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Systematic Reviews
Published in: Systematic Reviews 1/2017

Open Access 01-12-2017 | Protocol

Protocol: systematic review of the association between socio-economic status and survival in adult head and neck cancer

Authors: Bilal G. Taib, Joseph Rylands, Sue Povall, Terry M. Jones, David Taylor-Robinson

Published in: Systematic Reviews | Issue 1/2017

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Abstract

Background

Head and neck cancer incidence is increasing worldwide. Despite overall improvements in survival, numerous studies suggest worse survival in more disadvantaged populations; however, this literature has not been systematically reviewed. The aim of this review is to investigate whether lower compared to higher socioeconomic status (SES) influences survival in head and neck squamous cell cancer (HNSCC) and explore possible explanations for any relationship found.

Method

A systematic strategy will be used to identify articles, appraise their quality and extract data. Online databases including MEDLINE, Web of Knowledge, ESBCO Host and Scopus will be used to locate observational studies of adults with a primary diagnosis of head and neck cancer in EU15+ countries (15 members of the EU, Australia, Canada, Norway, USA and New Zealand) where the outcomes report associations between SES and survival. This will be augmented by searching for grey literature and through reference lists. Data will be extracted using a standardised form. Study quality will be assessed using the Newcastle Ottawa scale and where possible meta-analysis of the pooled data will be conducted.

Discussion

This review will quantify the association between SES and survival outcomes for adult head and neck cancer patients in developed countries. The results will help identify gaps in the literature and therefore direct further novel research in the field. Ultimately, this will inform public policy and strategies to reduce the inequalities in HNSCC survival.

