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Systematic Reviews
Published in: Systematic Reviews 1/2018

Open Access 01-12-2018 | Protocol

Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review

Authors: Eldré W. Beukes, Vinaya Manchaiah, David M. Baguley, Peter M. Allen, Gerhard Andersson

Published in: Systematic Reviews | Issue 1/2018

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Abstract

Background

Internet-based interventions are emerging as an alternative way of delivering accessible healthcare for various conditions including hearing and balance disorders. A comprehensive review regarding the evidence-base of Internet-based interventions for auditory-related conditions is required to determine the existing evidence of their efficacy and effectiveness. The objective of the current protocol is to provide the methodology for a systematic review regarding the effects of Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders.

Method

This protocol was developed according to the Preferred Reporting Items for Systematic reviews and Meta-analyses for Protocols (PRISMA-P) 2015 guidelines. Electronic database searches will include EBSCOhost, PubMed and Cochrane Central Register performed by two researchers. This will be complemented by searching other resources such as the reference lists for included studies to identify studies meeting the eligibility for inclusion with regard to study designs, participants, interventions, comparators and outcomes. The Cochrane risk of bias tool (RoB 2) for randomised trials will be used for the bias assessments in the included studies. Criteria for conducting meta-analyses were defined.

Discussion

The result of this systematic review will be of value to establish the effects of Internet-based interventions for hearing loss, tinnitus and vestibular disorders. This will be of importance to guide future planning of auditory intervention research and clinical services by healthcare providers, researchers, consumers and stakeholders.

