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Annals of Intensive Care

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01-12-2020 | Pneumonia | Research

Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

Authors: Olivier Pouly, Sylvain Lecailtel, Sophie Six, Sébastien Préau, Frédéric Wallet, Saad Nseir, Anahita Rouzé

Published in: Annals of Intensive Care | Issue 1/2020

Abstract

Background

The aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.

Methods

This retrospective study was performed in five 10-bed ICUs of a teaching hospital, during a 2-year period. Ventilator-associated lower respiratory tract infections (VA-LRTI), including ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) were prospectively diagnosed. The agreement between VAE, VAT and VAP was assessed by k statistics.

Results

A total of 1059 patients (15,029 ventilator-days) were included. 268 VAP (17.8 per 1000 ventilator-days), 127 VAT (8.5 per 1000 ventilator-days) and 262 VAE (17.4 per 1000 ventilator-days) were diagnosed. There was no agreement between VAT and VAE, and the agreement was poor between VAP and VAE (k = 0.12, 95% CI 0.03–0.20). VAE and VA-LRTI were associated with significantly longer duration of mechanical ventilation, ICU and hospital length of stay. VAP, VAT and VAE were not significantly associated with mortality in multivariate analysis.

Conclusions

The agreement was poor between VAE and VAP. No agreement was found between VAE and VAT. VAE episodes were significantly associated with longer duration of mechanical ventilation and length of stay, but not with ICU mortality.

Available only for authorised users

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Title: Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections
Authors: Olivier Pouly
Sylvain Lecailtel
Sophie Six
Sébastien Préau
Frédéric Wallet
Saad Nseir
Anahita Rouzé
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keyword: Pneumonia
Published in: Annals of Intensive Care / Issue 1/2020
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-020-0624-6

At a glance: The STEP trials

Springer Medicine

Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infections

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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