Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Systematic Reviews
Published in: Systematic Reviews 1/2019

Open Access 01-12-2019 | Protocol

Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies

Authors: Kevin T. Chorath, Matthew J. Willis, Nicolas Morton-Gonzaba, Walter J. Humann, Alvaro Moreira

Published in: Systematic Reviews | Issue 1/2019

Login to get access

Abstract

Background

Sensorineural hearing loss (SNHL) is the most common form of hearing impairment and is characterized by a loss of receptor hair cells and/or spiral ganglion neurons. Regenerative stem cell therapy could potentially restore normal hearing and slow the progression of hearing loss in patients. Preclinical animal studies have demonstrated that mesenchymal stem cells (MSCs) could be a promising new therapy for this condition. These findings have prompted investigators to begin human clinical trials to assess the safety and efficacy of MSCs for the treatment of SNHL. The objective of the proposed systematic review is to examine the efficacy of MSCs as a therapy for SNHL in animal models.

Methods

We will include preclinical animal studies of SNHL in which MSCs are administered, and outcomes are compared against MSC-naïve controls. The primary outcome will include audiologic tests that are routinely used in experimental studies of hearing loss, such as auditory brainstem response (ABR) and distortion product otoacoustic emissions testing (DPOAE). Secondary outcomes will include histology, microscopy, gene protein expression, and behavioral responses of animals. Electronic searches of MEDLINE via PubMed, Scopus, ScienceDirect, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) will be performed. Search results will be screened independently and in duplicate. Data from eligible studies will be extracted, pooled, and analyzed using random effects models. Risk of bias and publication bias will be assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) risk of bias tool and Funnel Plots/Egger’s regression tests, respectively.

Discussion

This systematic review will provide a summary of the efficacy of MSC therapy in animal models of SNHL, utilizing functional hearing assessment as a primary outcome. Findings from this review are important because they can elucidate research gaps that should be addressed in future preclinical studies and in turn can be translated into clinical studies.

Systematic review registration

Appendix
Available only for authorised users
Literature
1.
Summary of 2009 National CDC EHDI Data Source: 2009 CDC EHDI Hearing Screening & Follow-up Survey (HSFS) Number of Respondents: 50 (47 states and 3 territories) 2009 Documented EHDI Data Items Summary of 2009 National CDC EHDI Data. 2012;50(January):50–3.
2.
Ma Y, Guo W, Yi H, Ren L, Zhao L, Zhang Y, et al. Transplantation of human umbilical cord mesenchymal stem cells in cochlea to repair sensorineural hearing. Am J Transl Res. 2016;8(12):5235–45.PubMedPubMedCentral
3.
Yoshinaga-Itano C, Sedey A, Coulter D, Mehl A. Language of early-and later-identified children with hearing loss. Pediatrics. 1998;102(5):1161–71.CrossRef
4.
Allen TE. Patterns of academic achievement among hearing impaired students: 1974 and 1983. In: Schildroth AN, Karchmer MA, eds. Deaf children in America. Boston, MA: College-Hill press; 1986:161–206.
5.
Youm I, Li W. Cochlear hair cell regeneration: an emerging opportunity to cure noise- induced sensorineural hearing loss. Drug Discov Today [Internet] Elsevier Ltd; 2018;00(00):1–6.
6.
Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep [Internet] 2015;35(2):1–18.CrossRef
7.
Cárdenes N, Cáceres E, Romagnoli M, Rojas M. Mesenchymal stem cells: a promising therapy for the acute respiratory distress syndrome. Respiration. 2013;85(4):267–78.CrossRef
8.
Karantalis V, Hare JM. Use of mesenchymal stem cells for therapy of cardiac disease. Circ Res. 2015;116(8):1413–30.CrossRef
9.
Figueroa FE, Carrión F, Villanueva S, Khoury M. Mesenchymal stem cell treatment for autoimmune diseases: a critical review. Biol Res. 2012;45(3):269–77.CrossRef
10.
Eom YW, Shim KY, Baik SK. Mesenchymal stem cell therapy for liver fibrosis. Korean J Intern Med [Internet] 2015;30(5):580–589.CrossRef
11.
Lee HS, Kim WJ, Gong JS, Park KH. Clinical safety and efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation in sensorineural hearing loss patients. J Audiol Otol. 2018;22(2):105–9.CrossRef
12.
Bas E, Van De WTR, Goss G, Hare JM, Goldstein BJ. Adult human nasal mesenchymal-like stem cells. Stem Cells Dev. 2014;23(5):502–14.CrossRef
13.
14.
Hooijmans C, Rovers M, de Vries R, Leenaars M, Ritskes-Hoitinga M, Langendam M. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14(1):43.CrossRef
15.
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 2006;8:315–7.CrossRef
16.
Reis A. Animal models for hearing evaluations : a literature review Modelos animais Para avaliação auditiva: revisão de literatura. Rev. CEFAC. 2017;19(3):417–27.CrossRef
17.
Hooijmans CR, Rovers MM, De Vries RBM, Leenaars M, Ritskes-hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014:1–9.
18.
Henderson VC, Kimmelman J, Fergusson D, Grimshaw JM, Hackam DG. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med. 2013;10(7):e1001489.CrossRef
19.
Friedrich JO, Adhikari NKJ, Beyene J. The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study. BMC Med Res Methodol. 2008;15:32.CrossRef
20.
Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;1558:1539–58.CrossRef
21.
Hayashino Y, Noguchi Y, Fukui T. Systematic evaluation and comparison of statistical tests for publication bias. J Epidemiol. 2005;15:235–43.CrossRef
22.
Liu H, Qu Z, Sun S, Xiao D, Yang T, Chen L, Wang Y. Intravenous injection of human umbilical cord derived mesenchymal stem cells for the treatment of sudden sensorineural hearing loss: a case report. Paper presented at the WIT Transactions on Biomedicine and Health. 2014;19:485–92.CrossRef
Metadata
Title
Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies
Authors
Kevin T. Chorath
Matthew J. Willis
Nicolas Morton-Gonzaba
Walter J. Humann
Alvaro Moreira
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2019
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-019-1015-7

Other articles of this Issue 1/2019

Systematic Reviews 1/2019 Go to the issue

Protocol

Prevalence of type 2 diabetes mellitus among hepatitis C virus-infected patients: a protocol for systematic review and meta-analysis

Correction

Correction to: Integrated models of care for diabetes and hypertension in low- and middle-income countries (LMICs): Protocol for a systematic review

Protocol

Feasibility, acceptability, and effectiveness of young people-specific, integrated out-of-hospital services: a protocol for a systematic review

Protocol

Inappropriateness of health care in Canada: a systematic review protocol

Systematic review update

Evidence of past dental visits and incidence of head and neck cancers: a systematic review and meta-analysis

Protocol

Risk factors for hearing loss in children: a systematic literature review and meta-analysis protocol