Systematic review registration

PROSPERO CRD42016037019.
Appendix
Available only for authorised users
Literature
1.
Wilkinson R, Marmot M. Social determinants of health: the solid facts. Geneva: World Health Organisation; 2003.
2.
Conway DI, Brenner DR, McMahon AD, Macpherson LM, Agudo A, Ahrens W, et al. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. Int J Cancer. 2015;136(5):1125–39.CrossRefPubMed
3.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.CrossRefPubMed
4.
Parkin D, Whelan S, Ferlay J, Teppo L, Thomas D. Cancer incidence in five continents. Lyon: IARC Scientific Publications; 2003. VIII
5.
Pulte D, Brenner H. Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis. Oncologist. 2010;15(9):994–1001.CrossRefPubMedPubMedCentral
6.
Salazar CR, Anayannis N, Smith RV, Wang Y, Haigentz M Jr, Garg M, et al. Combined P16 and human papillomavirus testing predicts head and neck cancer survival. Int J Cancer. 2014;135(10):2404–12.CrossRefPubMedPubMedCentral
7.
Pfister DG, Fury MG. New chapter in our understanding of human papillomavirus-related head and neck cancer. J Clin Oncol. 2014;32(30):3349–52.CrossRefPubMed
8.
Allison PJ. Factors associated with smoking and alcohol consumption following treatment for head and neck cancer. Oral Oncol. 2001;37(6):513–20.CrossRefPubMed
9.
Healthcare Quality Improvement Partnership. National Head and Neck Cancer Audit 2013. 9th Edition. Leeds: Health and Social Care Information Centre.
10.
Tempest MJ, Thurston S, Carroll SM, Keeping ST. PCN56 preliminary results from a study of hospital costs due to treatment of head and neck cancers in England. Value Health. 2012;15(7):A418–A9.
11.
Bradley CJ, Yabroff KR, Dahman B, Feuer EJ, Mariotto A, Brown ML. Productivity costs of cancer mortality in the United States: 2000–2020. J Natl Cancer Inst. 2008;100(24):1763–70.CrossRefPubMedPubMedCentral
12.
Robertson G, Greenlaw N, Bray CA, Morrison DS. Explaining the effects of socio-economic deprivation on survival in a national prospective cohort study of 1909 patients with head and neck cancers. Cancer Epidemiol. 2010;34(6):682–8.CrossRefPubMed
13.
McDonald JT, Johnson-Obaseki S, Hwang E, Connell C, Corsten M. The relationship between survival and socio-economic status for head and neck cancer in Canada. J Otolaryngol Head Neck Surg. 2014;43(1):2.CrossRefPubMedPubMedCentral
14.
15.
Groome PA, Schulze KM, Keller S, Mackillop WJ, O'Sullivan B, Irish JC, et al. Explaining socioeconomic status effects in laryngeal cancer. Clin Oncol (R Coll Radiol). 2006;18(4):283–92.CrossRef
16.
Elwood JM, Pearson JC, Skippen DH, Jackson SM. Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and larynx. Int J Cancer. 1984;34(5):603–12.CrossRefPubMed
17.
Ragin CC, Langevin SM, Marzouk M, Grandis J, Taioli E. Determinants of head and neck cancer survival by race. Head Neck. 2011;33(8):1092–8.CrossRefPubMed
18.
Miller CS, Henry RG, Rayens MK. Disparities in risk of and survival from oropharyngeal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):570–5.CrossRefPubMed
19.
Konski A, Berkey BA, Kian Ang K, Fu KK. Effect of education level on outcome of patients treated on radiation therapy oncology group protocol 90–03. Cancer. 2003;98(7):1497–503.CrossRefPubMed
20.
Reitzel LR, Nguyen N, Zafereo ME, Li G, Wei Q, Sturgis EM. Neighborhood deprivation and clinical outcomes among head and neck cancer patients. Health Place. 2012;18(4):861–8.CrossRefPubMedPubMedCentral
21.
Mackillop WJ, Zhang-Salomons J, Groome PA, Paszat L, Holowaty E. Socioeconomic status and cancer survival in Ontario. J Clin Oncol. 1997;15(4):1680–9.CrossRefPubMed
22.
23.
Coyne JC, Pajak TF, Harris J, Konski A, Movsas B, Ang K, et al. Emotional well-being does not predict survival in head and neck cancer patients: a Radiation Therapy Oncology Group study. Cancer. 2007;110(11):2568–75.CrossRefPubMed
24.
Diderichsen F, Evans T, Whitehead M. The social basis of disparities in health. In: Evans T, Whitehead M, Diderichsen F, Bhuiya A, Wirth M, editors. Challenging inequities in health: from ethics to action. New York: Oxford University Press; 2001.
25.
Krieger N. Defining and investigating social disparities in cancer: critical issues. Cancer Causes Control. 2005;16(1):5–14.CrossRefPubMed
26.
Krieger N, Emmons KM, White KB. Cancer disparities: developing a multidisciplinary research agenda—preface. Cancer Causes Control. 2005;16(1):1–3.CrossRefPubMed
27.
28.
Newton JN, Briggs ADM, Murray CJL, Dicker D, Foreman KJ, Wang H, et al. Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(10010):2257–74.CrossRefPubMedPubMedCentral
29.
Conway DI, Brewster DH, McKinney PA, Stark J, McMahon AD, Macpherson LMD. Widening socio-economic inequalities in oral cancer incidence in Scotland, 1976–2002. Br J Cancer. 2007;96(5):818–20.CrossRefPubMedPubMedCentral
30.
31.
Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.CrossRefPubMedPubMedCentral
32.
Ogilvie D, Fayter D, Petticrew M, Sowden A, Thomas S, Whitehead M, et al. The harvest plot: a method for synthesising evidence about the differential effects of interventions. BMC Med Res Methodol. 2008;8(1):8.CrossRefPubMedPubMedCentral
Metadata
Title
Protocol: systematic review of the association between socio-economic status and survival in adult head and neck cancer
Authors
Bilal G. Taib
Joseph Rylands
Sue Povall
Terry M. Jones
David Taylor-Robinson
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2017
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-017-0545-0

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