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Published in: Annals of Intensive Care 1/2017

Open Access 01-12-2017 | Research

Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions

Authors: Jordi Vallés, Susana Millán, Emili Díaz, Eva Castanyer, Xavier Gallardo, Ignacio Martín-Loeches, Marta Andreu, Mario Prenafeta, Paula Saludes, Jorge Lema, Montse Batlle, Néstor Bacelar, Antoni Artigas

Published in: Annals of Intensive Care | Issue 1/2017

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Abstract

Background

Continuous aspiration of subglottic secretions is effective in preventing ventilator-associated pneumonia, but it involves a risk of mucosal damage. The main objective of our study was to determine the incidence of airway complications related to continuous aspiration of subglottic secretions.

Methods

In consecutive adult patients with continuous aspiration of subglottic secretions, we prospectively recorded clinical airway complications during the period after extubation. A multidetector computed tomography of the neck was performed during the period of 5 days following extubation to classify subglottic and tracheal lesions as mucosal thickening, cartilage thickening or deep ulceration.

Results

In the 86 patients included in the study, 6 (6.9%) had transient dyspnea, 7 (8.1%) had upper airway obstruction and 18 (20.9%) had dysphonia at extubation. Univariate analysis identified more attempts required for intubation (2.3 ± 1.1 vs. 1.2 ± 0.5; p = 0.001), difficult intubation (71.4 vs. 10.1%, p = 0.001) and Cormack score III–IV (71.4 vs. 8.8%; p < 0.001) as risk factors for having an upper airway obstruction at extubation. The incidence of failed extubation among patients after planned extubation was 18.9% and 11 patients (12.7%) required tracheostomy. A multidetector computed tomography was performed in 37 patients following extubation, and injuries were observed in 9 patients (24.3%) and classified as tracheal injuries in 2 patients (1 cartilage thickening and 1 mild stenosis with cartilage thickening) and as subglottic mucosal thickenings in 7 patients.

