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Open Access 01-12-2019 | Acute Respiratory Distress-Syndrome | Editorial

Hemoadsorption therapy in the critically ill: solid base but clinical haze

Authors: Patrick M. Honoré, David De Bels, Leonel Barreto Gutierrez, Herbert D. Spapen

Published in: Annals of Intensive Care | Issue 1/2019

Excerpt

In a recent issue of Annals of Intensive Care, Xu et al. [1] studied the efficacy of HA330 resin-directed hemoadsorption (HA) in an endotoxin-induced porcine acute respiratory distress syndrome (ARDS) model. HA330-HA improved oxygenation and lung mechanics, blunted lung edema and histopathological signs of ARDS, reduced circulating and alveolar cytokine levels, and profoundly changed plasma and lung proteome. The authors hypothesized that HA330-HA could beneficially influence the course of ARDS by attenuating systemic and pulmonary inflammatory cytokine “overshooting” and by restoring disordered proteome homeostasis in the exudative phase [1]. …

Xu X, Jia C, Luo S, Li Y, Xiao F, Dai H, et al. Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model. Ann Intensive Care. 2017;7(1):84. https://doi.org/10.1186/s13613-017-0287-0.CrossRefPubMedPubMedCentral

Honoré PM, De Bels D, Spapen HD. An update on membranes and cartridges for extracorporeal blood purification in sepsis and septic shock. Curr Opin Crit Care. 2018;24(6):463–8. https://doi.org/10.1097/MCC.0000000000000542.CrossRefPubMed

Honore PM, Jacobs R, Joannes-Boyau O, De Regt J, De Waele E, van Gorp V, et al. Newly designed CRRT membranes for sepsis and SIRS—a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review. ASAIO J. 2013;59(2):99–106. https://doi.org/10.1097/mat.0b013e3182816a75.CrossRefPubMed

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Ankawi G, Fan W, Pomarè Montin D, Lorenzin A, Neri M, Caprara C, et al. A new series of sorbent devices for multiple clinical purposes: current evidence and future directions. Blood Purif. 2018. https://doi.org/10.1159/000493523.CrossRefPubMed

Huang Z, Wang SR, Su W, Liu JY. Removal of humoral mediators and the effect on the survival of septic patients by hemoperfusion with neutral microporous resin column. Ther Apher Dial. 2010;14(6):596–602.CrossRef

Huang Z, Wang SR, Yang ZL, Liu JY. Effect on extrapulmonary sepsis-induced acute lung injury by hemoperfusion with neutral microporous resin column. Ther Apher Dial. 2013;17:454–61.CrossRef

Friesecke S, Träger K, Schittek GA, Molnar Z, Bach F, Kogelmann K, et al. International registry on the use of the CytoSorb^® adsorber in ICU patients: study protocol and preliminary results. Med Klin Intensivmed Notfmed. 2017. https://doi.org/10.1007/s00063-017-0342-5.CrossRefPubMed

Schädler D, Pausch C, Heise D, Meier-Hellmann A, Brederlau J, Weiler N, et al. The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: a randomized controlled trial. PLoS ONE. 2017;12(10):e0187015. https://doi.org/10.1371/journal.pone.0187015.CrossRefPubMedPubMedCentral

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Hawchar F, László I, Öveges N, Trásy D, Ondrik Z, Molnar Z. Extracorporeal cytokine adsorption in septic shock: a proof of concept randomized, controlled pilot study. J Crit Care. 2019;49:172–8. https://doi.org/10.1016/j.jcrc.2018.11.003.CrossRefPubMed

Title: Hemoadsorption therapy in the critically ill: solid base but clinical haze
Authors: Patrick M. Honoré
David De Bels
Leonel Barreto Gutierrez
Herbert D. Spapen
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keywords: Acute Respiratory Distress-Syndrome
Cytokines
Published in: Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-019-0491-1

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