Systematic review registration

Appendix
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Literature
1.
Miura M, Goto F, Inagaki Y, Nomura Y, Oshima T, Sugaya N. The effect of comorbidity between tinnitus and dizziness on perceived handicap, psychological distress, and quality of life. Front Neurol. 2017;8:722.
2.
Nordvik Ø, Heggdal POL, Brännström J, Vassbotn F, Aarstad AK, Aarstad HJ. Generic quality of life in persons with hearing loss: a systematic literature review. BMC Ear, Nose and Throat Disorders. 2018;18(1):1.CrossRef
3.
4.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA. Association of age-related hearing loss with cognitive function, cognitive impairment, and dementia: a systematic review and meta-analysis. JAMA Otolaryngology–Head & Neck Surgery. 2017.
5.
Gonzales SC, Proctor D, Mandavia R, Evans H, Goman AM, Lin FR, et al. Hearing loss and risk of incident cognitive impairment and dementia: a meta-analysis of cohort studies. Alzheimers Dement. 2017;13(7):P1422.CrossRef
6.
Hall DA, Fackrell K, Li AB, Thavayogan R, Smith S, Kennedy V, et al. A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others. Health Qual Life Outcomes. 2018;16(1):61.PubMedPubMedCentralCrossRef
7.
Langguth B. A review of tinnitus symptoms beyond ‘ringing in the ears’: a call to action. Curr Med Res Opin. 2011;27(8):1635–43.PubMedCrossRef
8.
Agrawal Y, Pineault KG, Semenov YR. Health-related quality of life and economic burden of vestibular loss in older adults. Laryngoscope Investigative Otolaryngology. 2018;3(1):8–15.PubMedCrossRef
9.
Benecke H, Agus S, Goodall G, Kuessner D, Strupp M. The burden and impact of vertigo: findings from the REVERT patient registry. Front Neurol. 2013;4:136.PubMedPubMedCentralCrossRef
10.
11.
Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1545–602.CrossRef
12.
Gallus S, Lugo A, Garavello W, Bosetti C, Santoro E, Colombo P, et al. Prevalence and determinants of tinnitus in the Italian adult population. Neuroepidemiology. 2015;45(1):12–9.PubMedCrossRef
13.
Kim H, Lee H, An S, Sim S, Park B, Kim SW, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015;10(5):e0127578.PubMedPubMedCentralCrossRef
14.
Wu B, Searchfield G, Exeter D, Lee A. Tinnitus prevalence in New Zealand. N Z Med J. 2015;128(1423):6683.
15.
Dawes P, Fortnum H, Moore DR, Emsley R, Norman P, Cruickshanks K, et al. Hearing in middle age: a population snapshot of 40- to 69-year olds in the United Kingdom. Ear Hear. 2014 May-Jun;35(3):e44–51.PubMedPubMedCentralCrossRef
16.
Davis A, Rafaie EA. Epidemiology of tinnitus. In: Tyler RS, editor. Tinnitus Handbook. San Diego, CA: Singular, Thomson Learning; 2000. p. 1–23.
17.
Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med. 2010;123(8):711–8.PubMedCrossRef
18.
Bhatt JM, Lin HW, Bhattacharyya N. Prevalence, severity, exposures, and treatment patterns of tinnitus in the United States. JAMA Otolaryngology–Head & Neck Surgery. 2016;142(10):959–65.CrossRef
19.
Agrawal Y, Carey JP, Della Santina CC, Schubert MC, Minor LB. Disorders of balance and vestibular function in US adults: data from the National Health and nutrition examination survey, 2001-2004. Arch Intern Med. 2009;169(10):938–44.PubMedCrossRef
20.
Baguley D, Andersson G, McKenna L. Tinnitus, a multidisciplinary approach. 2nd ed. Wiley-Blackwell: Chichester; 2013.CrossRef
21.
McCormack A, Edmondson-Jones M, Somerset S, Hall D. A systematic review of the reporting of tinnitus prevalence and severity. Hear Res. 2016;337:70–9.PubMedCrossRef
22.
Jönsson R, Sixt E, Landahl S, Rosenhall U. Prevalence of dizziness and vertigo in an urban elderly population. J Vestib Res. 2004;14(1):47–52.PubMed
23.
Bainbridge KE, Wallhagen MI. Hearing loss in an aging American population: extent, impact, and management. Annu Rev Public Health. 2014;35:139–52.PubMedCrossRef
24.
World Health Organization. World report on ageing and health. World Health Organization; 2015. Geneva: WHO. ISBN: 9789241565042.
25.
26.
Stockdale D, McFerran D, Brazier P, Pritchard C, Kay T, Dowrick C, et al. An economic evaluation of the healthcare cost of tinnitus management in the UK. BMC Health Serv Res. 2017;17(1):577.PubMedPubMedCentralCrossRef
27.
Sun DQ, Ward BK, Semenov YR, Carey JP, Della Santina CC. Bilateral vestibular deficiency: quality of life and economic implications. JAMA Otolaryngology–Head & Neck Surgery. 2014;140(6):527–34.CrossRef
