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Systematic Reviews
Published in: Systematic Reviews 1/2018

Open Access 01-12-2018 | Research

Deworming in non-pregnant adolescent girls and adult women: a systematic review and meta-analysis

Authors: Elizabeth Tanjong Ghogomu, Shalini Suresh, Pura Rayco-Solon, Alomgir Hossain, Jessie McGowan, Juan Pablo Peña-Rosas, Vivian Welch

Published in: Systematic Reviews | Issue 1/2018

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Abstract

Background

The impact of deworming on parasite load, nutritional status and other health outcomes of non-pregnant adolescent girls and adult women is uncertain.

Methods

MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials, the WHO International Clinical Trials Registry Platform, the Cochrane Database of Systematic Reviews and Food and Technology Abstracts databases were searched until 24 September 2018. Studies were included if they were randomised controlled trials (RCTs), controlled before and after studies or interrupted time studies comparing deworming with no intervention or placebo in non-pregnant adolescent girls and women 10 to 49 years old. Outcomes of interest included parasite load, reinfection, anaemia, severe anaemia, iron deficiency, diarrhoea or all-cause morbidity. Risk of bias was assessed using the Cochrane risk of bias tool.

Results

We included four RCTs of mass deworming involving 1086 participants, in the analyses. Mass deworming probably reduces the prevalence of roundworm infection (RR 0.29; 95% CI 0.14 to 0.62; 2 trials; 1498 participants, moderate certainty evidence), prevalence of hookworm infection (RR 0.32; 95% CI 0.18 to 0.59; 2 trials; 1498 participants, moderate certainty evidence), prevalence of whipworm infection (RR 0.77; 95% CI 0.65 to 0.91; 2 trials; 1498 participants, moderate certainty evidence) compared to the control group. Deworming may make little or no difference in prevalence of anaemia (RR 0.82; 95% CI 0.60 to 1.11, 3 studies, 683 participants, low certainty evidence) and prevalence of iron-deficiency (RR 0.89; 95% CI 0.64 to 1.23, 1 study, 186 participants, low certainty evidence) compared to control. We are uncertain whether deworming reduces the prevalence of severe anaemia compared to control as the certainty of evidence was very low. None of the included studies assessed screen and treat deworming or reported reinfection, diarrhoea or adverse events.

Conclusions

Mass deworming probably reduces the prevalence of soil-transmitted helminth infections but may have little or no effect on anaemia and iron-deficiency in adolescent girls and non-pregnant women in comparison to no intervention or placebo. We are uncertain about the effect on severe anaemia. These results are limited by sparse data and the moderate to very low quality of evidence available.

Systematic review registration

The protocol was registered in PROSPERO (registration number: CRD42016039557). 
Primary source of funding: Evidence and Programme Guidance unit, Department of Nutrition for Health and Development, World Health Organization (WHO).
Appendix
Available only for authorised users
Footnotes
1
Soil-transmitted helminth prevalence is defined as the percentage of population that have one or more soil transmitted helminth infections.
 
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Metadata
Title
Deworming in non-pregnant adolescent girls and adult women: a systematic review and meta-analysis
Authors
Elizabeth Tanjong Ghogomu
Shalini Suresh
Pura Rayco-Solon
Alomgir Hossain
Jessie McGowan
Juan Pablo Peña-Rosas
Vivian Welch
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2018
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-018-0859-6

Other articles of this Issue 1/2018

Systematic Reviews 1/2018 Go to the issue

Protocol

The HEART score in predicting major adverse cardiac events in patients presenting to the emergency department with possible acute coronary syndrome: protocol for a systematic review and meta-analysis

Systematic review update

Behavioral and cognitive interventions to improve treatment adherence and access to HIV care among older adults in sub-Saharan Africa: an updated systematic review

Protocol

Bioactive scaffolds in stem-cell-based therapies for cardiac repair: protocol for a meta-analysis of randomized controlled preclinical trials in animal myocardial infarction models

Research

Anesthesia interventions that alter perioperative mortality: a scoping review

Protocol

T cell activation and cardiovascular risk in type 2 diabetes mellitus: a protocol for a systematic review and meta-analysis

Research

The use of clinical study reports to enhance the quality of systematic reviews: a survey of systematic review authors