Conclusions

The incidence of upper airway obstruction after extubation in patients with continuous aspiration of subglottic secretions was 8.1%, and the injuries observed by computed tomography were not severe and located mostly in subglottic space.
Literature
1.
go back to reference Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010;38:1947–53.CrossRefPubMed Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010;38:1947–53.CrossRefPubMed
2.
go back to reference Stefan MS, Shieh MS, Pekow PS, Rothberg MB, Steingrub JS, Lagu T, Lindenauer PK. Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. J Hosp Med. 2013;8:76–82.CrossRefPubMedPubMedCentral Stefan MS, Shieh MS, Pekow PS, Rothberg MB, Steingrub JS, Lagu T, Lindenauer PK. Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. J Hosp Med. 2013;8:76–82.CrossRefPubMedPubMedCentral
3.
go back to reference Magill SS, Klompas M, Balk R, Burns SM, Deutschman CS, Diekema D, Fridkin S, Greene L, Guh A, Gutterman D, Hammer B, Henderson D, Hess D, Hill NS, Horan T, Kollef M, Levy M, Septimus E, Vanantwerpen C, Wright D, Lipsett P. Developing a new, national approach to surveillance for ventilator-associated events. Crit Care Med. 2013;41:2467–75.CrossRefPubMed Magill SS, Klompas M, Balk R, Burns SM, Deutschman CS, Diekema D, Fridkin S, Greene L, Guh A, Gutterman D, Hammer B, Henderson D, Hess D, Hill NS, Horan T, Kollef M, Levy M, Septimus E, Vanantwerpen C, Wright D, Lipsett P. Developing a new, national approach to surveillance for ventilator-associated events. Crit Care Med. 2013;41:2467–75.CrossRefPubMed
4.
go back to reference Safdar N, Defzulian C, Collard HR, Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med. 2005;33:2184–93.CrossRefPubMed Safdar N, Defzulian C, Collard HR, Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med. 2005;33:2184–93.CrossRefPubMed
5.
go back to reference Lorente L, Blot S, Rello J. Evidence on measures for the prevention of ventilator-associated pneumonia. EurRespir J. 2007;30:1193–207.CrossRef Lorente L, Blot S, Rello J. Evidence on measures for the prevention of ventilator-associated pneumonia. EurRespir J. 2007;30:1193–207.CrossRef
6.
go back to reference Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med. 2011;39:1985–91.CrossRefPubMed Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med. 2011;39:1985–91.CrossRefPubMed
7.
go back to reference Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005;118:11–8.CrossRefPubMed Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005;118:11–8.CrossRefPubMed
8.
go back to reference Vallés J, Artigas A, Rello J, Bonsoms N, Fontanals D, Blanch L, Fernández R, Baigorri F, Mestre J. Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med. 1995;122:179–86.CrossRefPubMed Vallés J, Artigas A, Rello J, Bonsoms N, Fontanals D, Blanch L, Fernández R, Baigorri F, Mestre J. Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med. 1995;122:179–86.CrossRefPubMed
9.
go back to reference Berra L, De Marchi L, Panigada M, Yu ZX, Baccarelli A, Kolobow T. Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med. 2004;32:2071–8.CrossRefPubMed Berra L, De Marchi L, Panigada M, Yu ZX, Baccarelli A, Kolobow T. Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med. 2004;32:2071–8.CrossRefPubMed
10.
go back to reference Girou E, Buu-Hoi A, Stephan F, Novara A, Gutmann L, Safar M, Fagon JY. Airwaycolonisation in long-term mechanically ventilated patients. Effect of semi-recumbent position and continuous subglottic suctioning. Intensive Care Med. 2004;30:225–33.CrossRefPubMed Girou E, Buu-Hoi A, Stephan F, Novara A, Gutmann L, Safar M, Fagon JY. Airwaycolonisation in long-term mechanically ventilated patients. Effect of semi-recumbent position and continuous subglottic suctioning. Intensive Care Med. 2004;30:225–33.CrossRefPubMed
11.
go back to reference Harvey RC, Miller P, Lee JA, Bowton DL, MacGregor DA. Potential mucosal injury related to continuous aspiration of subglottic secretion device. Anesthesiology. 2007;107:666–9.CrossRefPubMed Harvey RC, Miller P, Lee JA, Bowton DL, MacGregor DA. Potential mucosal injury related to continuous aspiration of subglottic secretion device. Anesthesiology. 2007;107:666–9.CrossRefPubMed
12.
go back to reference Dragoumanis CK, Vretzakis GI, Papaioannou VE, Didilis VN, Vogiatzaki TD, Pneumatikos IA. Investigating the failure to aspirate subglottic secretions with the Evac endotracheal tube. Anesth Analg. 2007;105:1083–5.CrossRefPubMed Dragoumanis CK, Vretzakis GI, Papaioannou VE, Didilis VN, Vogiatzaki TD, Pneumatikos IA. Investigating the failure to aspirate subglottic secretions with the Evac endotracheal tube. Anesth Analg. 2007;105:1083–5.CrossRefPubMed
13.
go back to reference Touat L, Fournier C, Ramon P, Salleron J, Durocher A, Nseir S. Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome. Intensive Care Med. 2013;39:575–82.CrossRefPubMed Touat L, Fournier C, Ramon P, Salleron J, Durocher A, Nseir S. Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome. Intensive Care Med. 2013;39:575–82.CrossRefPubMed