28.
Cima R, Joore M, Maes I, Scheyen D, Refaie AE, Baguley DM, et al. Cost-effectiveness of multidisciplinary management of Tinnitus at a specialized Tinnitus centre. BMC Health Serv Res. 2009;9:29–6963–9-29.
29.
Yardley L, Barker F, Muller I, Turner D, Kirby S, Mullee M, et al. Clinical and cost effectiveness of booklet based vestibular rehabilitation for chronic dizziness in primary care: single blind, parallel group, pragmatic, randomised controlled trial. Br Med J. 2012 Jun 6;344:e2237.CrossRef
30.
Vuorialho A, Karinen P, Sorri M. Counselling of hearing aid users is highly cost-effective. European Archives of Oto-Rhino-Laryngology and Head & Neck. 2006;263(11):988–95.CrossRef
31.
Porciuncula F, Johnson CC, Glickman LB. The effect of vestibular rehabilitation on adults with bilateral vestibular hypofunction: a systematic review. Journal of Vestibular Research. 2012;22(5,6):283–98.PubMed
32.
Hesser H, Weise C, Westin VZ, Andersson G. A systematic review and meta-analysis of randomized controlled trials of cognitive–behavioral therapy for tinnitus distress. Clin Psychol Rev. 2011;31(4):545–53.PubMedCrossRef
33.
Chisolm TH, Johnson CE, Danhauer JL, Portz LJ, Abrams HB, Lesner S, et al. A systematic review of health-related quality of life and hearing aids: final report of the American Academy of Audiology task force on the health-related quality of life benefits of amplification in adults. J Am Acad Audiol. 2007;18(2):151–83.PubMedCrossRef
34.
Pronk M, Kramer SE, Davis AC, Stephens D, Smith PA, Thodi C, et al. Interventions following hearing screening in adults: a systematic descriptive review. Int J Audiol. 2011;50(9):594–609.PubMedCrossRef
35.
Barnett M, Hixon B, Okwiri N, Irungu C, Ayugi J, Thompson R, et al. Factors involved in access and utilization of adult hearing healthcare: a systematic review. Laryngoscope. 2017;127(5):1187–94.PubMedCrossRef
36.
McDonnell MN, Hillier SL. Vestibular rehabilitation for unilateral peripheral vestibular dysfunction. Cochrane Database Syst Rev. 2015;1:CD005397.
37.
Yardley L, Donovan-Hall M, Smith HE, Walsh BM, Mullee M, Bronstein AM. Effectiveness of primary care–based vestibular rehabilitation for chronic dizziness. Ann Intern Med. 2004;141(8):598–605.PubMedCrossRef
38.
Hoare DJ, Broomhead E, Stockdale D, Kennedy V. Equity and person-centeredness in provision of tinnitus services in UK National Health Service audiology departments. Eur J Pers Cent Healthc. 2015;3(3):318–26.CrossRef
39.
Beukes EW, Vlaescu G, Manchaiah V, Baguley DM, Allen PM, Kaldo V, et al. Development and technical functionality of an internet-based intervention for tinnitus in the UK. Internet Interv. 2016;6:6–15.PubMedPubMedCentralCrossRef
40.
Thorén E, Svensson M, Törnqvist A, Carlbring P, Lunner T. Rehabilitative online education versus internet discussion group for hearing aid users: a randomized controlled trial. J Am Acad Audiol. 2011;22(5):274–85.PubMedCrossRef
41.
Pyykkő I, Manchaiah V, Kentala E, Levo H, Juhola M. Internet-based self-help for Ménière’s disease: details and outcome of a single-group open trial. Am J Audiol. 2017;26(4):496–506.PubMedCrossRef
42.
Andersson G, Stromgren T, Strom L, Lyttkens L. Randomized controlled trial of internet-based cognitive behavior therapy for distress associated with tinnitus. Psychosom Med. 2002 Sep-Oct;64(5):810–6.PubMed
43.
Thorén ES, Öberg M, Wänström G, Andersson G, Lunner T. A randomized controlled trial evaluating the effects of online rehabilitative intervention for adult hearing-aid users. Int J Audiol. 2014;53(7):452–61.PubMedCrossRef
44.
Andersson G, Kaldo V. Internet-based cognitive behavioral therapy for tinnitus. J Clin Psychol. 2004;60(2):171–8.PubMedCrossRef
45.
Geraghty AWA, Essery R, Kirby S, Stuart B, Turner D, Little P, et al. Internet-based vestibular rehabilitation for older adults with chronic dizziness: a randomized controlled trial in primary care. Annuals of Family Medicine. 2017 May;15(3):209–16.CrossRef
46.
Henshaw H, Ferguson MA. Efficacy of individual computer-based auditory training for people with hearing loss: a systematic review of the evidence. PLoS One. 2013;8(5):e62836.PubMedPubMedCentralCrossRef
47.
