The safety and tolerability profile of bilastine for chronic urticaria in children

go back to reference Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, Bernstein JA, Bindslev-Jensen C, Brzoza Z, Buense Bedrikow R, Canonica GW, Church MK, Craig T, Danilycheva IV, Dressler C, Ensina LF, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Hebert J, Hide M, Kaplan A, Kapp A, Katelaris CH, Kocatürk E, Kulthanan K, Larenas-Linnemann D, Leslie TA, Magerl M, Mathelier-Fusade P, Meshkova RY, Metz M, Nast A, Nettis E, Oude-Elberink H, Rosumeck S, Saini SS, Sánchez-Borges M, Schmid-Grendelmeier P, Staubach P, Sussman G, Toubi E, Vena GA, Vestergaard C, Wedi B, Werner RN, Zhao Z, Maurer M. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73:1393–414.PubMedCrossRef Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, Bernstein JA, Bindslev-Jensen C, Brzoza Z, Buense Bedrikow R, Canonica GW, Church MK, Craig T, Danilycheva IV, Dressler C, Ensina LF, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Hebert J, Hide M, Kaplan A, Kapp A, Katelaris CH, Kocatürk E, Kulthanan K, Larenas-Linnemann D, Leslie TA, Magerl M, Mathelier-Fusade P, Meshkova RY, Metz M, Nast A, Nettis E, Oude-Elberink H, Rosumeck S, Saini SS, Sánchez-Borges M, Schmid-Grendelmeier P, Staubach P, Sussman G, Toubi E, Vena GA, Vestergaard C, Wedi B, Werner RN, Zhao Z, Maurer M. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73:1393–414.PubMedCrossRef

go back to reference Zuberbier T, Balke M, Worm M, Edenharter G, Maurer M. Epidemiology of urticaria: a representative cross-sectional population survey. Clin Exp Dermatol. 2010;35:869–73.PubMedCrossRef Zuberbier T, Balke M, Worm M, Edenharter G, Maurer M. Epidemiology of urticaria: a representative cross-sectional population survey. Clin Exp Dermatol. 2010;35:869–73.PubMedCrossRef

go back to reference Maurer M, Zuberbier T, Siebenhaar F, Krause K. Chronic urticaria—What does the new guideline tell us? J Dtsch Dermatol Ges. 2018;16:584–93.PubMedCrossRef Maurer M, Zuberbier T, Siebenhaar F, Krause K. Chronic urticaria—What does the new guideline tell us? J Dtsch Dermatol Ges. 2018;16:584–93.PubMedCrossRef

go back to reference Konstantinou GN, Papadopoulos NG, Tavladaki T, Tsekoura T, Tsilimigaki A, Grattan CE. Childhood acute urticaria in northern and southern Europe shows a similar epidemiological pattern and significant meteorological influences. Pediatr Allergy Immunol. 2011;22:36–42.PubMedCrossRef Konstantinou GN, Papadopoulos NG, Tavladaki T, Tsekoura T, Tsilimigaki A, Grattan CE. Childhood acute urticaria in northern and southern Europe shows a similar epidemiological pattern and significant meteorological influences. Pediatr Allergy Immunol. 2011;22:36–42.PubMedCrossRef

go back to reference Tang N, Mao MY, Zhai R, Chen X, Zhang JL, Zhu W, Li J. Clinical characteristics of urticaria in children versus adults. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:790–5.PubMed Tang N, Mao MY, Zhai R, Chen X, Zhang JL, Zhu W, Li J. Clinical characteristics of urticaria in children versus adults. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:790–5.PubMed

go back to reference Netchiporouk E, Sasseville D, Moreau L, Habel Y, Rahme E, Ben-Shoshan M. Evaluating comorbidities, natural history, and predictors of early resolution in a cohort of children with chronic urticaria. JAMA Dermatol. 2017;153:1236–42.PubMedPubMedCentralCrossRef Netchiporouk E, Sasseville D, Moreau L, Habel Y, Rahme E, Ben-Shoshan M. Evaluating comorbidities, natural history, and predictors of early resolution in a cohort of children with chronic urticaria. JAMA Dermatol. 2017;153:1236–42.PubMedPubMedCentralCrossRef

