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Biology of Mood & Anxiety Disorders
Published in: Biology of Mood & Anxiety Disorders 1/2014

Open Access 01-12-2014 | Research

Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders

Authors: Lisa L Hamm, Rachel H Jacobs, Meghan W Johnson, Daniel A Fitzgerald, Kate D Fitzgerald, Scott A Langenecker, Christopher S Monk, K Luan Phan

Published in: Biology of Mood & Anxiety Disorders | Issue 1/2014

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Abstract

Background

Childhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctional connectivity in amygdala-based circuits at rest in adolescents, consistent with adults. However, neural mechanisms underlying a broad spectrum of often-comorbid anxiety disorders in children remains unclear and understudied. The current study examines amygdala functional connectivity at rest in children and adolescents across comorbid anxiety disorders (ADs) including youth with primary diagnoses of GAD and social phobia (SP).

Results

Compared with healthy controls (HCs), AD youth exhibited hyperconnectivity between the right amygdala and the insula and hypoconnectivity between the left amygdala and the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Within the AD group, connectivity was not correlated with anxiety severity and only the amygdala-PCC connectivity was positively correlated with age.

Conclusions

Our findings indicate that youth with comorbid ADs demonstrate aberrant connectivity in the anterior limbic network (ALN) as well as the PCC at rest. This extends upon previous work suggesting alterations in amygdala circuits underlying fear learning, emotion regulation, and the processing of interoceptive states. Presence of these findings within this young, comorbid sample points to underlying common mechanisms across ADs and illuminates future targets for prevention and intervention in childhood.
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Metadata
Title
Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders
Authors
Lisa L Hamm
Rachel H Jacobs
Meghan W Johnson
Daniel A Fitzgerald
Kate D Fitzgerald
Scott A Langenecker
Christopher S Monk
K Luan Phan
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Biology of Mood & Anxiety Disorders / Issue 1/2014
Electronic ISSN: 2045-5380
DOI
https://doi.org/10.1186/s13587-014-0015-4

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