14.
go back to reference Apfelbaum JL, Hagberg CA, Caplan RA, Blitt CD, Connis RT, Nickinovich DG, Hagberg CA, Caplan RA, Benumof JL, Berry FA, Blitt CD, Bode RH, Cheney FW, Connis RT, Guidry OF, Nickinovich DG, Ovassapian A. Practice guidelines for management of the difficult airway: an updated report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway. Anesthesiology. 2013;118:251–70.CrossRefPubMed Apfelbaum JL, Hagberg CA, Caplan RA, Blitt CD, Connis RT, Nickinovich DG, Hagberg CA, Caplan RA, Benumof JL, Berry FA, Blitt CD, Bode RH, Cheney FW, Connis RT, Guidry OF, Nickinovich DG, Ovassapian A. Practice guidelines for management of the difficult airway: an updated report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway. Anesthesiology. 2013;118:251–70.CrossRefPubMed
15.
go back to reference Kastanos N, Estopá R, Marín A, Xaubet A, Agustí-Vidal A. Laryngotracheal injury due to endotracheal intubation: incidence, evolution, and predisposing factors. A prospective long-term study. Crit Care Med. 1983;11:362–7.CrossRefPubMed Kastanos N, Estopá R, Marín A, Xaubet A, Agustí-Vidal A. Laryngotracheal injury due to endotracheal intubation: incidence, evolution, and predisposing factors. A prospective long-term study. Crit Care Med. 1983;11:362–7.CrossRefPubMed
16.
go back to reference Stauffer JL, Olson DE, Petty TL. Complications and consequences of endotracheal intubation and tracheotomy.A prospective study of 150 critically ill adult patients. Am J Med. 1981;70:65–76.CrossRefPubMed Stauffer JL, Olson DE, Petty TL. Complications and consequences of endotracheal intubation and tracheotomy.A prospective study of 150 critically ill adult patients. Am J Med. 1981;70:65–76.CrossRefPubMed
17.
go back to reference Morshed K, Trojanowska A, Szymański M, Trojanowski P, Szymańska A, Smoleń A, Drop A. Evaluation of tracheal stenosis: comparison between computed tomography virtual tracheobronchoscopy with multiplanar reformatting, flexible tracheofiberoscopy and intra-operative findings. Eur Arch Otorhinolaryngol. 2011;268:591–7.CrossRefPubMed Morshed K, Trojanowska A, Szymański M, Trojanowski P, Szymańska A, Smoleń A, Drop A. Evaluation of tracheal stenosis: comparison between computed tomography virtual tracheobronchoscopy with multiplanar reformatting, flexible tracheofiberoscopy and intra-operative findings. Eur Arch Otorhinolaryngol. 2011;268:591–7.CrossRefPubMed
18.
go back to reference Hoppe H, Dinkel H-P, Walder B, von Allmen G, Gugger M, Vock P. Grading airway stenosis down to the segmental level using virtual bronchoscopy. Chest. 2004;125:704–11.CrossRefPubMed Hoppe H, Dinkel H-P, Walder B, von Allmen G, Gugger M, Vock P. Grading airway stenosis down to the segmental level using virtual bronchoscopy. Chest. 2004;125:704–11.CrossRefPubMed
19.
go back to reference Taha MS, Mostafa BE, Fahmy M, Ghaffar MK, Ghany EA. Spiral CT virtual bronchoscopy with multiplanar reformatting in the evaluation of post-intubation tracheal stenosis: comparison between endoscopic, radiological and surgical findings. Eur Arch Otorhinolaryngol. 2009;266:863–6.CrossRefPubMed Taha MS, Mostafa BE, Fahmy M, Ghaffar MK, Ghany EA. Spiral CT virtual bronchoscopy with multiplanar reformatting in the evaluation of post-intubation tracheal stenosis: comparison between endoscopic, radiological and surgical findings. Eur Arch Otorhinolaryngol. 2009;266:863–6.CrossRefPubMed
20.
go back to reference Sun M, Ernst A, Boiselle P. MDCT of the central airways. Comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubes. J Thorac Imaging. 2007;22:136–42.CrossRefPubMed Sun M, Ernst A, Boiselle P. MDCT of the central airways. Comparison with bronchoscopy in the evaluation of complications of endotracheal and tracheostomy tubes. J Thorac Imaging. 2007;22:136–42.CrossRefPubMed
21.
go back to reference Pluijms WA, van Mook W, Wittekamp BH, Bergmans D. Postextubation laryngeal edema and stridor resulting in respiratory failure in critically ill patients: updated review. Crit Care. 2015;19:295.CrossRefPubMedPubMedCentral Pluijms WA, van Mook W, Wittekamp BH, Bergmans D. Postextubation laryngeal edema and stridor resulting in respiratory failure in critically ill patients: updated review. Crit Care. 2015;19:295.CrossRefPubMedPubMedCentral
22.
go back to reference Darmon JY, Rauss A, Dreyfuss D, Bleichner G, Elkharrat D, Schlemmer B, Tenaillon A, Brun-Buisson C, Huet Y. Evaluation of risk factors for laryngeal edema after tracheal extubation in adults and its prevention by dexamethasone: a placebo-controlled, double-blind, multicenter study. Anesthesiology. 1992;77:245–51.CrossRefPubMed Darmon JY, Rauss A, Dreyfuss D, Bleichner G, Elkharrat D, Schlemmer B, Tenaillon A, Brun-Buisson C, Huet Y. Evaluation of risk factors for laryngeal edema after tracheal extubation in adults and its prevention by dexamethasone: a placebo-controlled, double-blind, multicenter study. Anesthesiology. 1992;77:245–51.CrossRefPubMed