go back to reference Church MK, Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunol Rev. 2018;282:232–47.PubMedCrossRef Church MK, Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunol Rev. 2018;282:232–47.PubMedCrossRef

go back to reference Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL. International union of basic and clinical pharmacology. XCVIII. Histamine receptors. Pharmacol Rev. 2015;67:601–55.PubMedPubMedCentralCrossRef Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL. International union of basic and clinical pharmacology. XCVIII. Histamine receptors. Pharmacol Rev. 2015;67:601–55.PubMedPubMedCentralCrossRef

go back to reference Grob JJ, Auquier P, Dreyfus I, Ortonne JP. How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Allergy. 2009;64:605–12.PubMedCrossRef Grob JJ, Auquier P, Dreyfus I, Ortonne JP. How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Allergy. 2009;64:605–12.PubMedCrossRef

go back to reference Weller K, Ardelean E, Scholz E, Martus P, Zuberbier T, Maurer M. Can on-demand non-sedating antihistamines improve urticaria symptoms? A double-blind, randomized, single-dose study. Acta Derm Venereol. 2013;93:168–74.PubMedCrossRef Weller K, Ardelean E, Scholz E, Martus P, Zuberbier T, Maurer M. Can on-demand non-sedating antihistamines improve urticaria symptoms? A double-blind, randomized, single-dose study. Acta Derm Venereol. 2013;93:168–74.PubMedCrossRef

go back to reference Church MK. Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opin Drug Saf. 2011;10:779–93.PubMedCrossRef Church MK. Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opin Drug Saf. 2011;10:779–93.PubMedCrossRef

go back to reference Bosma R, van den Bor J, Vischer HF, Labeaga L, Leurs R. The long duration of action of the second-generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor. Eur J Pharmacol. 2018;5:107–11.CrossRef Bosma R, van den Bor J, Vischer HF, Labeaga L, Leurs R. The long duration of action of the second-generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor. Eur J Pharmacol. 2018;5:107–11.CrossRef

go back to reference Jauregizar N, de la Fuente L, Lucero ML, Sologuren A, Leal N, Rodríguez M. Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet. 2009;48:543–54.PubMedCrossRef Jauregizar N, de la Fuente L, Lucero ML, Sologuren A, Leal N, Rodríguez M. Pharmacokinetic-pharmacodynamic modelling of the antihistaminic (H1) effect of bilastine. Clin Pharmacokinet. 2009;48:543–54.PubMedCrossRef

go back to reference Lucero ML, Gonzalo A, Mumford R, Betanzos M, Alejandro A. An overview of bilastine metabolism during preclinical investigations. Drug Chem Toxicol. 2012;35(Suppl 1):18–24.PubMedCrossRef Lucero ML, Gonzalo A, Mumford R, Betanzos M, Alejandro A. An overview of bilastine metabolism during preclinical investigations. Drug Chem Toxicol. 2012;35(Suppl 1):18–24.PubMedCrossRef

go back to reference Wang XY, Lim-Jurado M, Prepageran N, Tantilipikorn P, de Wang Y. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag. 2016;12:585–97.PubMedPubMedCentralCrossRef Wang XY, Lim-Jurado M, Prepageran N, Tantilipikorn P, de Wang Y. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag. 2016;12:585–97.PubMedPubMedCentralCrossRef

go back to reference Antonijoan R, Coimbra J, García-Gea C, Puntes M, Gich I, Campo C, Valiente R, Labeaga L. Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. Curr Med Res Opin. 2017;33:129–36.PubMedCrossRef Antonijoan R, Coimbra J, García-Gea C, Puntes M, Gich I, Campo C, Valiente R, Labeaga L. Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers. Curr Med Res Opin. 2017;33:129–36.PubMedCrossRef

go back to reference Lasseter KC, Sologuren A, La Noce A, Dilzer SC. Evaluation of the single-dose pharmacokinetics of bilastine in subjects with various degrees of renal insufficiency. Clin Drug Investig. 2013;33:665–73.PubMedPubMedCentralCrossRef Lasseter KC, Sologuren A, La Noce A, Dilzer SC. Evaluation of the single-dose pharmacokinetics of bilastine in subjects with various degrees of renal insufficiency. Clin Drug Investig. 2013;33:665–73.PubMedPubMedCentralCrossRef

