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Open Access 01-12-2018 | Protocol

Indicators of deterioration in young adults with serious mental illness: a systematic review protocol

Authors: Lindsay H. Dewa, Elizabeth Cecil, Lynne Eastwood, Ara Darzi, Paul Aylin

Published in: Systematic Reviews | Issue 1/2018

Abstract

Background

The first signs of serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression are likely to occur before the age of 25. The combination of high prevalence of severe mental health symptoms, inability to recognise mental health deterioration and increased likelihood of comorbidity in a complex transitional young group makes detecting deterioration paramount. Whilst studies have examined physical and mental health deterioration in adults, no systematic review has examined the indicators of mental and physical deterioration in young adults with SMI. The study aim is to systematically review the existing evidence from observational studies that examine the indicators of mental and physical deterioration in young adults with SMI and highlight gaps in knowledge to inform future research.

Methods

Seven databases including CINHAL, MEDLINE, Embase, PsycINFO, Health Management Information Consortium, Cochrane databases and Web of Science will be searched against five main facets (age, serious mental illness, sign, deterioration and patient) and a subsequent comprehensive list of search terms. Searches will be run individually in each database to reflect each unique set of relevant subject headings and appropriate MeSH terms. Inclusion and exclusion criteria were developed and refined by the research team. Two reviewers will participate in each search stage including abstract/title and full text screening, data extraction and appraisal, to ensure reliability. A narrative synthesis of the data will also be conducted.

Discussion

This systematic review will likely make a significant contribution to the field of mental health and help inform future research pertaining to interventions that help highlight deteriorating patients. This may vary depending on the patient group, mental illness or deterioration type.

Systematic review registration

PROSPERO CRD42017075755

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Title: Indicators of deterioration in young adults with serious mental illness: a systematic review protocol
Authors: Lindsay H. Dewa
Elizabeth Cecil
Lynne Eastwood
Ara Darzi
Paul Aylin
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Systematic Reviews / Issue 1/2018
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-018-0781-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Indicators of deterioration in young adults with serious mental illness: a systematic review protocol

Abstract

Background

Methods

Discussion

Systematic review registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Discussion

Systematic review registration

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