
13.
Burgoyne LL, Billups CA, Jirón JL Jr, Kaddoum RN, Wright BB, Bikhazi GB, et al. Phantom limb pain in young cancer-related amputees: recent experience at St Jude children's research hospital. Clin J Pain. 2012;28(3):222–5.PubMedPubMedCentralCrossRef
14.
Anghelescu DL, Kelly CN, Steen BD, Wu J, Wu H, DeFeo BM, et al. Mirror therapy for phantom limb pain at a pediatric oncology institution. Rehabil Oncol. 2016;34(3):104–10.PubMedPubMedCentralCrossRef
15.
van der Schans CP, Geertzen JH, Schoppen T, Dijkstra PU. Phantom pain and health-related quality of life in lower limb amputees. J Pain Symptom Manage. 2002;24:429–36.PubMedCrossRef
16.
Desmond DM, MacLachlan M. Prevalence and characteristics of phantom limb pain and residual limb pain in the long term after upper limb amputation. Int J Rehabil Res. 2010;33:279–82.PubMedCrossRef
17.
Arena JG, Sherman RA, Bruno GM, Smith JD. The relationship between situational stress and phantom limb pain: cross-lagged correlational data from six month pain logs. J Psychosom Res. 1990;34:71–7.PubMedCrossRef
18.
Han G, Bi WZ, Xu M, Jia JP, Wang Y. Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World J Surg. 2016;40(8):2016–27.PubMedCrossRef
19.
MacEwen EG, Kurzman ID. Canine osteosarcoma: amputation and chemoimmunotherapy. Vet Clin North Am Small Anim Pract. 1996;26(1):123–33.PubMedCrossRef
20.
Link M, Gebhardt M, Meyers P. Osteosarcoma. In: Pizzo PA, Poplack DG, editors. Principles and practices of pediatric oncology. Philadelphia: Lippincott Williams &Wilkins; 2006. p. 1074–115.
21.
Wu CL, Agarwal S, Tella PK, et al. Morphine versus mexiletine for treatment of postamputation pain: a randomized, placebo-controlled, crossover trial. Anesthesiology. 2008;109:289–96.PubMedCrossRef
22.
23.
Andrews CO, Fischer JH. Gabapentin: a new agent for the management of epilepsy. Ann Pharmacother. 1994;28(10):1188–96.PubMedCrossRef
24.
Goa KL, Sorkin EM. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993;46(3):409–27.PubMedCrossRef
25.
Rosenberg JM, Harrell C, Ristic H, Werner RA, deRosayro M. The effect of gabapentin on neuropathic pain. Clin J Pain. 1997;13:251–5.PubMedCrossRef
26.
Samineni VK, Premkumar LS, Faingold CL. Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin. Pain. 2017;158(7):1241–53.PubMedPubMedCentralCrossRef
27.
Rimaz S, Alavi CE, Sedighinejad A, Tolouie M, Kavoosi S, Koochakinejad L. Effect of gabapentin on morphine consumption and pain after surgical debridement of burn wounds: a double-blind randomized clinical trial study. Arch Trauma Res. 2012;1(1):38–43.PubMedPubMedCentralCrossRef
28.
Abbass K. Efficacy of gabapentin for treatment of adults with phantom limb pain. Ann Pharmacother. 2012;46(12):1707–11.PubMedCrossRef
29.
Doleman B, Heinink TP, Read DJ, et al. A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia. 2015;70:1186–204.PubMedCrossRef
30.
Rusy LM, Troshynski TJ, Weisman SJ. Gabapentin in phantom limb pain management in children and young adults: report of seven cases. J Pain Symptom Manage. 2001;21(1):78–82.PubMedCrossRef
31.
Bone M, Critchley P, Buggy DJ. Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study. Reg Anesth Pain Med. 2002;27(5):481–6.PubMed
32.
Wang X, Yi Y, Tang D, Chen Y, Jiang Y, Peng J, et al. Gabapentin as an adjuvant therapy for prevention of acute phantom-limb pain in pediatric patients undergoing amputation for malignant bone tumors: a prospective double-blind randomized controlled trial. J Pain Symptom Manage. 2018;55(3):721–7.PubMedCrossRef
33.
Kendall MC, Castro-Alves LJ. Gabapentin to prevent acute phantom-limb pain in pediatric patients undergoing amputation. J Pain Symptom Manage. 2018;56(2):e4.PubMedCrossRef
34.
Shamseer L, Moher D, Clarke M, et al. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;349:g7647.CrossRef
35.
Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.PubMedPubMedCentralCrossRef
36.
37.
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.CrossRefPubMed
38.
39.
40.
41.
Page MJ, Altman DG, McKenzie JE, Shamseer L, Ahmadzai N, Wolfe D, et al. Flaws in the application and interpretation of statistical analyses in systematic reviews of therapeutic interventions were common: a cross-sectional analysis. J Clin Epidemiol. 2018;95:7–18.PubMedCrossRef
42.
Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6.PubMedPubMedCentralCrossRef
43.
Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490.PubMedCrossRef
Metadata
Title
Gabapentin for phantom limb pain after amputation in pediatric oncology: a systematic review protocol
Authors
Shuang Jiang
Meng-meng Zhou
Rong Xia
Jing-hui Bai
Li-hui Yan
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Gabapentin
Published in
Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-020-01571-8

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