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Open Access 01-12-2017 | Protocol

Therapies for bruxism: a systematic review and network meta-analysis (protocol)

Authors: Mauro Elias Mesko, Brian Hutton, Jovito Adiel Skupien, Rafael Sarkis-Onofre, David Moher, Tatiana Pereira-Cenci

Published in: Systematic Reviews | Issue 1/2017

Abstract

Background

Bruxism is a sleep disorder characterized by grinding and clenching of the teeth that may be related to irreversible tooth injuries. It is a prevalent condition occurring in up to 31% of adults. However, there is no definitive answer as to which of the many currently available treatments (including drug therapy, intramuscular injections, physiotherapy, biofeedback, kinesiotherapy, use of intraoral devices, or psychological therapy) is the best for the clinical management of the different manifestations of bruxism. The aim of this systematic review and network meta-analysis is to answer the following question: what is the best treatment for adult bruxists?

Methods/design

Comprehensive searches of the Cochrane Library, MEDLINE (via PubMed), Scopus, and LILACS will be completed using the following keywords: bruxism and therapies and related entry terms. Studies will be included, according to the eligibility criteria (Controlled Clinical Trials and Randomized Clinical Trials, considering specific outcome measures for bruxism). The reference lists of included studies will be hand searched. Relevant data will be extracted from included studies using a specially designed data extraction sheet. Risk of bias of the included studies will be assessed, and the overall strength of the evidence will be summarized (i.e., GRADE). A random effects model will be used for all pairwise meta-analyses (with a 95% confidence interval). A Bayesian network meta-analysis will explore the relative benefits between the various treatments. The review will be reported using the Preferred Reporting Items for Systematic Reviews incorporating Network Meta-Analyses (PRISMA-NMA) statement.

Discussion

This systematic review aims at identifying and evaluating therapies to treat bruxism. This systematic review may lead to several recommendations, for both patients and researchers, as which is the best therapy for a specific patient case and how future studies need to be designed, considering what is available now and what is the reality of the patient.

Systematic review registration

PROSPERO CRD42015023308

Available only for authorised users

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Title: Therapies for bruxism: a systematic review and network meta-analysis (protocol)
Authors: Mauro Elias Mesko
Brian Hutton
Jovito Adiel Skupien
Rafael Sarkis-Onofre
David Moher
Tatiana Pereira-Cenci
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Systematic Reviews / Issue 1/2017
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-016-0397-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Therapies for bruxism: a systematic review and network meta-analysis (protocol)

Abstract

Background

Methods/design

Discussion

Systematic review registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/design

Discussion

Systematic review registration

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