go back to reference Sologuren A, Viñas R, Cordón E, Riesgo SE, Del Mar Forés M, Senán MR, Fernández S, Labeaga L, Ruiz-Miján M. Open-label safety assessment of bilastine in elderly patients with allergic rhinoconjunctivitis and/or urticaria. Allergy Asthma Proc. 2018;39:299–304.PubMedCrossRef Sologuren A, Viñas R, Cordón E, Riesgo SE, Del Mar Forés M, Senán MR, Fernández S, Labeaga L, Ruiz-Miján M. Open-label safety assessment of bilastine in elderly patients with allergic rhinoconjunctivitis and/or urticaria. Allergy Asthma Proc. 2018;39:299–304.PubMedCrossRef

go back to reference Kawauchi H, Yanai K, Wang DY, Itahashi K, Okubo K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci. 2019;20:E213.PubMedCrossRef Kawauchi H, Yanai K, Wang DY, Itahashi K, Okubo K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci. 2019;20:E213.PubMedCrossRef

go back to reference Farre M, Perez-Mana C, Papaseit E, Menoyo E, Pérez M, Martin S, Bullich S, Rojas S, Herance JR, Trampal C, Labeaga L, Valiente R. Bilastine vs. hydroxyzine: occupation of brain histamine H1-receptors evaluated by positron emission tomography in healthy volunteers. Br J Clin Pharmacol. 2014;78:970–80.PubMedPubMedCentralCrossRef Farre M, Perez-Mana C, Papaseit E, Menoyo E, Pérez M, Martin S, Bullich S, Rojas S, Herance JR, Trampal C, Labeaga L, Valiente R. Bilastine vs. hydroxyzine: occupation of brain histamine H1-receptors evaluated by positron emission tomography in healthy volunteers. Br J Clin Pharmacol. 2014;78:970–80.PubMedPubMedCentralCrossRef

go back to reference Zuberbier T, Oanta A, Bogacka E, Medina I, Wesel F, Uhl P, Antépara I, Jáuregui I, Valiente R, Bilastine International Working Group. Bilastine International Work-ing Group. Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study. Allergy. 2010;65:516–28.PubMedCrossRef Zuberbier T, Oanta A, Bogacka E, Medina I, Wesel F, Uhl P, Antépara I, Jáuregui I, Valiente R, Bilastine International Working Group. Bilastine International Work-ing Group. Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study. Allergy. 2010;65:516–28.PubMedCrossRef

go back to reference Hide M, Yagami A, Togawa M, Saito A, Furue M. Efficacy and safety of bilastine in Japanese patients with chronic spontaneous urticaria: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II/III study. Allergol Int. 2017;66:317–25.PubMedCrossRef Hide M, Yagami A, Togawa M, Saito A, Furue M. Efficacy and safety of bilastine in Japanese patients with chronic spontaneous urticaria: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II/III study. Allergol Int. 2017;66:317–25.PubMedCrossRef

go back to reference Yagami A, Furue M, Togawa M, Saito A, Hide M. One-year safety and efficacy study of bilastine treatment in Japanese patients with chronic spontaneous urticaria or pruritus associated with skin diseases. J Dermatol. 2017;44:375–85.PubMedCrossRef Yagami A, Furue M, Togawa M, Saito A, Hide M. One-year safety and efficacy study of bilastine treatment in Japanese patients with chronic spontaneous urticaria or pruritus associated with skin diseases. J Dermatol. 2017;44:375–85.PubMedCrossRef

go back to reference Conen S, Theunissen EL, Van Oers AC, Valiente R, Ramaekers JG. Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers. J Psychopharmacol. 2011;25:1517–23.PubMedCrossRef Conen S, Theunissen EL, Van Oers AC, Valiente R, Ramaekers JG. Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers. J Psychopharmacol. 2011;25:1517–23.PubMedCrossRef

go back to reference Demonte A, Guanti MB, Liberati S, Biffi A, Fernando F, Fainello M, Pepe P. Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients. Eur Rev Med Pharmacol Sci. 2018;22:820–8.PubMed Demonte A, Guanti MB, Liberati S, Biffi A, Fernando F, Fainello M, Pepe P. Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients. Eur Rev Med Pharmacol Sci. 2018;22:820–8.PubMed

