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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2016

Open Access 01-12-2016 | Brief communication

Triclosan promotes epicutaneous sensitization to peanut in mice

Authors: Steven Tobar, Leticia Tordesillas, M. Cecilia Berin

Published in: Clinical and Translational Allergy | Issue 1/2016

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Abstract

Background

Peanut allergy is increasing in prevalence due to unknown factors. A growing body of clinical evidence suggests sensitization to peanut occurs through the skin, supported by findings in mouse models. There is a need to identify environmental factors that promote epicutaneous sensitization to peanut. Triclosan is an antimicrobial found in household products that has been associated with food sensitization in humans. We tested the impact of triclosan on epicutaneous sensitization to peanut, as well as the milk allergen α-lactalbumin (ALA).

Results

We observed that topical triclosan promoted epicutaneous sensitization to both peanut and ALA, and promoted anaphylaxis to peanut.

Conclusions

Our results demonstrate that the mouse model of epicutaneous sensitization to foods is effective for demonstrating the clinically significant impact of environmental factors such as triclosan on food allergy.
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Metadata
Title
Triclosan promotes epicutaneous sensitization to peanut in mice
Authors
Steven Tobar
Leticia Tordesillas
M. Cecilia Berin
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2016
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/s13601-016-0102-2

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