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Systematic Reviews
Published in: Systematic Reviews 1/2016

Open Access 01-12-2016 | Protocol

What change in body mass index is needed to improve metabolic health status in childhood obesity: protocol for a systematic review

Authors: Laura Birch, Rachel Perry, Chris Penfold, Rhona Beynon, Julian Hamilton-Shield

Published in: Systematic Reviews | Issue 1/2016

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Abstract

Background

Childhood obesity is one of the most serious, global, public health challenges and has adverse health consequences in both the short-and long-term. The purpose of this study is to establish the change in body mass index (BMI) needed to achieve improvements in metabolic health status in obese children and adolescents attending lifestyle treatment interventions.

Methods

The following electronic databases will be searched from their inception: AMED, Embase, MEDLINE via OVID, Web of Science and CENTRAL via Cochrane library. Randomised controlled trials (RCTs) or cohort studies of lifestyle interventions (i.e. dietary, physical activity and/or behavioural therapy) for treating obesity in children and adolescents (4–18 years) will be included. Interventions that last less than 2 weeks and trials that include overweight participants or those with a secondary or syndromic cause of obesity will not be included. No language restrictions will be applied. Titles and abstracts will be assessed for eligibility by two reviewers, and data from full-text articles will be extracted using a standardised data extraction template. Reference lists of all included articles will be hand-searched for additional publications. A narrative synthesis of the findings will be presented, and meta-analysis will be conducted if considered appropriate.

Discussion

This will be the first systematic review of studies to establish the change in BMI required to improve metabolic health status in obese children and adolescents.

Systematic review registration

Appendix
Available only for authorised users
Literature
1.
2.
3.
Simmonds M, Llewellyn A, Owen C and Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obesity reviews. 2015; doi: 10.​1111/​obr.​12334.
4.
Hannon T, Goutham R, Arslanian S. Childhood obesity and type 2 diabetes mellitus. Pediatrics. 2005;116:473–80.CrossRefPubMed
5.
Haines L, Wan KC, Lynn R, Barrett TG, Shield JPH. Rising incidence of type 2 diabetes in children in the U.K. Diabetes Care. 2007;30(5):1097–101.CrossRefPubMed
6.
Urbina E, Kimball T, McCoy C, Khoury P, Daniels S, Dolan L. Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation. 2009;119(22):2913–9.CrossRefPubMedPubMedCentral
7.
Pires A, Martins P, Pereira AM, Silva PV, Marinho J, Marques M, et al. Insulin resistance, dyslipidaemia and cardiovascular changes in a group of obese children. Arg Bras Cardiol. 2015;104(4):266–73.
8.
9.
Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol. 2008;159 Suppl 1:S67–74.CrossRefPubMed
10.
Tounian P, Aggoun Y, Dubern B, Varille V, Guy-Grand B, Sidi D, et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 2001;359(9291):1400–4.CrossRef
11.
Klein S, Burke L, Bray G, et al. Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation. 2004;110(18):2952–67.CrossRefPubMed
12.
Krebs JD, Evans S, Cooney L, et al. Changes in risk factors for cardiovascular disease with body fat loss in obese women. Diabetes Obe Metab. 2002;4(6):379–87.CrossRef
13.
National Heart, Lung, and Blood Institute. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;6(suppl):51S–210.
14.
Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O’Malley C, Stolk RP, Summerbell CD. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009;(1):CD001872. doi: 10.​1002/​14651858.​CD001872.​pub2.
15.
16.
Ford AL, Hunt LP, Cooper A, Shield JPH. What reduction in BMI SDS is required in obese adolescents to improve body composition and cardiometabolic health? Arch Dis Child. 2010;95(4):256–61.CrossRefPubMed
17.
Wei C, Ford A, Hunt L, Crowne EC, Shield JPH. Abnormal liver function in children with metabolic syndrome from a UK-based obesity clinic. Arch Dis Child. 2011;96(11):1003–7.CrossRefPubMed
18.
19.
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data. 2000;314:1–28.
20.
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320:1240–53.CrossRefPubMedPubMedCentral
21.
De Onis M, Garza C, Onyango AW, Borghi E. Comparison of the WHO child growth standards and the CDC 2000 growth charts. J Nutr. 2007;137(1):144–8.PubMed
22.
De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85(9):660–7.CrossRefPubMedPubMedCentral
23.
Avenell A, Broom J, Brown TJ, Poobalan A, Aucott L, Stearns SC, et al. Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess. 2004; 8(21).
24.
Metadata
Title
What change in body mass index is needed to improve metabolic health status in childhood obesity: protocol for a systematic review
Authors
Laura Birch
Rachel Perry
Chris Penfold
Rhona Beynon
Julian Hamilton-Shield
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2016
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-016-0299-0

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