Hesser H, Gustafsson T, Lundén C, Henrikson O, Fattahi K, Johnsson E, et al. A randomized controlled trial of internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatment of tinnitus. J Consult Clin Psychol. 2012;80(4):649.PubMedCrossRef
48.
Hoare DJ, Kowalkowski VL, Kang S, Hall DA. Systematic review and meta-analyses of randomized controlled trials examining tinnitus management. Laryngoscope. 2011;121(7):1555–64.PubMedPubMedCentralCrossRef
49.
Nyenhuis N, Golm D, Kröner-Herwig B. A systematic review and meta-analysis on the efficacy of self-help interventions in tinnitus. Cogn Behav Ther. 2013;42(2):159–69.PubMedCrossRef
50.
Ricci NA, Aratani MC, Doná F, Macedo C, Caovilla HH, Ganança FF. A systematic review about the effects of the vestibular rehabilitation in middle-age and older adults. Brazilian Journal of Physical Therapy. 2010;14(5):361–71.PubMedCrossRef
51.
Andersson G, Cuijpers P, Carlbring P, Riper H, Hedman E. Guided internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: a systematic review and meta-analysis. World Psychiatry. 2014;13(3):288–95.PubMedPubMedCentralCrossRef
52.
Green S, Higgins J. Glossary.Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005] 2009.
53.
O'Connor D, Green S, Higgins JP. Defining the review question and developing criteria for including studies. Cochrane handbook for systematic reviews of interventions. 2008:81–94.
54.
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Br Med J. 2015;350:g7647.CrossRef
55.
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic reviews. 2015;4(1):1.PubMedPubMedCentralCrossRef
56.
Dissemination systematic reviews: CRD’s Guidance for Undertaking Reviews in Health Care. Layerthorpe: University of York, Centre for Reviews and Dissemination; 2009. 978–1–900640-47-3.
57.
McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS peer review of electronic search strategies: 2015 guideline statement. J Clin Epidemiol. 2016;75:40–6.PubMedCrossRef
58.
Rethlefsen ML, Farrell AM, Trzasko LCO, Brigham TJ. Librarian co-authors correlated with higher quality reported search strategies in general internal medicine systematic reviews. J Clin Epidemiol. 2015;68(6):617–26.PubMedCrossRef
59.
Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC medical informatics and decision making. 2007;7(1):16.PubMedPubMedCentralCrossRef
60.
Cordoba G, Schwartz L, Woloshin S, Bae H, Gotzsche PC. Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review. Br Med J. 2010 Aug 18;341:c3920.CrossRef
61.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.PubMedCrossRef
62.
Lovibond PF, Lovibond SH. The structure of negative emotional states: comparison of the depression anxiety stress scales (DASS) with the Beck depression and anxiety inventories. Behaviour Research Therapy. 1995;33(3):335–43.PubMedCrossRef
63.
Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of International Medicine. 2006;166(10):1092–7.CrossRef
64.
Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. Journal of Consultant Clinical Psychology. 1988;56(6):893.CrossRef
65.
Löwe B, Kroenke K, Herzog W, Gräfe K. Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9). Journal of Affective Disorders. 2004;81(1):61–6.PubMedCrossRef
66.
Beck AT, Steer RA, Brown GK. Beck depression inventory-II. San Antonio. 1996;78(2):490–8.
67.
Bastien CH, Vallières A, Morin CM. Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297–307.PubMedCrossRef
68.
Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. Journal of Personality Assessment 1985 02/01; 2014;49(1):71–75.PubMedCrossRef
69.
Frisch MB, Cornell J, Villanueva M, Retzlaff PJ. Clinical validation of the Quality of Life Inventory. A measure of life satisfaction for use in treatment planning and outcome assessment. Psychological Assessment. 1992;4(1):92.CrossRef
70.
Whoqol Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med. 1998;28(3):551–8.CrossRef
71.
Higgins JPT, Sterne JAC, Savović J, Page MJ, Hróbjartsson A, Boutron I, Reeves B, Eldridge S. A revised tool for assessing risk of bias in randomized trials In: Chandler J, McKenzie J, Boutron I, Welch V (editors). Cochrane Methods. Cochrane Database of Systematic Reviews 2016, Issue 10 (Suppl 1). dx.doi.org/https://​doi.​org/​10.​1002/​14651858.​CD201601.
72.
