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Published in: Systematic Reviews 1/2016

Open Access 01-12-2016 | Protocol

The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol

Authors: Kuan-Wen Wang, Marlie Valencia, Laura Banfield, Ruth Chau, Adam Fleming, Sheila K. Singh, Sarah Burrow, Russell J. de Souza, Lehana Thabane, M. Constantine Samaan

Published in: Systematic Reviews | Issue 1/2016

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Abstract

Background

Pediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood brain tumors (SCBT). However, these survivors are at an increased risk of obesity and cardiometabolic disorders that affect their quality of life and lifespan. It is important to define effective strategies to treat and prevent obesity in this population. This systematic review aims to investigate the effectiveness of lifestyle interventions, pharmacotherapy, and bariatric surgery on treating obesity in SCBT.

Methods

Searches will be conducted in PubMed, MEDLINE, EMBASE, PsycINFO, SPORTDiscus, CINAHL, Cochrane Database of Systematic Review, Cochrane Central Register of Controlled Trials (CENTRAL), and Database of Abstracts of Reviews of Effect (DARE). In addition, ClinicalTrials.gov and ProQuest Dissertations and Theses A&I will be searched to identify relevant gray literature. The reference lists of eligible articles will be searched for additional studies. All screening, quality assessment, and data abstraction will be done independently by two reviewers. We will perform meta-analysis if there are sufficient studies.

Discussion

This review will summarize evidence for the effectiveness of interventions used to reduce obesity risk in SCBT. This has significant implications for SCBT, as it can identify gaps in knowledge and provide insights into the development of new interventions to manage obesity in survivors, which may improve their outcomes.

Systematic review registration

Appendix
Available only for authorised users
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Metadata
Title
The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol
Authors
Kuan-Wen Wang
Marlie Valencia
Laura Banfield
Ruth Chau
Adam Fleming
Sheila K. Singh
Sarah Burrow
Russell J. de Souza
Lehana Thabane
M. Constantine Samaan
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2016
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-016-0274-9

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