go back to reference Reményi A, Grósz A, Szabó SA, Tótka Z, Molnár D, Helfferich F. Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study. Expert Opin Drug Saf. 2018;17:859–68.PubMedCrossRef Reményi A, Grósz A, Szabó SA, Tótka Z, Molnár D, Helfferich F. Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study. Expert Opin Drug Saf. 2018;17:859–68.PubMedCrossRef

go back to reference Tyl B, Kabbaj M, Azzam S, Sologuren A, Valiente R, Reinbolt E, Roupe K, Blanco N, Wheeler W. Lack of significant effect of bilastine administered at therapeutic and supratherapeutic doses and concomitantly with ketoconazole on ventricular repolarization: results of a thorough QT study (TQTS) with QT-concentration analysis. J Clin Pharmacol. 2012;52:893–903.PubMedCrossRef Tyl B, Kabbaj M, Azzam S, Sologuren A, Valiente R, Reinbolt E, Roupe K, Blanco N, Wheeler W. Lack of significant effect of bilastine administered at therapeutic and supratherapeutic doses and concomitantly with ketoconazole on ventricular repolarization: results of a thorough QT study (TQTS) with QT-concentration analysis. J Clin Pharmacol. 2012;52:893–903.PubMedCrossRef

go back to reference Novak Z, Yanez A, Kiss I, Kuna P, Tortajada-Girbés M, Valiente R, Bilastine Paediatric Safety Study Group. Safety and tolerability of bilastine 10 mg administered for 12 weeks in children with allergic diseases. Pediatr Allergy Immunol. 2016;27:493–8.PubMedCrossRef Novak Z, Yanez A, Kiss I, Kuna P, Tortajada-Girbés M, Valiente R, Bilastine Paediatric Safety Study Group. Safety and tolerability of bilastine 10 mg administered for 12 weeks in children with allergic diseases. Pediatr Allergy Immunol. 2016;27:493–8.PubMedCrossRef

go back to reference Baltes E, Coupez R, Giezek H, Voss G, Meyerhoff C, Strolin Benedetti M. Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam Clin Pharmacol. 2001;15:269–77.PubMedCrossRef Baltes E, Coupez R, Giezek H, Voss G, Meyerhoff C, Strolin Benedetti M. Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Fundam Clin Pharmacol. 2001;15:269–77.PubMedCrossRef

go back to reference Pampura A, Papadopoulos NG, Špičák V, Kurzawa R. Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. Int Arch Allergy Immunol. 2011;155:367–78.PubMedCrossRef Pampura A, Papadopoulos NG, Špičák V, Kurzawa R. Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease. Int Arch Allergy Immunol. 2011;155:367–78.PubMedCrossRef

go back to reference Berger WE. The safety and efficacy of desloratadine for the management of allergic disease. Drug Saf. 2005;28:1101–18.PubMedCrossRef Berger WE. The safety and efficacy of desloratadine for the management of allergic disease. Drug Saf. 2005;28:1101–18.PubMedCrossRef

go back to reference Krishna R, Krishnaswamiy S, Kittner B, Sankoh A, Jensen B. The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride. Biopharm Drug Dispos. 2004;25:373–87.PubMedCrossRef Krishna R, Krishnaswamiy S, Kittner B, Sankoh A, Jensen B. The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride. Biopharm Drug Dispos. 2004;25:373–87.PubMedCrossRef

go back to reference Salmun L, Herron J, Banfield C, Padhi D, Lorber R, Affrime M. The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years. Clin Ther. 2000;22:613–21.PubMedCrossRef Salmun L, Herron J, Banfield C, Padhi D, Lorber R, Affrime M. The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years. Clin Ther. 2000;22:613–21.PubMedCrossRef

go back to reference Potter P, Mitha E, Barkai L, Mezei G, Santamaria E, Izquierdo I, Maurer M. Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2–11 years. Pediatr Allergy Immunol. 2016;27:55–61.PubMedCrossRef Potter P, Mitha E, Barkai L, Mezei G, Santamaria E, Izquierdo I, Maurer M. Rupatadine is effective in the treatment of chronic spontaneous urticaria in children aged 2–11 years. Pediatr Allergy Immunol. 2016;27:55–61.PubMedCrossRef