Borenstein M, Rothstein D, Cohen J. Comprehensive meta-analysis: a computer program for research synthesis [computer software]. Biostat: Englewood; 2005.
73.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315(7109):629–34.CrossRef
74.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 23: independent subgroups within a study. In introduction to meta-analysis. Edited by Borenstein M, hedges LV, Higgins JPT, Rothstein HR. Chichester: John Wiley & Sons; 2009a.
75.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 24: multiple comparisons within a study. In: Borenstein M, Hedges LV, JPT H, Rothstein HR, editors. introduction to meta-analysis. Chichester: John Wiley & Sons; 2009b.CrossRef
76.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 25: multiple outcomes or time-points within a study. In: Borenstein M, Hedges LV, JPT H, Rothstein HR, editors. introduction to meta-analysis. Chichester: John Wiley & Sons; 2009c.CrossRef
77.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 26: notes on complex data structures. In: Borenstein M, Hedges LV, JPT H, Rothstein HR, editors. introduction to meta-analysis. Chichester: John Wiley & Sons; 2009d.CrossRef
78.
Higgins JPT, Deeks JJ, Altman DG (editors). Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. [online] Available from:https://​handbook-5-1.​cochrane.​org/​. (Accessed 30 October 2018).
79.
Shuster JJ. Cochrane handbook for systematic reviews for interventions, version 5.1. 0, published 3/2011. Julian PT Higgins and Sally Green, editors. Res Synth Methods 2011;2(2):126–130.
80.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. In: Borenstein M, Hedges LV, JPT H, Rothstein HR, editors. Chapter 41: reporting the results of a meta-analysis. Chichester: John Wiley & Sons; 2009e.
81.
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Br Med J. 2003;327(7414):557–60.CrossRef
82.
Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Chapter 29: power analysis for meta-analysis. In: Borenstein M, Hedges LV, JPT H, Rothstein HR, editors. introduction to meta-analysis. Chichester: John Wiley & Sons; 2009f.CrossRef
83.
Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401–6.PubMedCrossRef
84.
Donahue A, Dubno JR, Beck L. Guest editorial: accessible and affordable hearing health care for adults with mild to moderate hearing loss. Ear Hear. 2010;31(1):2–6.PubMedPubMedCentralCrossRef
85.
Newman CW, Weinstein BE, Jacobson GP, Hug GA. The hearing handicap inventory for adults: psychometric adequacy and audiometric correlates. Ear Hear. 1990;11(6):430–3.PubMedCrossRef
86.
87.
Newman CW, Jacobson GP, Spitzer JB. Development of the tinnitus handicap inventory. Archives of Otolaryngology–Head & Neck Surgery. 1996;122(2):143–8.CrossRef
88.
Goebel G, Hiller W. The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire. HNO. 1994 Mar;42(3):166–72.PubMed
89.
90.
Meikle MB, Henry JA, Griest SE, Stewart BJ, Abrams HB, McArdle R, et al. The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus. Ear Hear. 2012;33(2):153–76.PubMedCrossRef
91.
Kuk FK, Tyler RS, Russell D, Jordan H. The psychometric properties of a tinnitus handicap questionnaire. Ear Hear. 1990;11(6):434–45.PubMedCrossRef
92.
Wilhelmsen K, Strand LI, Nordahl SHG, Eide GE, Ljunggren AE. Psychometric properties of the Vertigo symptom scale–Short form. BMC Ear, Nose and Throat Disorders. 2008;8(1):2.CrossRef
93.
Morris AE, Lutman ME, Yardley L. Measuring outcome from vestibular rehabilitation, part II: refinement and validation of a new self-report measure. Int J Audiol. 2009;48(1):24–37.PubMedCrossRef
94.
Jacobson GP, Newman CW. The development of the dizziness handicap inventory. Archives of Otolaryngology–Head & Neck Surgery. 1990;116(4):424–7.CrossRef
95.
Yardley L, Putman J. Quantitative analysis of factors contributing to handicap and distress in vertiginous patients: a questionnaire study. Clin Otolaryngol Allied Sci. 1992;17(3):231–6.PubMedCrossRef
Metadata
Title
Internet-based interventions for adults with hearing loss, tinnitus and vestibular disorders: a protocol for a systematic review
Authors
Eldré W. Beukes
Vinaya Manchaiah
David M. Baguley
Peter M. Allen
Gerhard Andersson
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2018
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-018-0880-9

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