23.
go back to reference François B, Bellissant E, Gissot V, Desachy A, Normand S, Boulain T, Brenet O, Preux PM, Vignon P, Association des Réanimateurs du Centre-Ouest (ARCO). 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial. Lancet. 2007;369:1083–9.CrossRefPubMed François B, Bellissant E, Gissot V, Desachy A, Normand S, Boulain T, Brenet O, Preux PM, Vignon P, Association des Réanimateurs du Centre-Ouest (ARCO). 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial. Lancet. 2007;369:1083–9.CrossRefPubMed
24.
go back to reference Thille AW, Richard J-CM, Brochard L. The decision of extubate in the intensive care unit. Am J Respir Crit Care Med. 2013;187:1294–302.CrossRefPubMed Thille AW, Richard J-CM, Brochard L. The decision of extubate in the intensive care unit. Am J Respir Crit Care Med. 2013;187:1294–302.CrossRefPubMed
25.
go back to reference Vallverdú I, Calaf N, Subirana M, Net A, Benito S, Mancebo J. Clinical characteristics, respiratory functional parameters, and outcome of a two-hour T-piece trial in patients weaning from mechanical ventilation. Am J Respir Crit Care Med. 1998;158:1855–62.CrossRefPubMed Vallverdú I, Calaf N, Subirana M, Net A, Benito S, Mancebo J. Clinical characteristics, respiratory functional parameters, and outcome of a two-hour T-piece trial in patients weaning from mechanical ventilation. Am J Respir Crit Care Med. 1998;158:1855–62.CrossRefPubMed
26.
go back to reference Namen AM, Ely EW, Tatter SB, Case LD, Lucia MA, Smith A, Landry S, Wilson JA, Glazier SS, Branch CL, Kelly DL, Bowton DL, Haponik EF. Predictors of successful extubation in neurosurgical patients. Am J Respir Crit Care Med. 2001;163:658–64.CrossRefPubMed Namen AM, Ely EW, Tatter SB, Case LD, Lucia MA, Smith A, Landry S, Wilson JA, Glazier SS, Branch CL, Kelly DL, Bowton DL, Haponik EF. Predictors of successful extubation in neurosurgical patients. Am J Respir Crit Care Med. 2001;163:658–64.CrossRefPubMed
27.
go back to reference Mokhlesi B, Tulaimat A, Gluckman TJ, Wang Y, Evans AT, Corbridge TC. Predicting extubation failure after successful completion of spontaneous breathing trial. Respir Care. 2007;52:1710–7.PubMed Mokhlesi B, Tulaimat A, Gluckman TJ, Wang Y, Evans AT, Corbridge TC. Predicting extubation failure after successful completion of spontaneous breathing trial. Respir Care. 2007;52:1710–7.PubMed
28.
go back to reference Kollef MH, Ahrens TS, Shannon W. Clinical predictors and outcomes for patients requiring tracheostomy in ten intensive care unit. Crit Care Med. 1999;27:1714–20.CrossRefPubMed Kollef MH, Ahrens TS, Shannon W. Clinical predictors and outcomes for patients requiring tracheostomy in ten intensive care unit. Crit Care Med. 1999;27:1714–20.CrossRefPubMed
29.
go back to reference Esteban A, Anzueto A, Alía I, Gordo F, Apezteguía C, Pálizas F, Cide D, Goldwaser R, Soto L, Bugedo G, Rodrigo C, Pimentel J, Raimondi G, Tobin MJ. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med. 2000;161:1450–8.CrossRefPubMed Esteban A, Anzueto A, Alía I, Gordo F, Apezteguía C, Pálizas F, Cide D, Goldwaser R, Soto L, Bugedo G, Rodrigo C, Pimentel J, Raimondi G, Tobin MJ. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med. 2000;161:1450–8.CrossRefPubMed
30.
go back to reference Fischler L, Erhart S, Kleger GR, Frutiger A. Prevalence of tracheostomy in ICU patients: a nation-wide survey in Switzerland. Intensive Care Med. 2000;26:1428–33.CrossRefPubMed Fischler L, Erhart S, Kleger GR, Frutiger A. Prevalence of tracheostomy in ICU patients: a nation-wide survey in Switzerland. Intensive Care Med. 2000;26:1428–33.CrossRefPubMed
31.
go back to reference Fernández R, Tizón AI, González J, Monedero P, Garcia-Sanchez M, de-la-Torre MV, Ibañez P, Frutos F, del-Nogal F, Gomez MJ, Marcos A, Hernández G, Sabadell Score Group. Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: a prospective, multicenter propensity analysis. Crit Care Med. 2011;39:2240–5.CrossRefPubMed Fernández R, Tizón AI, González J, Monedero P, Garcia-Sanchez M, de-la-Torre MV, Ibañez P, Frutos F, del-Nogal F, Gomez MJ, Marcos A, Hernández G, Sabadell Score Group. Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: a prospective, multicenter propensity analysis. Crit Care Med. 2011;39:2240–5.CrossRefPubMed
Metadata
Title
Incidence of airway complications in patients using endotracheal tubes with continuous aspiration of subglottic secretions
Authors
Jordi Vallés
Susana Millán
Emili Díaz
Eva Castanyer
Xavier Gallardo
Ignacio Martín-Loeches
Marta Andreu
Mario Prenafeta
Paula Saludes
Jorge Lema
Montse Batlle
Néstor Bacelar
Antoni Artigas
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Annals of Intensive Care / Issue 1/2017
Electronic ISSN: 2110-5820
DOI
https://doi.org/10.1186/s13613-017-0331-0

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