go back to reference Vozmediano V, Sologuren A, Lukas JC, Leal N, Rodriguez M. Model informed pediatric development applied to bilastine: ontogenic pk model development, dose selection for first time in children and pk study design. Pharm Res. 2017;34:2720–34.PubMedCrossRef Vozmediano V, Sologuren A, Lukas JC, Leal N, Rodriguez M. Model informed pediatric development applied to bilastine: ontogenic pk model development, dose selection for first time in children and pk study design. Pharm Res. 2017;34:2720–34.PubMedCrossRef

go back to reference Vozmediano V, Lukas JC, Encinas E, Schmidt S, Sologuren A, Valiente R, Labeaga L, Campo C, Rodriguez M. Model-informed pediatric development applied to bilastine: analysis of the clinical PK data and confirmation of the dose selected for the target population. Eur J Pharm Sci. 2019;128:180–92.PubMedCrossRef Vozmediano V, Lukas JC, Encinas E, Schmidt S, Sologuren A, Valiente R, Labeaga L, Campo C, Rodriguez M. Model-informed pediatric development applied to bilastine: analysis of the clinical PK data and confirmation of the dose selected for the target population. Eur J Pharm Sci. 2019;128:180–92.PubMedCrossRef

go back to reference Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, Mayes SD, Tsaoussoglou M, Rodriguez-Muñoz A, Bixler EO. Learning, attention/hyperactivity, and conduct problems as sequelae of excessive daytime sleepiness in a general population study of young children. Sleep. 2012;35:627–32.PubMedPubMedCentral Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, Mayes SD, Tsaoussoglou M, Rodriguez-Muñoz A, Bixler EO. Learning, attention/hyperactivity, and conduct problems as sequelae of excessive daytime sleepiness in a general population study of young children. Sleep. 2012;35:627–32.PubMedPubMedCentral

go back to reference Vuurman EF, van Veggel LM, Uiterwijk MM, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy. 1993;71:121–6.PubMed Vuurman EF, van Veggel LM, Uiterwijk MM, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy. 1993;71:121–6.PubMed

go back to reference Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M. The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther. 2017;178:148–56.PubMedCrossRef Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, Tashiro M. The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther. 2017;178:148–56.PubMedCrossRef

go back to reference Marcus CL. Daytime sleepiness in children: when a quiet child is not necessarily a good thing. Paediatr Respir Rev. 2018;25:1–2.PubMed Marcus CL. Daytime sleepiness in children: when a quiet child is not necessarily a good thing. Paediatr Respir Rev. 2018;25:1–2.PubMed

go back to reference Cerasuolo M, Giganti F, Conte F, Costanzo LM, Della Monica C, Arzilli C, Marchesano R, Perrella A, Ficca G. Schooltime subjective sleepiness and performance in Italian primary school children. Chronobiol Int. 2016;33:883–92.PubMedCrossRef Cerasuolo M, Giganti F, Conte F, Costanzo LM, Della Monica C, Arzilli C, Marchesano R, Perrella A, Ficca G. Schooltime subjective sleepiness and performance in Italian primary school children. Chronobiol Int. 2016;33:883–92.PubMedCrossRef

go back to reference Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bogels SM. The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev. 2010;14:179–89.PubMedCrossRef Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bogels SM. The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev. 2010;14:179–89.PubMedCrossRef

go back to reference Coimbra J, Campo C, Labeaga L, Puntes M, Gich I, Martínez J, Antonijoan R. Lack of clinical relevance of bilastine-food pharmacokinetic interaction assessed by inhibition of histamine-induced wheal and flare response in healthy volunteers. Skin Allergy Meeting 2019. Munich (Germany) April 4–6, 2019. Abstracts Online. Coimbra J, Campo C, Labeaga L, Puntes M, Gich I, Martínez J, Antonijoan R. Lack of clinical relevance of bilastine-food pharmacokinetic interaction assessed by inhibition of histamine-induced wheal and flare response in healthy volunteers. Skin Allergy Meeting 2019. Munich (Germany) April 4–6, 2019. Abstracts Online.